
-   Murine prion protein (moPrP) induced a strong antibacterial response with Slpi mRNA over expression in the colon of male FVB/N mice. This effect is enhanced with the presence of detoxified lipopolysaccharide (D-LPS). This suggests that moPrP antibacterial properties may be related to its ability to enhance the expression of *Slpi* gene [PMID: 35093722].
-   A quercetin-enriched diet induced Slpi gene expression in mice ileum and colon [PMID: 28684695].
-   SLPI mRNA level was selectively increased in ulcerative colitis (UC) inflamed tissue, but not in Crohn's disease (CD) inflamed tissue [PMID: 17200145, PMID: 24937444].
-   SLPI is one of the significantly up-regulated genes in the colons of *Clostridium difficile*\-infected (CDI) mice [PMID: 23668260].
-   SLPI mRNA level was significantly reduced in the distal colon of appendicitis-appendectomy (AA) mice compared to the distal colon of sham-sham (SS) mice [PMID: 21707591].
