
-   MT2A mRNA expression were related to wound age in the contused skeletal muscle of rats. As the extension of wound age, the relative expression of MT2A mRNA at 1 h, 6 h, 12 h and 18 h after contusion demonstrated upgrade tendency until its expression levels peak at 18 h. When time extends to 24 h after injury, the expression of MT2A decreased. The MT2A mRNA expression levels increased again at 30 h and then decreased [PMID: 29231000].
-   Metallothionein-1 and -2 expression and total zinc are increased in sarcopenic muscle. Concomitant abrogation of metallothioneins 1 and 2 results in activation of the Akt pathway and increases in myotube size, in type IIb fiber hypertrophy, and ultimately in muscle strength. These results suggest that blockade of metallothioneins 1 and 2 constitutes a promising approach for the treatment of conditions which result in muscle atrophy [PMID: 27956698].
