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Study Information
Study Attribute Value
CEBS Accession Number: 002-03050-0015-0000-6
Chemical Name: bis(2-Chloro-1-methylethyl) ether
CASRN: 108-60-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 500655_SCE
Study Result: Negative


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 09/12/88 42 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  42 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 4.23 ± 0.271
Test Chemical bis(2-Chloro-1-methylethyl) ether 
37.5       
 4 5.41 ± 0.617
  
75         
 4 4.41 ± 0.342
  
150         
 4 4.40 ± 0.388
Positive Control Dimethylbenzanthracene 
2.5       
 4 12.14 ± 0.381


Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 02/15/89 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 4.35 ± 0.381
Test Chemical bis(2-Chloro-1-methylethyl) ether 
37.5       
 4 5.98 ± 0.983
  
75         
 4 4.44 ± 0.201
  
150         
 4 4.53 ± 0.293
Positive Control Dimethylbenzanthracene 
2.5       
 4 8.21 ± 0.303


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed