
-   BTG2 is one of six mitochondria-related genes that were differentially expressed in melanoma B16-F1 cells treated with quercetin versus controls [PMID: 37869567].
-   Proliferation and survival of mature T cells were significantly increased in the TIS21 knockout than the wild type (WT3)e cells, indicating that TIS21 inhibits the rate of mature T cell proliferation and its survival. TIS21 exhibits antiproliferative and proapoptotic effects in mature T cells, and differentially affects the frequencies of granzyme B+ CD8+ T-cells and CD107a+ CD8+ T-cells, thus transiently regulating in vivo anti-tumor immunity in B16-melanoma. [PMID: 25088256].
-   BTG2 expression was downregulated in skin cancer cell lines. Overexpression of BTG2 significantly inhibited cell proliferation, cell cycle progression, and the invasion and migration of skin cancer cells [PMID: 27510158].
-   Skin aging in long-lived naked mole-rats (NMRs) is accompanied by increased gene expression of longevity-associated and tumor-suppressor genes, including Btg2. These data suggest that specific features in the NMR skin aging transcriptome might contribute to the resistance of NMRs to spontaneous skin carcinogenesis [PMID: 35691364].
