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Study Information
Study Attribute Value
CEBS Accession Number: 002-03143-0012-0000-6
Chemical Name: o-Toluidine hydrochloride
CASRN: 636-21-5
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 938330_CA
Study Result: Not a Valid Test

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 08/21/85 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.8555
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Mitomycin-C 
1         
 8 2.75 ± 1.19 0.1101
Test Chemical o-Toluidine hydrochloride 
150         
 8 0.75 ± 0.37 0.8427
  
300         
 7 1.14 ± 0.59 0.6647
  
600         
 7 0.57 ± 0.37 0.8916
Vehicle Control No Stressor 
 0         
 8 1.50 ± 0.63 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 05/27/87 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.0570
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Mitomycin-C 
1         
 8 3.25 ± 0.92 0.4195
Test Chemical o-Toluidine hydrochloride 
150         
 8 2.50 ± 0.91 0.6673
  
300         
 8 5.50 ± 1.68 0.0398
  
600         
 7 4.57 ± 0.95 0.1287
Vehicle Control No Stressor 
 0         
 8 3.00 ± 1.36 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed