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Study Information
Study Attribute Value
CEBS Accession Number: 002-01940-0010-0000-7
Chemical Name: D & C red no. 9
CASRN: 5160-02-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 832755_SCE
Study Result: Positive


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 05/10/88 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 4.99 ± 0.394
Test Chemical D & C red no. 9 
1250         
 4 4.58 ± 0.283
  
2500         
 4 4.27 ± 0.176
  
5000         
 4 4.51 ± 0.193
Positive Control Dimethylbenzanthracene 
2.5       
 4 7.03 ± 0.335


Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 09/07/88 42 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  42 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 5.36 ± 0.148
Test Chemical D & C red no. 9 
1250         
 4 7.12 ± 0.986
  
2500         
 4 7.23 ± 0.174
  
5000         
 4 8.82 ± 0.339
Positive Control Dimethylbenzanthracene 
2.5       
 4 15.06 ± 1.834


Summary of Sister Chromatid Exchange Data (Trial 3)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 12/20/88 42 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  42 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 5.92 ± 0.203
Test Chemical D & C red no. 9 
5000         
 4 8.27 ± 0.178
Positive Control Dimethylbenzanthracene 
25         
 4 19.18 ± 0.690


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed