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Study Information
Study Attribute Value
CEBS Accession Number: 002-02950-0001-0000-9
Chemical Name: Tricresyl phosphate
CASRN: 1330-78-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 272835_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 03/27/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1038 434 0.418 8.68 26.0 0.000
Negative (Not Specified) 
0         
 50 1034 432 0.418 8.64 26.0 -0.076
Test Chemical Tricresyl phosphate 
 0.05      
 50 1038 475 0.458 9.50 26.0 9.447 
 0.16      
 50 1032 444 0.430 8.88 26.0 2.899 
 0.5       
 50 1048 435 0.415 8.70 26.0 -0.726 
1.6       
 50 1043 394 0.378 7.88 26.0 -9.652 
5         
 50 1018 428 0.420 8.56 26.0 0.555 
16         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.01      
 50 1039 1865 1.795 37.30 26.0 329.310
Trend: -1.456        
Probability: 0.927        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 03/27/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1044 507 0.486 10.14 26.0 3.794
Dimethyl Sulfoxide 
0         
 50 1043 488 0.468 9.76 26.0 0.000
Test Chemical Tricresyl phosphate 
16         
 50 1041 447 0.429 8.94 26.0 -8.226 
50         
 50 1045 446 0.427 8.92 26.0 -8.781 
160         
 50 1041 468 0.450 9.36 26.0 -3.914 
500         
 50 1046 458 0.438 9.16 26.0 -6.417 
1600         
 50 1045 418 0.400 8.36 26.0 -14.508 
5000         
 50 1036 501 0.484 10.02 29.0 3.358 
5000         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Cyclophosphamide 
1.5       
 50 1036 2341 2.260 46.82 26.0 382.954
Trend: 0.023        
Probability: 0.491