
-   Glucocorticoids negatively regulate S100A8 and S100A9 in a c-Fos-dependent manner, influencing gene expression [PMID: 12082614].
-   The transcription factor C/EBPdelta is a central regulator of S100a8 and S100a9 expression. There are C/EBPdelta-binding sites within S100a8 and S100a9 promoter regions, and data indicates C/EBPdelta-dependent JMJD3-mediated demethylation of H3K27me3 is indispensable for the expression of S100a8 and S100a9 [PMID: 35543413].
-   The activation of the mRNA and protein expression levels for S100A8 induced by IL-1alpha in TR146 epithelial cells involves a mechanism by which the binding activity of C/EBPbeta to a specific site of the S100A8 promoter is increased [PMID: 30664211].
-   USF2 transcriptionally regulated S100A8 expression by directly binding to its promoter region. USF2 was identified as an important switch on the intracellular and extracellular S100A8 feedback loop in colorectal cancer [PMID: 33389821].
