COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-02934-0017-0000-8
Chemical Name: Tribromomethane
CASRN: 75-25-2
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 244282_SCE
Study Result: Positive


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 07/11/85 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 3.08 ± 0.241
Test Chemical Tribromomethane 
200         
 4 3.05 ± 0.298
  
400         
 4 3.85 ± 0.446
  
800         
 4 3.74 ± 0.503
Positive Control Dimethylbenzanthracene 
2.5       
 4 8.84 ± 0.725


Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 02/05/87 36 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  36 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 4.41 ± 0.242
Test Chemical Tribromomethane 
200         
 4 4.98 ± 0.473
  
400         
 4 6.99 ± 1.443
  
800         
 4 8.27 ± 0.945
Positive Control Dimethylbenzanthracene 
2.5       
 3 11.74 ± 0.535


Summary of Sister Chromatid Exchange Data (Trial 3)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 03/16/87 36 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  36 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 4.55 ± 0.587
Test Chemical Tribromomethane 
800         
 4 6.18 ± 0.620
Positive Control Dimethylbenzanthracene 
2.5       
 4 8.16 ± 0.615


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed