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Study Information
Study Attribute Value
CEBS Accession Number: 002-02670-0014-0000-2
Chemical Name: Phenol
CASRN: 108-95-2
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 329606_SCE
Study Result: Positive


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 05/13/86 23 Mouse Male B6C3F1 Bone Marrow Other x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Phosphate Buffered Saline 
 0         
 4 4.14 ± 0.042
Test Chemical Phenol 
75         
 4 5.37 ± 0.084
  
150         
 4 4.73 ± 0.282
  
300         
 3 8.48 ± 0.586
Positive Control Mitomycin-C 
 0.5       
 4 10.70 ± 0.477


Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 08/06/86 17 Mouse Male B6C3F1 Bone Marrow Other x 1,  17 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Phosphate Buffered Saline 
 0         
 4 4.94 ± 0.373
Test Chemical Phenol 
75         
 4 4.04 ± 0.203
  
150         
 4 4.73 ± 0.250
  
300         
 4 5.57 ± 1.203


Summary of Sister Chromatid Exchange Data (Trial 3)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 01/06/87 23 Mouse Male B6C3F1 Bone Marrow Other x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Phosphate Buffered Saline 
 0         
 4 4.32 ± 0.331
Test Chemical Phenol 
225         
 4 6.04 ± 1.055
Positive Control Mitomycin-C 
 0.5       
 4 7.78 ± 0.638


Summary of Sister Chromatid Exchange Data (Trial 4)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 02/12/87 23 Mouse Male B6C3F1 Bone Marrow Other x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Phosphate Buffered Saline 
 0         
 4 4.13 ± 0.273
Test Chemical Phenol 
300         
 4 6.37 ± 0.643
Positive Control Mitomycin-C 
 0.5       
 4 7.11 ± 0.494


Summary of Sister Chromatid Exchange Data (Trial 5)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 10/15/87 23 Mouse Male B6C3F1 Bone Marrow Other x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Phosphate Buffered Saline 
 0         
 4 4.58 ± 0.286
Test Chemical Phenol 
300         
 4 4.20 ± 0.398
Positive Control Mitomycin-C 
 0.5       
 4 8.13 ± 0.790


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed