RR-9: CLARITY-BPA Core Study: A Perinatal and Chronic Extended-Dose-Range Study of Bisphenol A in Rats
Publications
A two-year toxicology study of bisphenol A (BPA) in Sprague-Dawley rats: CLARITY-BPA core study results. Camacho L, Lewis SM, Vanlandingham MM, Olson GR, Davis KJ, Patton RE, Twaddle NC, Doerge DR, Churchwell MI, Bryant MS, McLellen FM, Woodling K, Felton RP, Maisha MP, Juliar BE, Gamboa da Costa G, Delclos KB. Food Chem Toxicol. 2019 Jul 28:110728. doi: 10.1016/j.fct.2019.110728. PMID: 31365888
Supplemental Appendices
- 7-Appendix VII Chemistry Report (10 MB)
- 8-Appendix VIII Microbiology Report (6 MB)
- 9-Appendix IX Diet Preparation Services Report (649 KB)
- 12-Appendix XII Diet Nutrient and Contaminant Analyses (1 MB)
- 13a-Appendix XIIIa Interim Sacrifice Feed Consumption Statistical Report (337 KB)
- 13b-Appendix XIIIb Terminal Sacrifice Feed Consumption Statistical Report (416 KB)
- 14-Appendix XIV Background BPA Ingestion (291 KB)
- 17-Appendix XVII Gestational Weight Statistical Report (304 KB)
- 18-Appendix XVIII AVIS Statistical Report (186 KB)
- 19-Appendix XIX Litter Parameters Statistical Report (541 KB)
- 20-Appendix XX Preweaning Survival Statistical Report (601 KB)
- 21-Appendix XXI Survival Interim Sacrifice Statistical Report (789 KB)
- 22-Appendix XXII Survival Terminal Sacrifice Statistical Report (921 KB)
- 23-Appendix XXIII Preweaning Body Weight Statistical Report (864 KB)
- 24-Appendix XXIV Body Weight Interim Sacrifice Statistical Report (971 KB)
- 25-Appendix XXV Body Weight Terminal Sacrifice Statistical Report (2 MB)
- 26-Appendix XXVI Developmental Measures Statistical Report (257 KB)
- 27-Appendix XXVII Vaginal Cytology Statistical Report (847 KB)
- 28-Appendix XXVIII Time to Aberrant Cycling Statistical Report (568 KB)
- 29-Appendix XXIX Interim Sacrifice Clinical Chemistry Statistical Report Amended (1 MB)
- 30-Appendix XXX Organ Weight Statistical Report (2 MB)
- 31-Appendix XXXI Sperm Parameters Statistical Report (413 KB)
- 32-Appendix XXXII 2190-03 Final Pathology Report - 1 Year and 2 Year AMENDED (7 MB)
- 33-Appendix XXXIII Interim Sacrifice Lesion Incidence Statistical Report (2 MB)
- 33-Appendix XXXIII Interim Sacrifice Lesion Incidence Statistical Report Addendum (166 KB)
- 34-Appendix XXXIV Terminal Sacrifice Lesion Incidence Statistical Report (3 MB)
- 34-Appendix XXXIV Terminal Sacrifice Lesion Incidence Statistical Report Addendum (157 KB)
- List of Appendices (20 KB)
Animal Sets
- Dam Animal Set Information (58 KB)
- Interim Animal Set Information (71 KB)
- Prewean Animal Set Information (268 KB)
- Terminal Animal Set Information (129 KB)
Individual Animal Data
Dam and Preweaning Pup Data
- Individual Animal Dam and Prewean Pups Clinical Observations Data (963 KB)
- Individual Animal Dam Body Weight Data (129 KB)
- Individual Animal Dam Gestational Body Weight Data (320 KB)
- Individual Animal Dam Uterine Implantation Sites Data (28 KB)
- Individual Animal Litter Parameters Data (52 KB)
- Individual Animal Prewean Body Weight PND 1 4 7 14 21 Data (712 KB)
- Individual Animal Preweaning Animals Body Weight Data (784 KB)
- Individual Animal Prewean Survival Data (165 KB)
1-Year Study Data
- Individual Animal Interim Animals All Body Weight Data (1 MB)
- Individual Animal Interim Body Weight Data (364 KB)
- Individual Animal Interim Clinical Chemistry Data (507 KB)
- Individual Animal Interim Clinical Observations Data for Cages 1-388 (496 KB)
- Individual Animal Interim Clinical Observations Data for Cages 389-770 (488 KB)
- Individual Animal Interim Clinical Observations Data for Cages 771-1012 (193 KB)
- Individual Animal Interim Food Consumption Data (167 KB)
- Individual Animal Interim Gross Observations Data (533 KB)
- Individual Animal Interim Hematology Data (548 KB)
- Individual Animal Interim Histopathology Data (623 KB)
- Individual Animal Interim Organ Weight Data (435 KB)
- Individual Animal Interim Sperm Count Data (37 KB)
- Individual Animal Interim SurvivaI Data (40 KB)
- Individual Animal Interim Troponin Data (52 KB)
2-Year Study Data
- Individual Animal Terminal Aberrant Cycling Data (608 KB)
- Individual Animal Terminal Animals All Body Weight Data (4 MB)
- Individual Animal Terminal Body Weight Data (1 MB)
- Individual Animal Terminal Clinical Observations Data for Cages 1-388 (2 MB)
