
-   NCAM-1 gene expression was found to be highly enriched in mature Purkinje cells of the ventricular conduction system. Mice deficient in NCAM-1 led to defects in Purkinje cell gene expression and ventricular conduction system patterning, as well as cardiac conduction disease. Inhibition of post-translational modification of NCAM-1 by polysialic acid, using ST8sia2 and ST8sia4 knockout mice, leads to disrupted trafficking of sarcolemmal intercalated disc proteins to junctional membranes and abnormal expansion of the extracellular space between apposing Purkinje cells [PMID: 34100064].
-   Upon examining the mRNA expression profiles for individuals with aortic aneurysm or aortic dissection, 9 hub genes of the transcriptome-wide association study results were identified via PPI network analysis, including RPS9, RPS18, RSRC1, DNAJC3, HBS1L, PRKCA, NCAM1, ITGB3, FTSJ3 [PMID: 34626721].
-   Analysis of miRNA-gene pairs were examined to identify biomarkers for the clinical and prognosis factors of myocardial infarction (MI) compared with angina patients. The genes CALCA, CDK6, MDM2, NRXN1, SOCS3, VEGFA, SMAD4, NCAM1, and hsa-miR-127-5p were thought to be potential diagnosis biomarkers for MI [PMID: 33224271].
