
-   Glucocorticoid receptor (GR), a ligand-dependent transcription factor, regulate hormone-dependent gene activation of metallothioneine-2A (MT2A). This activation can be inhibited by curcumin, a compound known to inhibit GR-mediated transcription [PMID: 21127044].
-   MT2A gene expression is regulated by heavy metals, which is mediated by a zinc-sensitive inhibitor that interacts with a constitutively active transcription factor, MTF-1 [PMID: 8108390, PMID: 25760317].
-   PZ120, a zinc finger protein, has been revealed to repress the transcription of the MT-2A promoter [PMID: 9858591].
