
-   The expression of Cdkn1a gene was diminished in the liver of MOD-1 mice, which lack the ME1 protein, compared to wild type mice. The diminished expression of Cdkn1a in MOD-1 mice was associated with reduced hepatosteatosis. The study was conducted on female C57BL/6 wild type and MOD-1 mice [PMID: 37047583].
-   The delivery mode strongly influenced placental gene expression, especially for CDKN1A (p21) and CDKN1B (p27), which were significantly upregulated in response to labor. Interfering with p21 influences multiple pathways related to the pathogenesis of preeclampsia (PE) [PMID: 34571867].
-   The Cdkn1a is acutely upregulated in the mouse mode of glycerol-induced acute kidney injury (AKI). Elevated expression was found to be independent of p53 pathway [PMID: 30698046].
-   p21 mRNA expression was induced in rat liver by administration of phenobarbital. mRNA level elevation was followed by a marked elevation of proliferating cell nuclear antigen (PCNA) and apoptotic indices [PMID: 11872643].
-   The p21 and caspase-3 mRNA expressions were significantly upregulated in the livers of rats injected with streptozotocin in the model of diabetes [PMID: 36818894].
-   Expression of p21 was elevated in a biphasic manner in a rat model of liver regeneration by a partial hepatectomy. The enhanced expression was observed during G1 phase and following S phase. Hepatic p21 mRNA was also induced by dietary protein deprivation in normal mice [PMID: 9049198].
-   p21 mRNA was upregulated with a perifocal pattern after ischemia induced by occlusion of the middle cerebral artery in rats. The ischemic regions themselves failed to show significant upregulation [PMID: 10925146].
-   The expression of p53 and p21 mRNA was concurrently up-regulated in the alveolar epithelial cells after intratracheal instillation of bleomycin in mouse model of pulmonary fibrosis [PMID: 10657022].
