
-   In prostate cancer, amplification or induced expression of cMyc has been shown to promote its binding to the 4E-BP1 gene promoter and increase expression [PMID: 19773438].
-   ATF4 directly activates the Eif4ebp1 gene. ATF4 mediates induction of 4E-BP1 in pancreatic beta-cells under endoplasmic reticulum stress [PMID: 18316032].
-   In pancreatic cancer cell lines, hypoxia-triggered induction of 4E-BP1 is dependent on HIF-1alpha and SMAD4 [PMID: 23175522].
-   Glycogen synthase kinase-3beta (GSK-3beta) phosphorylates and inactivates 4E-BP1. GSK-3beta positively regulates protein synthesis and cell proliferation through the regulation of translation initiation factor 4E-binding protein 1[PMID: 23584478].
