COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-02310-0014-0000-3
Chemical Name: Isobutyraldehyde
CASRN: 78-84-2
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: A27944_CA
Study Result: Positive

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 02/08/94 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.0000
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 4.75 ± 1.25 0.0272
  
200         
 8 6.50 ± 1.80 0.0016
Test Chemical Isobutyraldehyde 
500         
 8 1.75 ± 1.22 0.6932
  
1000         
 8 2.25 ± 0.80 0.5000
  
1500         
 8 11.14 ± 2.30 0.0000
  
2000         
 0 0.00 ± 0.00 0.0000
Vehicle Control No Stressor 
 0         
 8 2.25 ± 0.96 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 05/24/94 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.0000
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 3.25 ± 1.31 0.0520
  
200         
 8 7.00 ± 2.33 0.0001
Test Chemical Isobutyraldehyde 
1000         
 8 1.50 ± 0.73 0.5000
  
1200         
 8 2.25 ± 0.80 0.2171
  
1500         
 7 3.67 ± 0.88 0.0383
  
1750         
 7 8.86 ± 2.50 0.0000
Vehicle Control No Stressor 
 0         
 8 1.50 ± 0.50 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed