
-   PPAR gamma activation (by rosiglitazone or troglitazone) induced adipophilin gene expression in human colonic epithelial cells [PMID: 15764152]. AS002 (a PPARgamma agonist) and rosiglitazone increased Adipophilin mRNA expression (3-fold) and decreased TNF-alpha, IL-1beta, and IL-13 levels in human ulcerative colitis (UC) biopsies. These data suggest that PPARgamma has potential anti-inflammatory effects in UC mediated by induction of Adipophilin expression [PMID: 29529198].
-   Deletion of the PLIN2 gene modulates gut microbial community structure and abrogates long-term deleterious effects of a high-fat diet in mice. Perilipin-2 modulates dietary fat-induced microbial global gene expression profiles in the mouse intestine [PMID: 28877764].
-   Mice with targeted disruption of the PPARgamma gene in intestinal epithelial cells displayed decreased gene expression of ADRP and increased susceptibility to dextran sodium sulphate (DSS) induced colitis [PMID: 16547072].
