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Study Information
Study Attribute Value
CEBS Accession Number: 002-03221-0002-0000-2
Chemical Name: tris(2-Ethylhexyl) ester phosphorous acid
CASRN: 301-13-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 560845_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 03/18/1986    Harvest Time: 20 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Ethanol 
0         
 200 2 0.010 1.0 2 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: tris(2-Ethylhexyl) ester phosphorous acid 
250         
 200 4 0.020 2.0 1 0.005 0.5 3 0.015 1.5 0 0.000 0.0 
625         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0 
1250         
 200 4 0.020 2.0 0 0.000 0.0 4 0.020 2.0 0 0.000 0.0 
1875         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 200 28 0.140 12.5 11 0.055 5.5 17 0.085 8.0 0 0.000 0.0
Mitomycin-C 
 0.08      
 25 25 1.000 52.0 4 0.160 12.0 21 0.840 48.0 0 0.000 0.0
Trend: 0.319 -1.819 1.491  
Probability: 0.375 0.966 0.068  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 03/18/1986    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Ethanol 
0         
 200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0
Test Chemical: tris(2-Ethylhexyl) ester phosphorous acid 
2500         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0 
3750         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 
5000         
 200 8 0.040 3.0 1 0.005 0.5 7 0.035 2.5 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 200 28 0.140 12.5 7 0.035 3.5 21 0.105 9.0 0 0.000 0.0
Cyclophosphamide 
37.5       
 25 18 0.720 44.0 7 0.280 28.0 11 0.440 32.0 0 0.000 0.0
Trend: 1.233 0.000 1.507  
Probability: 0.109 0.500 0.066