
-   Significant changes in expression of 8 genes, including Tnfrsf12a, identified as hub genes associated with non-alcoholic steatohepatitis (NAFL) [PMID: 35559030].
-   The Fn14 immediate-early response gene is induced during liver regeneration and highly expressed in both human and murine hepatocellular carcinomas [PMID: 10751351].
-   TWEAK/FN14 promotes profibrogenic pathway activation in Prominin-1- expressing hepatic progenitor cells in biliary atresia (BA). Analysis of an RNA sequencing database of BA and normal control patients revealed significantly increased expression of FN14, and genes downstream of TNF signaling and non-canonical NFkappaB signaling pathways in BA infants. Infants who failed to achieve bile drainage after hepatoportoenterostomy had relatively higher levels of FN14 expression [PMID: 36626628].
