
-   mTOR-independent 4E-BP1 phosphorylation is associated with colorectal cancer resistance to mTOR kinase inhibitors [PMID: 22262166]. 4E-BP1 expression is associated with clinical survival outcomes in colorectal cancer [PMID: 26204490].
-   4E-BP1 overexpression is strongly associated with prostate cancer. Expression of 4E-BP1 was elevated in prostate intraepithelial neoplasia (PIN, the pre-cancerous lesion of prostate cancer), and was significantly higher in prostate cancer as compared to normal tissue [PMID: 16652388].
-   4E-BP1 was also overexpressed in several large advanced breast cancers, overexpressed 4E-BP1 and eIF4G orchestrate a hypoxia-activated switch from cap-dependent to cap-independent mRNA translation that promotes increased tumor angiogenesis and growth [PMID: 17996713]. 4EBP1 and S6K2 are frequently co-expressed, and associated with a poor prognosis and endocrine resistance in breast cancer [PMID: 24131622].
-   Overexpressed eIF4E is functionally active in surgical margins of head and neck cancer patients through activation of the Akt/mTOR signaling pathway [PMID: 15355912].
-   4E binding protein 1 expression is inversely correlated to the progression of gastrointestinal cancers [PMID: 10785360].
-   4E-BP1 expression was increased in islets under ER stress in several mouse models of diabetes [PMID: 9884331]. 4E-BP1 contributes to diabetes-induced visual dysfunction [PMID: 26998719].
-   Phosphorylation of eIF4E by Mnk-1 enhances herpes simplex virus-1 (HSV-1) translation and replication in quiescent cells [PMID: 15075293].
-   4EBP1 as a biomarker for the efficacy of PI3K-AKT-mTOR inhibitors in glioblastoma [PMID: 28696243].
-   4E-binding protein phosphorylation and eukaryotic initiation factor-4E release are required for airway smooth muscle hypertrophy [PMID: 15901615].
