
-   P53: p53 up-regulated CROT transcription allowing cells to be more efficiently utilizing stored very long-chain fatty acids to survive nutrient depletion stresses. CROT is a p53 target that promotes oxidative metabolism and cell survival following nutrient starvation [PMID: 37307919].
-   Expression of miR-33 from an SREBP2 intron inhibits the mRNA expression of the fatty acid oxidation-regulatory genes CROT in chicken liver [PMID: 30698464].
-   Niclosamide markedly inhibited calcification along with reduced CROT mRNA expression. Niclosamide improved features of fatty liver, including decreased cholesterol levels along with decreased Crot expression in LDL receptor (Ldlr)-deficient mice fed a high fat diet (a model of induced atherosclerosis and cardiovascular calcification) [PMID: 35127876].
