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Study Information
Study Attribute Value
CEBS Accession Number: 002-02230-0010-0000-0
Chemical Name: HC blue 2
CASRN: 33229-34-4
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 908121_SCE
Study Result: Positive


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 01/28/86 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Dimethyl Sulfoxide 
 0         
 4 3.98 ± 0.136
Test Chemical HC blue 2 
375         
 4 6.03 ± 0.254
  
750         
 4 5.46 ± 0.245
  
1500         
 4 10.00 ± 0.400
Positive Control Dimethylbenzanthracene 
2.5       
 4 12.15 ± 1.491


Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 11/12/86 42 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  42 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Dimethyl Sulfoxide 
 0         
 4 3.76 ± 0.164
Test Chemical HC blue 2 
1125         
 4 5.45 ± 0.396
  
1500         
 4 4.94 ± 0.339
  
1875         
 3 4.84 ± 0.676


Summary of Sister Chromatid Exchange Data (Trial 3)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 12/17/86 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Dimethyl Sulfoxide 
 0         
 4 3.85 ± 0.092
Test Chemical HC blue 2 
1500         
 4 6.72 ± 0.983
Positive Control Dimethylbenzanthracene 
2.5       
 4 9.53 ± 0.786


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed