
-   Protein Accession: P08476
-   Size: 426 amino acids
-   Molecular mass: 47442 Da
-   Domains: Cystine-knot_cytokine, Inhibin_betaA, TGF-b_C, TGF-b_propeptide, TGF-beta-rel, TGFb_CS
-   Family: Belongs to the TGF-beta family
-   Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition [[https://www.uniprot.org/uniprotkb/P08476/entry#function](https://www.uniprot.org/uniprotkb/P08476/entry#function)].
-   The human activin beta A gene is composed of two exons interrupted by the 9-kb intron. The TATA, CCAAT and CT-stretch sequences were found in the 5'-flanking region of the gene. An intronic sequence contained SV40 enhancer core element in the vicinity of the exon 1. In the 3'-flanking region, we identified eight consensus polyadenylation sequences, five ATTTA motifs, CA element consisting of (CA)14, AP-1 binding site and two SV40 enhancer core elements [PMID: 1777673].
-   Activin A, a homodimer of inhibin betaA, inhibits DNA synthesis in hepatocytes [PMID: 12230121]. Activin A stimulates type IV collagenase (matrix metalloproteinase-2) production in mouse peritoneal macrophages [PMID: 10975808].
