
-   PPL can be highly induced by biomechanical stress in saphenous vein coronary artery bypass grafts and in cultured cells grown under a cyclic stretch [PMID: 19211270].
-   The use of a cDNA microarray identified an Akt-binding protein, periplakin, as a novel target of cyclin A2 in endometrial carcinoma cells. The cyclin A2-induced up-regulation of periplakin was mediated via direct binding of Sp1 to the promoter that was activated by cyclin A2 along with chromatin remodeling involving CBP/p300 [PMID: 19583808].
-   Caspase 6 disconnects intermediate filament-binding domain of periplakin from its actin-binding N-terminal region by cleaving at an unconventional recognition sequence TVAD [PMID: 15654952].
