
-   Suppression of RhoBTB1 may be responsible for colon tumorigenesis and cutaneous squamous cell carcinoma, which was inhibited directly by miR-31[PMID: 23258531, PMID: 28454216].
-   RhoBTB1 is a substrate for ROCK1. The Rho domain of RhoBTB1 binds to the coiled-coil region of ROCK1 close to its kinase domain. This interaction was related to inhibitory role in cancer cell invasion [PMID: 31431478].
