
-   Protein Accession: P09341
-   Size: 107 amino acids
-   Molecular mass: 11301 Da
-   Domains: Chemokine_CXC, Chemokine_CXC_CS, Chemokine_IL8-like_dom, CXC_Chemokine_domain, Interleukin_8-like_sf
-   Blocks: Interleukin-8 signature
-   Family: Belongs to the intercrine alpha (chemokine CxC) family
-   The chemokines Cxcl1 and Cxcl2, crucial for neutrophil migration, form heterodimers with distinct binding characteristics to free and immobilized glycosaminoglycans (GAGs), suggesting that the intrinsic asymmetry of the heterodimer structure and its differential binding to GAGs regulate chemokine function [PMID: 33463672].
-   CINC-1, also known as CXCL1, is a cytokine-induced neutrophil chemoattractant. CXCL1 is released by the liver as an acute-phase protein following injury or infection. CXCL1 is associated with increases in neutrophil numbers within the liver and within the circulation, which mediates inflammatory hyperalgesia in rats via release of sympathomimetic amines [PMID: 12709409, PMID: 12517731].
