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Study Information
Study Attribute Value
CEBS Accession Number: 002-01633-0015-0000-1
Chemical Name: Allyl isothiocyanate
CASRN: 57-06-7
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 056227_SCE
Study Result: Positive


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 08/02/88 42 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  42 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Dimethyl Sulfoxide 
 0         
 4 4.59 ± 0.405
Test Chemical Allyl isothiocyanate 
12.5       
 4 5.08 ± 0.605
  
25         
 4 5.39 ± 0.504
  
50         
 4 7.39 ± 0.990
Positive Control Dimethylbenzanthracene 
2.5       
 4 13.99 ± 0.802


Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 09/01/88 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Dimethyl Sulfoxide 
 0         
 4 4.56 ± 0.230
Test Chemical Allyl isothiocyanate 
12.5       
 4 5.29 ± 0.347
  
25         
 4 5.63 ± 0.246
  
50         
 4 6.18 ± 0.718
Positive Control Dimethylbenzanthracene 
2.5       
 4 12.79 ± 0.720


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed