
-   Dig2 is a novel stress response gene, as its mRNA is induced in response to a variety of cellular stressors including thapsigargin, tunicamycin, and heat shock. Dig2 mRNA was up-regulated after treatment with the apoptosis-inducing chemotherapeutic drug etoposide [PMID: 12736248].
-   RTP801 gene is upregulated by hypoxia. Hypoxia induction of the RTP801 promoter is mediated by Sp1 [PMID: 15180327].
-   Elk-1 and C/EBP are involved in transcriptional regulation of the RTP801 gene by arsenite, a heavy metal that is linked to carcinogenesis in humans [PMID: 16008523].
-   RTP801 is an important retinoic acid (RA)-regulated gene involved in myeloid differentiation. The myeloid-specific, differentiation-related transcription factor C/EBPepsilon induces RTP801 gene expression [PMID: 17379067].
-   DNA damaging agent, methyl methanesulfonate (MMS), induces RTP801 transcription in human keratinocytes. And C/EBP is involved in the transcriptional regulation of the RTP801 gene by MMS [PMID: 15751966].
-   Redd1 gene is transactivated by the ATF4 and C/EBP family of transcription factors, leading to mTOR inhibition in response to oxidative and ER stress [PMID: 19439225].
