
-   IL-17A: IL-17A induced the expression of ADAMTS-1 and increased the proliferation of cultured cardiac fibroblasts isolated from 3-day old Wistar rats [PMID: 23977238].
-   IL-1B: Interleukin-1beta stimulation transcriptionally downregulated ADAMTS1 in chondrosarcoma cells [PMID: 16949904].
-   TIMP-2 and TIMP-3: ADAMTS-1 is partially inhibited by inhibitor of metalloproteinases 2 and 3 (TIMP-2 and TIMP-3) [PMID: 12054629].
-   ADAMTS-1 mRNA could be induced by stimulating colon 26 cells with an inflammatory cytokine, interleukin-1. Intravenous administration of lipopolysaccharide in mice selectively induced ADAMTS-1 mRNA in kidney and heart [PMID: 8995297].
-   An anxiogenic drug, FG 7142, induced an increase in mRNA of Adamts1 in the hippocampus of adult mice [PMID: 22913326].
-   Ectopic expression of SP1 and USF transcription factors resulted in the decrease in ADAMTS1 transcriptional activity in normoxic condition. However, overexpression of SP1 and USF led to the increase of ADAMTS1 gene expressions at mRNA and protein level in hypoxic condition in hepatoma cells [PMID: 26299656].
-   Prodigiosin down-regulates the expression of miR-410 and TGF-beta1, up-regulates ADAMTS1 mRNA in lung tissue of a pulmonary fibrosis rat model and alleviates pulmonary fibrosis symptoms [PMID: 30157485].
-   ADAMTS1 mRNA and protein levels were increased in a mouse model of ischemia-induced retinal neovascularization, and VEGF induced time- and dose-dependent increases in ADAMTS1 mRNA and protein expression in endothelial cells [PMID: 16936124].
