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Study Information
Study Attribute Value
CEBS Accession Number: 002-02366-0002-0000-1
Chemical Name: Lindane
CASRN: 58-89-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 931320_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 05/04/1983    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 5 0.050 5.0 1 0.010 1.0 4 0.040 4.0 0 0.000 0.0
Test Chemical: Lindane 
5         
 100 5 0.050 5.0 0 0.000 0.0 5 0.050 5.0 0 0.000 0.0 
16         
 100 5 0.050 5.0 3 0.030 3.0 2 0.020 2.0 0 0.000 0.0 
50         
 100 8 0.080 8.0 1 0.010 1.0 7 0.070 7.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.15      
 50 32 0.640 40.0 10 0.200 20.0 22 0.440 24.0 0 0.000 0.0
Trend: 0.862 0.610 0.641  
Probability: 0.194 0.271 0.261  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 04/27/1983    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 5 0.050 5.0 1 0.010 1.0 4 0.040 4.0 0 0.000 0.0
Test Chemical: Lindane 
5         
 100 7 0.070 6.0 1 0.010 1.0 6 0.060 5.0 0 0.000 0.0 
16         
 100 8 0.080 8.0 4 0.040 4.0 4 0.040 4.0 0 0.000 0.0 
50         
 100 5 0.050 5.0 0 0.000 0.0 5 0.050 5.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 50 16 0.320 28.0 7 0.140 14.0 9 0.180 18.0 0 0.000 0.0
Trend: 0.192 0.009 0.214  
Probability: 0.424 0.496 0.415