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Study Information
Study Attribute Value
CEBS Accession Number: 002-01364-0008-0000-4
Chemical Name: 2-Naphthylamine
CASRN: 91-59-8
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 080086_CA
Study Result: Equivocal

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 03/07/85 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.9789
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 5.25 ± 1.25 0.0007
Test Chemical 2-Naphthylamine 
87.5       
 8 1.00 ± 0.76 0.6313
  
175         
 8 0.75 ± 0.37 0.7614
  
350         
 7 0.00 ± 0.00 0.9821
Vehicle Control No Stressor 
 0         
 8 1.25 ± 0.75 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 01/12/88 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.0177
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 34.75 ± 1.92 0.0000
Test Chemical 2-Naphthylamine 
87.5       
 8 0.75 ± 0.37 0.6479
  
175         
 8 1.25 ± 0.75 0.3687
  
350         
 8 2.50 ± 0.98 0.0529
Vehicle Control No Stressor 
 0         
 8 1.00 ± 0.53 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 05/10/88 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.0643
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
50         
 8 20.50 ± 3.38 0.0000
Test Chemical 2-Naphthylamine 
350         
 8 3.50 ± 0.63 0.0177
  
437.5       
 8 2.25 ± 0.45 0.1232
Vehicle Control No Stressor 
 0         
 7 1.14 ± 0.59 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed