
-   Nuclear receptor retinoic X receptor-alpha:retinoic acid receptor-alpha (RXRalpha:RARalpha) acts as a repressor of MRP3 activation in luciferase reporter assays. Transcription factor Sp1 was found to stimulate MRP3 promoter activity and that additions of RXRalpha:RARalpha abrogated this activation in a dose-dependent manner [PMID: 17272513].
-   Novel CCAAT/enhancer binding protein beta (C/EBPbeta) and heat shock factor 4 (HSF4) transcription binding sites were identified on the rat mrp3 promoter. Deletion of the HSF4 element significantly increased transcriptional activity of the mrp3 gene when exposed to TNF-alpha [PMID: 17196161].
-   As a transcription factor, activated Nrf2 heterodimerizes with small Maf or Jun proteins and binds to the antioxidant response element (ARE) located in the promoter region of Nrf2 target genes. ABCC3/MRP3 is one of the target genes activated by NRF2 in response to oxidative stress and exposure to electrophilic compounds [PMID: 23109674].
-   Ligand activated Pregnane X receptor competes for coactivators of the hepatocyte nuclear factor 4 alpha transcription factor which leads to the down-regulation of MRP3 [PMID: 27932985].
