
-   B4GALT4 mRNA expression level was significantly upregulated in hepatocellular carcinoma (HCC) tumors in comparison to normal samples, while no obvious changes in this gene expression were observed when comparing patients with cirrhosis and HCC, which may suggest that the dysregulation promoted pathological changes in normal liver tissue [PMID: 34270095].
-   B4GALT4 mRNA expression was downregulated in endometrial cancer (EC) tumor tissue compared to in normal endometrial tissues. Nine cell glycolysis associated genes (including B4GALT4) were found to be significantly related to overall survival of patients with EC [PMID: 31807118].
-   During postnatal development, UDP-Gal: GlcNAc(beta 1-4)-galactosyltransferase (4 beta-GT) activities were increased by 17-fold in the rat small intestine [PMID: 2497785].
-   Distinct expression patterns of the beta-1,4-galactosyltransferases were observed during testicular development in the mouse. Northern blot analysis revealed that beta4-GalT-I and beta4-GalT-IV were expressed mainly in newborn mouse testis [PMID: 12841642].
-   After three days of hyperosmotic culture of Chinese hamster ovary cells, nine genes including b4galt4 were differentially expressed over 1.5-fold of the control, and all these genes were down-regulated. The decreased expression of the genes with roles in the N-glycan biosynthesis pathway correlated with reduced sialic acid content of Fc-fusion protein caused by hyperosmolar conditions [PMID: 28266015].
-   Reduced mRNA expression of beta4GalT2 and beta4GalT4 were found in B cells in mice with lineage-restricted deletion of the gene encoding MAD homologue 4 (Smad4) in T cells [PMID: 24223846].
