
-   APOA4-AS directly interacts with mRNA stabilizing protein HuR and stabilizes APOA4 mRNA. Deletion of HuR dramatically reduces both APOA4-AS and APOA4 transcripts. The data shows that an anti-sense lncRNA (APOA4-AS), which is co-expressed with APOA4, concordantly and specifically regulates APOA4 expression both in vitro and in vivo with the involvement of HuR [PMID: 27131369].
-   CREBH is an endoplasmic reticulum (ER) anchored transcription factor that is highly expressed in the liver and small intestine and implicated in nutrient metabolism and proinflammatory response. CREBH directly controls Apoa4 expression through two tandem CREBH binding sites (5'-CCACGTTG-3') located on the promoter, which are conserved between human and mouse [PMID: 24598141].
-   Fibroblast growth factor 19 (FGF19) is a gut-derived peptide hormone that is produced following activation of Farnesoid X Receptor (FXR) where Apo4 serves as a target for FGF19 [PMID: 28178326].
-   In Caco-2 intestinal epithelial cells, E-cadherin controls enterocyte-specific expression of genes, such as triggering the transcriptional activation of the apoA-IV promoter, through the control of hepatic nuclear factor 4alpha nuclear abundance [PMID: 16338932].
-   C/EBPbeta is a key transcription factor for temporally regulating APOE4 gene expression and preferentially mediates ApoE4 expression in Alzheimer's disease [PMID: 33339957].
