
-   The low miR-873-5p expression predicted poor survival in colon cancer patients. miR-873-5p inhibits the progression of colon cancer via repression of tumor suppressor candidate 3 (TUSC3)/AKT signaling [PMID: 31039290].
-   Vitamin D treatment induced TUSC3 mRNA expression in human PC-3 prostate cancer cells, and silencing TUSC3 promoted prostate cancer cell growth and migration [PMID: 29088772].
-   Tumour suppressor candidate 3 (TUSC3) is a target gene of miR-UL112-3p. TUSC3 gene expression was inversely correlated with miR-UL112-3p expression in GBM tissues. miR-UL112-3p promotes glioblastoma progression via direct targeting TUSC3 in GBM [PMID: 28303930].
-   Downregulation of microRNA-320a inhibits proliferation and induces apoptosis of retinoblastoma cells via targeting TUSC3 [PMID: 32934674].
-   Wnt/c-Myc signaling upregulates epigenetic factor UHRF1, which in turn downregulates TUSC3 expression in colon cancer cells. UHRF1 suppresses TUSC3 expression by interacting with methylated H3K14 and thereby suppressing the acetylation of H3K14 by the histone acetyltransferase KAT7 [PMID: 31582837].
-   Overexpression of two microRNAs (miR-181a-5p and miR-30e-5p) leads to reduced protein levels of Tumor Suppressor Candidate 3 (TUSC3) in breast cancer cells [PMID: 28288641].
-   MicroRNA-132 induces temozolomide resistance and promotes the formation of cancer stem cell phenotypes by targeting TUSC3 in glioblastoma [PMID: 28901390].