- Individual Animal Terminal Clinical Observations Data for Cages 389-770 (2 MB)
- Individual Animal Terminal Clinical Observations Data for Cages 771-1012 (1 MB)
- Individual Animal Terminal Food Consumption Data (709 KB)
- Individual Animal Terminal Gross Observations Data (1 MB)
- Individual Animal Terminal Histopathology Data (3 MB)
- Individual Animal Terminal Survival Data (72 KB)
- Individual Animal Terminal Vaginal Cytology Data (658 KB)
- Individual Animal Terminal Vaginal Opening Data (29 KB)
Study Tables
Dam and Preweaning Pup Study Tables
- Data from 17-Appendix XVII Gestational Weight Statistical Report (961 KB)
- Data from 18-Appendix XVIII AVIS Statistical Report (52 KB)
- Data from 19-Appendix XIX Litter Parameters Statistical Report (342 KB)
- Data from 20-Appendix XX Preweaning Survival Statistical Report (122 KB)
- Data from 23-Appendix XXIII Preweaning Body Weight Statistical Report (294 KB)
1-Year Study Tables
- Data from 13a-Appendix XIIIa Interim Sacrifice Feed Consumption Statistical Report (683 KB)
- Data from 14-Appendix XIV Background BPA Ingestion-1 Year (446 KB)
- Data from 14-Appendix XIV Background BPA Ingestion Averages (128 KB)
- Data from 21-Appendix XXI Survival Interim Sacrifice Statistical Report (204 KB)
- Data from 24 Appendix XXIV Body Weight Interim Sacrifice Statistical Report (362 KB)
- Data from 24 Appendix XXIV Body Weight Interim Sacrifice Statistical Report - Outliers (674 KB)
- Data from 29-Appendix XXIX Interim Sacrifice Clinical Chemistry Statistical Report Amended (1 MB)
- Data from 30-Appendix XXX Organ Weight Statistical Report (8 MB)
- Data from 31-Appendix XXXI Sperm Parameters Statistical Report (1 MB)
- Data from 32-Appendix XXXII - P02 - Incidence Rates of Neoplasms by Anatomic Site - 1 Year (148 KB)
- Data from 32-Appendix XXXII - P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site - 1 Year (201 KB)
- Data from 32-Appendix XXXII - P04 - Neoplasms by Individual Animal - 1 Year (850 KB)
- Data from 32-Appendix XXXII - P05 - Incidence Rates of Neoplasms by Anatomic Site (Systemic Lesions Abridged) - 1 Year (141 KB)
- Data from 32-Appendix XXXII - P09 - Non-Neoplastic Lesions by Individual Animal- 1 Year (1 MB)
- Data from 32-Appendix XXXII - P22 - Cause Of Death Summary - 1 Year (65 KB)
- Data from 33-Appendix XXXIII Interim Sacrifice Lesion Incidence Statistical Report - Neoplastic (205 KB)
- Data from 33-Appendix XXXIII Interim Sacrifice Lesion Incidence Statistical Report - Non-Neoplastic (2 MB)
- Data from 33-Appendix XXXIII Interim Sacrifice Lesion Incidence Statistical Report Addendum (77 KB)
2-Year Study Tables
- Data from 13b-Appendix XIIIb Terminal Sacrifice Feed Consumption Statistical Report (803 KB)
- Data from 14-Appendix XIV Background BPA Ingestion-2 Year (848 KB)
- Data from 14-Appendix XIV Background BPA Ingestion Averages (128 KB)
- Data from 22-Appendix XXII Survival Terminal Sacrifice Statistical Report (205 KB)
- Data from 25-Appendix XXV Body Weight Terminal Sacrifice Statistical Report (547 KB)
- Data from 25-Appendix XXV Body Weight Terminal Sacrifice Statistical Report - Outliers (662 KB)
- Data from 26-Appendix XXVI Developmental Measures Statistical Report (198 KB)
- Data from 27-Appendix XXVII Vaginal Cytology Statistical Report (1 MB)
- Data from 28-Appendix XXVIII Time to Aberrant Cycling Statistical Report (140 KB)
- Data from 32-Appendix XXXII - P02 - Incidence Rates of Neoplasms by Anatomic Site - 2 Year (265 KB)
- Data from 32-Appendix XXXII - P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site - 2 Year (351 KB)
- Data from 32-Appendix XXXII - P04 - Neoplasms by Individual Animal - 2 Year (2 MB)
- Data from 32-Appendix XXXII - P05 - Incidence Rates of Neoplasms by Anatomic Site (Systemic Lesions Abridged) - 2 Year (213 KB)
- Data from 32-Appendix XXXII - P09 - Non-Neoplastic Lesions by Individual Animal - 2 Year (4 MB)
- Data from 32-Appendix XXXII - P22 - Cause Of Death Summary - 2 Year (100 KB)
- Data from 34-Appendix XXXIV Terminal Sacrifice Lesion Incidence Statistical Report - Neoplastic (382 KB)
- Data from 34-Appendix XXXIV Terminal Sacrifice Lesion Incidence Statistical Report - Non-Neoplastic (3 MB)
- Data from 34-Appendix XXXIV Terminal Sacrifice Lesion Incidence Statistical Report Addendum (688 KB)