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Study Information
Study Attribute Value
CEBS Accession Number: 002-03143-0011-0000-5
Chemical Name: o-Toluidine hydrochloride
CASRN: 636-21-5
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 938330_SCE
Study Result: Positive


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 06/26/85 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Dimethyl Sulfoxide 
 0         
 4 3.35 ± 0.206
Test Chemical o-Toluidine hydrochloride 
150         
 4 4.51 ± 0.288
  
300         
 4 6.13 ± 0.689
  
600         
 4 6.47 ± 0.358
Positive Control Mitomycin-C 
 0.5       
 4 9.03 ± 0.821


Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 08/01/88 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Phosphate Buffered Saline 
 0         
 4 4.25 ± 0.568
Test Chemical o-Toluidine hydrochloride 
450         
 4 8.49 ± 1.172
  
600         
 3 6.35 ± 0.338
Positive Control Mitomycin-C 
1         
 4 6.76 ± 0.169


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed