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Study Information
Study Attribute Value
CEBS Accession Number: 002-01364-0007-0000-3
Chemical Name: 2-Naphthylamine
CASRN: 91-59-8
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 080086_SCE
Study Result: Positive


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 03/21/85 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Dimethyl Sulfoxide 
 0         
 4 5.00 ± 0.432
Test Chemical 2-Naphthylamine 
87.5       
 4 6.76 ± 0.617
  
175         
 4 7.00 ± 0.233
  
350         
 4 10.97 ± 1.146
Positive Control Dimethylbenzanthracene 
2.5       
 4 13.66 ± 1.732


Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 12/02/87 42 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  42 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Dimethyl Sulfoxide 
 0         
 4 5.67 ± 0.264
Test Chemical 2-Naphthylamine 
87.5       
 4 5.49 ± 0.573
  
175         
 4 7.34 ± 1.072
  
350         
 7 8.27 ± 0.762
Positive Control Dimethylbenzanthracene 
2.5       
 4 12.70 ± 1.181


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed