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Study Information
Study Attribute Value
CEBS Accession Number: 002-03018-0011-0000-6
Chemical Name: Ziram
CASRN: 137-30-4
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 880520_SCE
Study Result: Negative (Nonstandard Protocol)


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 01/14/91 24 Mouse Male B6C3F1 Bone Marrow subcutaneously implanted x 1,  24 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 3.03 ± 0.311
Test Chemical Ziram 
2.5       
 4 3.19 ± 0.125
  
5         
 4 4.49 ± 0.682
  
10         
 4 3.54 ± 0.357
Positive Control Dimethylbenzanthracene 
2.5       
 4 6.48 ± 0.731


Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 05/02/89 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 7.25 ± 0.977
Test Chemical Ziram 
2.5       
 4 6.50 ± 1.198
  
5         
 4 5.47 ± 0.336
  
10         
 4 5.69 ± 0.646
Positive Control Dimethylbenzanthracene 
2.5       
 4 9.00 ± 1.049


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed