
-   Early growth response factor 1 (Egr-1), which is induced by hypoxia, can activate the basal transcriptional activity of the EGFR promoter and enhance endogenous EGFR expression. [PMID: 11830539].
-   EGR1 is expressed in numerous cell types and is activated by a wide array of stimuli such as growth factors, cytokines, mitogens, apoptosis, oxygen deprivation, oxidative stress, viral infections, and tissue injury [PMID: 2107209, PMID: 9685645, PMID: 15788231, PMID: 36338037, PMID: 33783681].
-   Acute administration of METH causes activation of immediate-early genes (IEGs) such as Zif268 (Egr-1) mRNA in rodent brains. Superoxide radicals were identified as mediators of the effects of methamphetamine on Egr-1 in the brain [PMID: 9685645].
-   As a bivalent regulator of EGR1, Elk-1 can induce transcription of EGR1 through recruitment of histone acetyltransferases, such as p300/CBP (Li et al., 2003), or function to repress EGR1 transcription via recruitment of histone deacetylases, such as mSin3A-HDAC [PMID: 12514134, PMID: 11283259].
