
-   Entrez Gene Summary for HAVCR1 Gene: The protein encoded by this gene is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. The encoded protein may be involved in the moderation of asthma and allergic diseases. The reference genome represents an allele that retains a MTTVP amino acid segment that confers protection against atopy in HHAV seropositive individuals. The protein is a receptor for multiple other viruses, including Ebola virus, Marburg virus, Dengue virus, and Zika virus and is a possible entry factor for SARS-CoV-2 and other coronaviruses. [provided by RefSeq, Sep 2021]
-   GeneCards Summary for HAVCR1 Gene: HAVCR1 (Hepatitis A Virus Cellular Receptor 1) is a Protein Coding gene. Diseases associated with HAVCR1 include Hepatitis and Hepatitis A. Among its related pathways are Disease and SARS-CoV-1 Infection. Gene Ontology (GO) annotations related to this gene include virus receptor activity. An important paralog of this gene is TIMD4.
-   UniProtKB/Swiss-Prot Summary for HAVCR1 Gene: Phosphatidylserine receptor that plays an important functional role in regulatory B-cells homeostasis including generation, expansion and suppressor functions. As P-selectin/SELPLG ligand, plays a specialized role in activated but not naive T-cell trafficking during inflammatory responses [PMID: 24703780]. Controls thereby T-cell accumulation in the inflamed central nervous system (CNS) and the induction of autoimmune disease [PMID: 24703780]. Also regulates expression of various anti-inflammatory cytokines and co-inhibitory ligands including IL10. Acts as regulator of T-cell proliferation. May play a role in kidney injury and repair [PMID: 17471468]. Acts as a receptor for Hepatitis A virus, Ebolavirus and Marburg virus by binding exposed phosphatidyl-serine at the surface of virion membrane [PMID: 21536871]. Serves as a dual receptor for Ebolavirus by also interacting with envelope glycoprotein GP [PMID: 26487564]. Acts as a receptor for Dengue virus by binding exposed phosphatidyl-serine at the surface of virion membrane [PMID: 23084921]. TIM1 and Dengue virus are co-internalized during virus entry [PMID: 29742433]. Acts as a receptor for Zika virus by binding to envelope protein E. Plays a positive role in Chikungunya virus cell entry.
