
-   The expression of CCL2 was found to be upregulated in a murine model of LPS-induced acute lung injury (ALI). This upregulation was reversed by pre-treatment with anti-inflammatory agents dexamethasone and soloxolone methyl (SM) [PMID: 34807957].
-   CCL2 was identified as a differentially expressed gene in individuals with Chronic obstructive pulmonary disease (COPD) compared to healthy individuals. It was related to inflammation or immunity, or tissue-specific expression in lung tissue. In rat lung tissue from rats, CCL2 mRNA expression was upregulated in the COPD model group vs control samples [PMID: 34804123].
-   Hyperoxia-induced inflammation contributes significantly to developmental lung injury and bronchopulmonary dysplasia (BPD) in preterm infants. Gene expression analysis also indicated increased expression of pro-inflammatory genes such as CXCL1, CCL2 and IL-6 in the lungs of hyperoxia-exposed wild type mice and metabolic regulators such as HMGCS2 and SIRT3 in the lungs of PAF receptor knockout KO mice, suggesting that PAF signaling may modulate bronchopulmonary dysplasia risk through changes in pulmonary inflammation and/or metabolic reprogramming in preterm infants [PMID: 36993203].
-   An animal model with repeated lipopolysaccharide (LPS) administration into the airways of immature mice to simulate prolonged airway exposure to gram-negative bacteria lead to induced persistent hypoalveolarization. Results showed upregulated the expression of lung pro-inflammatory cytokines and chemokines (CCL2, CCL7, CXCL1, and CXCL2), while the expression of genes involved in lung alveolar and mesenchymal cell development were decreased [PMID: 33117383].
-   Patients with high peri-tumoral lung field extratumoral alveolar macrophages (p-exAMs) showed significantly shorter recurrence-free (RFS) and shorter overall survival (OS) than those with low p-exAMs, whereas there was no survival difference between patients with high distant lung field (d-exAMs) and those with low d-exAMs. Alveolar macrophages (AM) in the tumor periphery expressed significantly higher levels of IL-10 and CCL2 mRNA than those in the distant segment. This study suggests that p-exAMs should be considered as a tumor-promoting component in the tumor microenvironment [PMID: 37264761].
-   The mRNA expression levels of CXCL5, CCL2, and CCL7 moderately or strongly correlated with inflammation in rat lungs tissues following intratracheal instillation of nanomaterials [PMID: 33076408].
-   Small sputum macrophages represent highly active cells that increase in the airways of patients with inflammatory diseases such as chronic obstructive pulmonary disease (COPD). In small sputum macrophages from COPD patients, gene expression data shows induction of a specific set of CCL chemokines, such as CCL2, CCL7, CCL13 and CCL22, which is distinct from what can be induced by LPS [PMID: 21327296].
-   In a mouse model of experimental asthma following dsRNA challenges, lung tissue mRNA expression of CCL2 significantly increased [PMID: 26879906].
