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Study Information
Study Attribute Value
CEBS Accession Number: 002-01750-0020-0000-7
Chemical Name: Butyl benzyl phthalate
CASRN: 85-68-7
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 336452_CA
Study Result: Positive

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 08/31/87 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.4238
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 26.75 ± 2.56 0.0000
Test Chemical Butyl benzyl phthalate 
1250         
 8 0.75 ± 0.37 0.1580
  
2500         
 8 0.25 ± 0.25 0.5000
  
5000         
 8 0.50 ± 0.33 0.2815
Vehicle Control No Stressor 
 0         
 8 0.25 ± 0.25 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 12/17/87 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.0029
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 11.50 ± 1.50 0.0000
Test Chemical Butyl benzyl phthalate 
1250         
 8 1.50 ± 0.50 0.1573
  
2500         
 8 0.75 ± 0.53 0.5000
  
5000         
 8 3.25 ± 1.13 0.0058
Vehicle Control No Stressor 
 0         
 8 0.75 ± 0.53 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 08/22/88 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.0033
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 14.00 ± 2.80 0.0000
Test Chemical Butyl benzyl phthalate 
2500         
 8 2.25 ± 0.70 0.0810
  
3750         
 8 2.00 ± 0.65 0.1223
  
5000         
 8 4.25 ± 1.28 0.0020
Vehicle Control No Stressor 
 0         
 8 1.00 ± 0.53 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed