
-   Arctiin, a lignan glycoside, inhibits cervical cancer cell migration and invasion through suppression of S100A4 expression via PI3K/Akt pathway [PMID: 35214097].
-   Calcimycin was identified as a transcriptional inhibitor of S100A4. S100A4-induced cell motility and metastasis is restricted by the Wnt/beta-catenin pathway inhibitor calcimycin in colon cancer cells [PMID: 21795396].
-   The mRNA and protein levels of S100A4 expression increased in pulmonary arterial smooth muscle cells (PASMCs) after hypoxic stimulation. S100A4 is predominantly expressed in hypoxic rhomboid cells (R-SMCs), and regulated by the activation of JAK2-STAT3 signal pathway, which is dependent on hypoxia-induced HIF-1alpha expression [PMID: 22561747].
-   Serotonin or 5-hydroxytryptamine (5-HT) elevated S100A4/Mts1 mRNA and protein levels in human pulmonary artery smooth muscle cells (hPA-SMC). 5-HT1B receptor and serotonin transporter (SERT) are codependent in regulating S100A4/Mts1, a gene associated with pulmonary vascular disease [PMID: 16002749].
-   S100A4 is a direct beta-catenin/T-cell factor (TCF) target, induces migration and invasion in vitro and metastasis in vivo, and has value for prognosis of metastasis formation in colon cancer patients [PMID: 17101323].
