
-   Gene expression of Ephx1 (encoding for mEH protein) was increased 1.35-fold in soluble epoxide hydrolase (sEH) KO liver in mice. mEH appears to play a leading role in the hydrolysis of 8,9-EET and 9,10-EpOME and contributes to the hydrolysis of other FA epoxides [PMID: 28975360].
-   Targeted inactivation of mouse Bsep produces milder persistent cholestasis due to detoxification of bile acids. The expression of microsomal epoxide hydrolase (mEH), a synonym for EPHX1, is elevated in Bsep (-/-) mice fed a cholic acid (CA)-enriched diet. Bile acids appear to upregulate the expression of mEH in Bsep (-/-) mice [PMID: 24399466].
