
-   Protein Accession: P18283
-   Size: 190 amino acids
-   Molecular mass: 21954 Da
-   Domains: Thioredoxin-like_sf, Glutathione_peroxidase, GPX_AS, GPX_CS
-   Blocks: Glutathione peroxidase
-   Family: Belongs to the glutathione peroxidase family
-   A selenoprotein that catalyzes reduction of hyrdoperoxides (H2O2, tert-butyl hydroperoxide, cumene hydroperoxide, linoleic acid hydroperoxide) by means of glutathione (GSH), which thereby becomes oxidized to GSSG and subsequently regenerated by glutathione reductase [PMID: 22758632].
-   GSHPx-GI mRNA was readily detected in human liver and colon, and occasionally in human breast samples, but not other human tissues including kidney, heart, lung, placenta, or uterus. In rodent tissues, GSHPx-GI mRNA is only detected in the gastrointestinal tract, and not in other tissues including liver [PMID: 8428933].
-   Compared to other GPx, RNA of GPx2 remained stable under marginal Se deficiency, making it higher ranking than other Se GPx [PMID: 19810021].
