
-   Compared to wild-type counterparts, hindlimb immobilization in Zeb1-deficient mice resulted in enhanced muscle atrophy and higher expression of 4Ebp1 [PMID: 30304480].
-   The Neurotrophin 3 (NT-3) gene therapy increases muscle fiber diameter in the neurogenic muscle of TremblerJ (Tr J ) mice through increased phosphorylation of 4E-BP1 and direct activation of mTOR pathway [PMID: 29523879].
-   Deletion of 4E-BPs (4E-BP1 and 4E-BP2) was associated with perturbed energy metabolism in skeletal muscle and could have beneficial effects on skeletal muscle mass. This study identified 4E-BP1 as potential target for the treatment of sarcopenia, a condition characterized by loss of muscle mass/function during aging [[PMID: 30927336](https://www.ncbi.nlm.nih.gov/pubmed/30927336)].
-   Increased 4E-BP1 expression protects against diet-Induced obesity and insulin resistance in male mice [PMID: 27498874].
