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Study Information
Study Attribute Value
CEBS Accession Number: 002-01902-0001-0000-5
Chemical Name: Colchicine
CASRN: 64-86-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 103168_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 09/16/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 474 0.452 9.48 26.0 0.000
Test Chemical Colchicine 
 0.005     
 50 1049 459 0.438 9.18 26.0 -3.165 
 0.016     
 50 1051 421 0.401 8.42 26.0 -11.350 
 0.05      
 50 1047 446 0.426 8.92 26.0 -5.727 
 0.16      
 17 352 156 0.443 9.18 26.0 -1.920
Positive Control Mitomycin-C 
 0.005     
 25 525 616 1.173 24.64 26.0 159.668
Trend: -0.873        
Probability: 0.809        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 09/16/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 393 0.375 7.86 26.0 0.000
Test Chemical Colchicine 
 0.1       
 50 1049 355 0.338 7.10 26.0 -9.669 
 0.3       
 50 1048 412 0.393 8.24 26.0 4.935 
 0.4       
 50 1049 424 0.404 8.48 26.0 7.888 
 0.5       
 50 1051 436 0.415 8.72 26.0 10.730 
1.6       
 50 1050 412 0.392 8.24 26.0 4.735
Positive Control Cyclophosphamide 
1         
 50 1049 981 0.935 19.62 26.0 149.618
Trend: 1.963        
Probability: 0.025