
-   Decreased FCN2 gene expression in human hepatocellular carcinomas (HCC)s predicts poor prognosis. Relative FCN2 mRNA expression was significantly higher in HCC without metastasis that HCC with metastasis [PMID: 27177473].
-   The polymorphism in the ficolin-2 gene (FCN2) was associated with a higher risk of infection and mortality after orthotopic liver transplantation [PMID: 20593422].
-   Expression of human ficolin-2 in hepatocytes confers resistance to infection by diverse hepatotropic viruses. Cell-to-cell spread of hepatitis C virus (HCV) was also inhibited in ficolin-2 expressing cells [PMID: 30747617]. Recombinant human L-ficolin directly neutralizes hepatitis C virus entry [PMID: 24854201]. Elevated serum activity of MBL and ficolin-2 as biomarkers for progression to hepatocellular carcinoma in chronic HCV infection [PMID: 30798068].
