
-   Overexpression of the secreted form of the CLU protein (sCLU) was associated with resistance to preoperative neoadjuvant chemotherapy in primary breast cancer [PMID: 23740447].
-   In the colon, overexpression of the secreted form of the CLU protein (sCLU) was found only in the cytoplasm of highly infiltrating tumors and metastatic nodes with a complete loss of the proapoptotic nuclear form (nCLU). The increased level of the secreted form and the disappearance of the nuclear unglycosylated isoform were directly connected to increased cell survival, aggressiveness, and enhanced metastatic potential [PMID: 14755245].
-   Increased clusterin expression is correlated with more aggressive biologic behavior and impaired survival in ovarian cancer [PMID: 20009887].
-   Clusterin expression is particularly high in the brain, where it binds to amyloid-beta (Abeta), possibly facilitating Abeta transport into the bloodstream. Its concentration in peripheral blood was identified as a potential biomarker for Alzheimer's disease (AD) and predicted retention of (11)C-Pittsburgh Compound B in the temporal lobe. [PMID: 22232000].
