Government Funding Lapse

Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit  cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Study Information
Study Attribute Value
CEBS Accession Number: 002-02930-0002-0000-8
Chemical Name: Triallyl isocyanurate
CASRN: 1025-15-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 652546_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 05/20/1986    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Triallyl isocyanurate 
146         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
485         
 200 2 0.010 0.5 0 0.000 0.0 2 0.010 0.5 0 0.000 0.0 
1460         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.75      
 400 57 0.143 12.0 35 0.088 8.0 22 0.055 4.8 0 0.000 0.0
Mitomycin-C 
5         
 50 23 0.460 26.0 13 0.260 24.0 10 0.200 14.0 0 0.000 0.0
Trend: 1.274 1.327 0.474  
Probability: 0.101 0.092 0.318  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 05/20/1986    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 10 0.050 4.0 0 0.000 0.0 10 0.050 4.0 0 0.000 0.0
Test Chemical: Triallyl isocyanurate 
291         
 200 4 0.020 2.0 0 0.000 0.0 3 0.015 1.5 1 0.005 1.0 
970         
 200 5 0.025 2.5 1 0.005 0.5 3 0.015 1.5 1 0.005 1.0 
2910         
 200 8 0.040 3.5 1 0.005 0.5 7 0.035 3.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 50 23 0.460 38.0 7 0.140 14.0 14 0.280 22.0 2 0.040 2.0
Trend: -0.193 1.275 -0.623  
Probability: 0.576 0.101 0.733