
-   The POSTN gene was found to be highly expressed in pro-fibrotic fibroblasts of acutely infarcted, and chronically failing human hearts, which are associated with tissue fibrosis and organ dysfunction [PMID: 36747878].
-   Postn exhibited up-regulated expression in acute myocardial infarction (AMI) mice and hypoxia-treated neonatal mouse cardiomyocytes (NMCMs). Periostin renders cardiomyocytes vulnerable to acute myocardial infarction via pro-apoptosis [PMID: 35104050].
-   Gene expression level of POSTN was significantly higher in myocardial tissue from patients with dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM) compared to normal heart tissue [PMID: 35282347].
-   Periostin expression is upregulated and associated with myocardial fibrosis in human failing hearts [PMID: 24219836]. Postn mRNA was increased in TGFbeta1 treated non-heart failure and heart failure sinoatrial node (SAN) fibroblasts [PMID: 33874740].
