
-   The mRNA expression of MMP12 is significantly upregulated in induced sputum of asthmatic patients and significantly correlated with eosinophilic-related indicators, which could suggest that MMP12 can act as a diagnostic biomarker for asthma. [PMID: 34384863]
-   The expression of MMP12 in alveolar macrophage was the third most highly induced gene in smokers than in nonsmokers. [PMID: 16166618]
-   Significantly elevated MMP-12 gene expression level in sputum following wood smoke exposures. [PMID: 24625755]
-   Elevated gene expression of MMP-12 in human sarcoidosis samples. [PMID: 29212802]
-   MMP12 is up-regulated at the gene and protein levels in adult-induced emphysema, asthma, and lung cancer models following *in utero* second-hand smoke (SHS) exposure in mice. [PMID: 34912233]
-   MMP12 gene expression is upregulated in lung squamous cell carcinoma (LUSC) and high expression of MMP12 serves as a risk factor for LUSC patients. [PMID: 37601247, PMID: 32411535]
-   P. murina exposure induced MMP-12 mRNA expression in mice lungs and alveolar macrophages (AMs). [PMID: 22773692]
-   Asbestos transcriptionally up-regulates MMP-12 in murine lung via an EGFR (or other growth factor receptors)/PI3K/PKCdelta/ERK1/2 pathway. [PMID: 16571779]
-   Pneumococcal infection in mice with elastase-induced emphysema had increased mortality and MMP-12 gene expression in the lung. Treatment with the MMP inhibitor ONO-4817 dramatically suppressed both mortality rate and emphysema progression. [PMID: 26563237]
