
-   The murine CrAT promoter displays some characteristics of a housekeeping gene due to its lack of a TATA-box, it is very GC-rich, and harbors two Sp1 binding sites. Analysis of the promoter activity of CrAT by luciferase assays uncovered a L-carnitine sensitive RXRalpha binding site, which also showed sensitivity to application of anti-PPARalpha and anti-PPARbp antibodies. Results indicated a cooperative interplay of L-carnitine and PPARalpha in transcriptional regulation of murine CrAT [PMID: 24962334].
