
-   Colon cancer (CC) and obesity were accompanied by significant increased mRNA levels of NLRP3, NLRP6, ASC, IL1B and NOD2 in visceral adipose tissue (VAT) [PMID: 34880645].
-   IL-27 evoked differential gene expression of epithelial-derived innate immune responses (reduced IL1B and IL18, and increased IL33, HBD1, MUC1 and MUC2) in human colon epithelial cells. IL-27 induced epithelial barrier wound healing and increased proliferation following injury [PMID: 35336801].
-   Intestine tissues from patients with ulcerative colitis and mice with colitis have increased levels of IL1B mRNA and MIR200C-3p [PMID: 32569770].
-   GEPON (a synthetic tetradecapeptide) intraperitoneal injections significantly attenuated DSS-induced pathological manifestations in the large intestine in C57BL/6 mice. GEPON was shown to inhibit IL-1 and IL-6 mRNA expression in Ly6C+ monocytes sorted from the colon tissue [PMID: 32621844].
-   The expression of the FCGR3A and IL1B genes was significantly up-regulated in the inflamed colon region of Crohn's disease (CD) patients that are non-responsive to to anti-TNF therapy. Altered TNFRSF1B, FCGR3A, and IL1B genes expression can be a predictor of the primary non-response to anti-TNF therapy in CD patients [PMID: 33767696].
