
-   NPR3: Atrial natriuretic peptide receptor 3; Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity. [[https://string-db.org/newstring_cgi/show_edge_details.pl?identifiers=9606.ENSP00000365663 9606.ENSP00000265074](https://string-db.org/newstring_cgi/show_edge_details.pl?identifiers=9606.ENSP00000365663%0D9606.ENSP00000265074)]
-   NPR1: Atrial natriuretic peptide receptor 1; Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand. [[https://string-db.org/newstring_cgi/show_edge_details.pl?identifiers=9606.ENSP00000365663 9606.ENSP00000357669](https://string-db.org/newstring_cgi/show_edge_details.pl?identifiers=9606.ENSP00000365663%0D9606.ENSP00000357669)]
-   NPR2: Atrial natriuretic peptide receptor 2; Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth. [[https://string-db.org/newstring_cgi/show_edge_details.pl?identifiers=9606.ENSP00000365663 9606.ENSP00000341083](https://string-db.org/newstring_cgi/show_edge_details.pl?identifiers=9606.ENSP00000365663%0D9606.ENSP00000341083)]
-   IDE: Insulin-degrading enzyme; Plays a role in the cellular breakdown of insulin, APP peptides, IAPP peptides, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. [[https://string-db.org/newstring_cgi/show_edge_details.pl?identifiers=9606.ENSP00000365663 9606.ENSP00000265986](https://string-db.org/newstring_cgi/show_edge_details.pl?identifiers=9606.ENSP00000365663%0D9606.ENSP00000265986)]
-   MME: Neprilysin; Thermolysin-like specificity but is almost confined to acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. [[https://string-db.org/newstring_cgi/show_edge_details.pl?identifiers=9606.ENSP00000365663 9606.ENSP00000418525](https://string-db.org/newstring_cgi/show_edge_details.pl?identifiers=9606.ENSP00000365663%0D9606.ENSP00000418525)]
-   dHAND interacts with MEF2C to form protein complex and bind A/T sequence in promoter of ANP [PMID: 15486975].
-   MZF1 binds to the -318 bp~-452 bp region of the NPPA promoter as tested by chromatin immunoprecipitation and dual luciferase assay [PMID: 34616853].
