
-   Protein Accession: Q99988
-   Size: amino acids: 308 amino acids
-   Molecular mass: 34140 Da
-   Domains: Cystine-knot_cytokine, TGF-b_C, TGF-beta-rel
-   Blocks: Transforming growth factor beta (TGF-beta) Growth factor cystine knot superfamily signature
-   Family: Belongs to the TGF-beta family.
-   The cryo-EM structures of the extracellular region ternary complexes of GDF15/GFRAL/RET, GDNF/GFRalpha1/RET, NRTN/GFRalpha2/RET and ARTN/GFRalpha3/RET reveal that all four ligand/co-receptor pairs induce a specific dimerization mode of RET that brings the two kinase domains into close proximity for cross-phosphorylation, with the NRTN/GFRalpha2/RET dimeric complex further packing into a tetrameric assembly, which regulates the endocytosis of RET [PMID: 31535977].
-   Macrophage inhibitory cytokine-1 (MIC-1), a divergent member of the transforming growth factor-beta (TGF-beta) superfamily, does not require its propeptide for correct folding or secretion, with a region between residues 56 and 78 identified as crucial for the interaction between the propeptide and the mature peptide, suggesting a model for TGF-beta superfamily protein folding [PMID: 11278594].
