
-   TRB3 expression is induced in liver under fasting conditions, and TRB3 disrupts insulin signaling by binding directly to Akt and blocking activation of the kinase. Amounts of TRB3 RNA and protein were increased in livers of db/db diabetic mice compared with those in wild-type mice. Hepatic overexpression of TRB3 in amounts comparable to those in db/db mice promoted hyperglycemia and glucose intolerance [PMID: 12791994].
-   TRIB3 mRNA expression was found to be upregulated in hepatocellular carcinoma (HCC) tissue samples. Knockdown of TRIB3 suppressed tumorigenesis in a xenograft model of HCC [PMID: 32716348]. TRIB3 was significantly overexpressed in advanced grade hepatocellular carcinoma (HCC) tissues and was closely correlated with poor prognosis [PMID: 34532390].
-   In mice treated with a high dose of CCl4, an established model for hepatotoxicity, Trib3 mRNA was upregulated in the pericentral zone of hepatocytes [PMID: 24748426].
-   Trib3 mRNA and protein expression were upregulated by homocysteine in primary cultured hepatocytes, correlating with inhibited hepatocyte proliferation [PMID: 23349842].
