
-   AKR7A3 expression was downregulated in pancreatic ductal adenocarcinoma (PDAC) compared with adjacent normal tissues, and the lower AKR7A3 expression was related to poor prognosis. AKR7A3 could be a potential diagnostic marker for PDAC, especially in the early stages [PMID: 36951402].
-   The expression levels of AKR7A3 in human gastric cancer (GC) tissues were lower in GC tissues than in normal tissue. Differentially expressed genes (AKR1B10, AKR1C1, AKR1C2, AKR7A3, and AKR6A5) were significantly correlated with the immune infiltration level. Survival analysis showed that increased mRNA levels of AKR7A3 and AKR1B10 or reduced levels of AKR6A5 was expected to have higher overall survival (OS), first progression (FP) survival, and postprogression survival (PPS) rates and a better prognosis [PMID: 36827074].
