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Study Information
Study Attribute Value
CEBS Accession Number: 002-01604-0001-0000-4
Chemical Name: Acrylamide
CASRN: 79-06-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 279150_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 01/23/1986    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1047 416 0.397 8.32 26.0 0.000
Test Chemical Acrylamide 
5         
 50 1052 474 0.451 9.48 26.0 13.401 
16         
 50 1047 411 0.393 8.22 26.0 -1.202 
50         
 50 1044 393 0.376 7.86 26.0 -5.257 
160         
 50 1051 557 0.530 11.14 26.0 33.385 
500         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C 
 0.0E-4    
 50 1051 674 0.641 13.48 26.0 61.403
Mitomycin-C 
 0.005     
 10 210 322 1.533 32.20 26.0 285.913
Trend: 2.999        
Probability: 0.001        

Trial #: 2    Activation: No Activation    Date: 03/06/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1047 346 0.330 6.92 26.0 0.000
Test Chemical Acrylamide 
30         
 50 1049 394 0.376 7.88 26.0 13.656 
50         
 50 1048 418 0.399 8.36 26.0 20.694 
100         
 50 1047 449 0.429 8.98 26.0 29.769 
160         
 50 1047 476 0.455 9.52 26.0 37.572 
300         
 0 0 0 0.000 0.00 31.0 N/A
Positive Control Mitomycin-C 
 0.0E-4    
 50 1045 514 0.492 10.28 26.0 48.839
Mitomycin-C 
 0.005     
 10 211 264 1.251 26.40 26.0 278.610
Trend: 4.892        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/15/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1046 441 0.422 8.82 26.0 0.000
Test Chemical Acrylamide 
160         
 50 1053 470 0.446 9.40 26.0 5.867 
500         
 50 1047 512 0.489 10.24 26.0 15.989 
1000         
 50 1047 553 0.528 11.06 26.0 25.277 
1600         
 50 1048 674 0.643 13.48 26.0 52.543
Positive Control Cyclophosphamide 
 0.1       
 50 1049 571 0.544 11.42 26.0 29.108
Cyclophosphamide 
 0.6       
 10 210 251 1.195 25.10 26.0 183.496
Trend: 7.212        
Probability: 0.000