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Study Information
Study Attribute Value
CEBS Accession Number: 002-02170-0012-0000-5
Chemical Name: Eugenol
CASRN: 97-53-0
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 635999_SCE
Study Result: Positive (Nonstandard Protocol)


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 10/17/88 42 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  42 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 4.78 ± 0.418
Test Chemical Eugenol 
150         
 4 4.38 ± 0.219
  
300         
 4 4.30 ± 0.067
  
600         
 4 5.91 ± 0.549
Positive Control Dimethylbenzanthracene 
2.5       
 4 12.37 ± 0.210


Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 03/14/89 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 5.49 ± 0.365
Test Chemical Eugenol 
150         
 4 5.52 ± 0.395
  
300         
 4 7.44 ± 1.099
  
600         
 4 6.69 ± 1.028
Positive Control Dimethylbenzanthracene 
2.5       
 4 12.81 ± 1.140


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed