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Study Information
Study Attribute Value
CEBS Accession Number: 002-02171-0012-0000-6
Chemical Name: FD & C yellow no. 6
CASRN: 2783-94-0
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 848256_CA
Study Result: Negative

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 10/06/87 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.9659
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Mitomycin-C 
1         
 8 15.25 ± 2.67 0.0000
Test Chemical FD & C yellow no. 6 
1225         
 8 2.25 ± 0.80 0.8549
  
2450         
 8 1.75 ± 0.45 0.9392
  
4900         
 8 1.50 ± 0.63 0.9650
Vehicle Control No Stressor 
 0         
 8 3.50 ± 0.82 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 09/24/91 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.2256
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Mitomycin-C 
1         
 7 19.71 ± 2.16 0.0000
Test Chemical FD & C yellow no. 6 
1225         
 8 2.00 ± 0.85 0.1753
  
2450         
 8 3.00 ± 1.31 0.0395
  
4900         
 8 2.00 ± 0.76 0.1753
Vehicle Control No Stressor 
 0         
 7 1.14 ± 0.40 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed