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Study Information
Study Attribute Value
CEBS Accession Number: 002-02237-0004-0000-0
Chemical Name: Heptachlor
CASRN: 76-44-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 616642_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 

Trial #:1   Activation: No Activation    Date: 08/30/1983    Harvest Time: 24 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0 2 0.020 2.0
Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Heptachlor 
25         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
30         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 
35         
 100 2 0.020 2.0 0 0.000 0.0 1 0.010 1.0 1 0.010 1.0 
40         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.04      
 50 23 0.460 36.0 12 0.240 24.0 10 0.200 16.0 1 0.020 2.0
Trend: -0.003 -0.593 -0.286  
Probability: 0.501 0.723 0.613  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 08/25/1983    Harvest Time: 22 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 2.0 1 0.010 1.0 2 0.020 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 5 0.050 4.0 2 0.020 2.0 1 0.010 1.0 2 0.020 1.0
Test Chemical: Heptachlor 
25         
 100 18 0.180 11.0 14 0.140 11.0 4 0.040 3.0 0 0.000 0.0 
30         
 100 16 0.160 14.0 12 0.120 11.0 4 0.040 4.0 0 0.000 0.0 
35         
 100 16 0.160 14.0 6 0.060 5.0 8 0.080 7.0 2 0.020 2.0 
40         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
12.5       
 25 40 1.600 72.0 29 1.160 60.0 11 0.440 32.0 0 0.000 0.0
Trend: 2.382 0.777 2.223  
Probability: 0.009 0.219 0.013