
-   Protein Accession: Q9NZC2
-   Size: 230 amino acids
-   Molecular mass: 25447 Da
-   Domains: Ig-like_dom_sf, Ig-like_fold, Ig_V-set
-   Blocks: Immunoglobulin subtype
-   Family: None
-   The total chemical synthesis of the 116 amino acid TREM2 ectodomain revealed that glycosylation at N79 is critical to the thermal stability of TREM2, a microglia-associated gene implicated in Alzheimer's disease, and this synthetic TREM2 enhanced microglial phagocytosis, proliferation, and survival [PMID: 37235776].
-   Forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding [PMID: 10799849]. Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia [PMID: 27477018, PMID: 29518356]. Acts as a receptor for lipoprotein particles and for apolipoproteins and enhances their uptake in microglia [PMID: 27477018]. Binds phospholipids (preferably anionic lipids) such as phosphatidylserine, phosphatidylethanolamine, phosphatidylglycerol and sphingomyelin [PMID: 29794134]. Required for microglial phagocytosis of apoptotic neurons [PMID: 24990881]. In dendritic cells, it mediates up-regulation of chemokine receptor CCR7 and dendritic cell maturation and survival [PMID: 11602640]. Involved in the positive regulation of osteoclast differentiation [PMID: 12925681].
