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Study Information
Study Attribute Value
CEBS Accession Number: 002-01694-0015-0000-8
Chemical Name: Benzidine dihydrochloride
CASRN: 531-85-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 758694_SCE
Study Result: Positive


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 03/20/85 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 3.37 ± 0.432
Test Chemical Benzidine dihydrochloride 
50         
 4 6.12 ± 0.563
  
100         
 4 6.21 ± 0.522
  
200         
 4 6.73 ± 0.605
Positive Control Dimethylbenzanthracene 
100         
 4 13.27 ± 0.951


Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 02/10/87 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 4.37 ± 0.655
Test Chemical Benzidine dihydrochloride 
50         
 4 7.44 ± 0.995
  
100         
 4 6.90 ± 0.266
  
200         
 4 9.83 ± 1.236
Positive Control Dimethylbenzanthracene 
2.5       
 4 9.84 ± 0.710


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed