
-   Size: 498 amino acids
-   Molecular mass: 55395 Da
-   Protein Accession: Q9UBF9
-   Family: Belongs to the myotilin/palladin family
-   Domains: Basigin-like, Ig-like_dom, Ig-like_dom_sf, Ig-like_fold, Ig_I-set, Ig_sub, Ig_sub2
-   Myotilin, a component of the sarcomere, maintains Z-disk integrity through direct binding to F-actin and filamin C, mediated by its Ig domain pair, with sequence conservation analysis revealing motifs in Ig domains also found in I-band proteins and a highly conserved Glu344 critical to the inter-domain hinge mechanism, suggesting that the conformational plasticity of the Ig domain pair in its unbound form is part of the binding partner recognition mechanism [[PMID: 28638118]](https://www.ncbi.nlm.nih.gov/pubmed/28638118).
