Genetic Toxicology - Rodent Cytogenetics

Government Funding Lapse

Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit  cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

Study Information
Study Attribute	Value
CEBS Accession Number:	002-01519-0006-0000-4
Chemical Name:	4-Nitroquinoline-N-oxide
CASRN:	56-57-5
NTP Study Type:	Genetic Toxicology - Rodent Cytogenetics
NTP Study ID:	314987_CA
Study Result:	Positive

View Study Details | View Protocol | Download To Excel


Test Type	Start Date	Sample Time (h)	Species	Sex	Tissue	Protocol	Trend Test P
CA	01/15/85	17	Mouse	Male	Bone Marrow	Intraperitoneal Injection x 1/study, 17 hour	0.0000

Test Group		Dose (mg/kg)	n	Percent Cells w/ Aberrations (Mean ± SEM)	Pairwise P
Positive Control	Dimethylbenzanthracene	100	8	24.75 ± 3.23	0.0000
Test Chemical	4-Nitroquinoline-N-oxide	15	8	4.00 ± 1.46	0.5706
		30	8	12.00 ± 2.62	0.0000
		60	8	37.25 ± 5.53	0.0000
Vehicle Control	No Stressor	0	8	4.25 ± 0.80	0.0000


Test Type	Start Date	Sample Time (h)	Species	Sex	Tissue	Protocol	Trend Test P
CA	09/05/85	17	Mouse	Male	Bone Marrow	Intraperitoneal Injection x 1/study, 17 hour	0.0000

Test Group		Dose (mg/kg)	n	Percent Cells w/ Aberrations (Mean ± SEM)	Pairwise P
Test Chemical	4-Nitroquinoline-N-oxide	40	8	15.75 ± 2.43	0.0000
Vehicle Control	No Stressor	0	8	1.75 ± 0.59	0.0000

Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed