
-   The AKIP1 gene was identified as differentially expressed in both in vitro and in vivo models of heart failure and hypertrophy in rats. The AKIP1 gene was associated with heart failure and hypertrophy [[PMID: 22353257](https://www.ncbi.nlm.nih.gov/pubmed/22353257), [PMID: 27168795](https://www.ncbi.nlm.nih.gov/pubmed/27168795)].
-   Upregulation of AKIP1 gene was associated with physiological cardiac hypertrophy in a transgenic mouse model. The study was conducted on a transgenic mouse model with cardiac-specific overexpression of miR-223 [[PMID: 27226563](https://www.ncbi.nlm.nih.gov/pubmed/27226563)].
-   AKIP1 mRNA and protein levels increased in hypertrophic cardiomyocytes under conditions of sustained cardiac stress, including pressure overload and after myocardial infarction and in vitro in phenylephrine (PE) stimulated neonatal rat ventricular cardiomyocytes (NRVCs). AKIP1 stimulates cardiomyocyte growth via the Akt pathway [PMID: 24169435].
