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Study Information
Study Attribute Value
CEBS Accession Number: 002-02395-0030-0000-4
Chemical Name: Melphalan
CASRN: 148-82-3
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 141321_SCE
Study Result: Positive (Nonstandard Protocol)


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 02/07/85 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 5.97 ± 1.083
Test Chemical Melphalan 
 0.25      
 4 12.70 ± 2.340
  
 0.5       
 4 22.55 ± 3.292
  
1         
 4 39.80 ± 8.396
Positive Control Dimethylbenzanthracene 
2.5       
 4 8.83 ± 1.134


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed