
-   Knockdown of RAB13 suppressed HCC cell proliferation and metastasis by inhibiting the PI3K/AKT signaling pathway, CDK1/CDK4 expression, and epithelial-mesenchymal transition. RAB13 interacts with CDK1 in hepatocellular carcinoma, leading to changes in cell proliferation and metastasis [PMID: 36901767].
-   In hepatocellular carcinoma (HCC) cells, miR-195-5p targeted and reduced CDK1 expression, inhibited the G1 phase-to-S phase transition, induced DNA damage response, and inhibited DNA replication and proliferation [PMID: 36607481].
-   Lycorine significantly promoted the decrease both in protein and mRNA expression of CDK1. CDK1 might serve as a potential target for lycorine against hepatocellular carcinoma [PMID: 34673013].
-   Up-regulation of RhoB could induce cell cycle arrest in G2/M phase and led to cell cycle regulators (CyclineB1,CDK1) aberrant expression in clear cell renal cell carcinoma (ccRCC) cells [PMID: 27384222].
-   TGFbeta downregulated the expression of several G2 checkpoint kinases including cdc2 and cyclin B1 [PMID: 17459720].
