
-   Expression of LCN-2 was induced by TNFalpha in astrocytes. The inductive effects of TNFalpha on LCN-2 mRNA expression is dependent on the NF-kappaB pathway [PMID: 36781380, PMID: 24391115].
-   IFNgamma causes LCN-2 expression and secretion. The ability of IFNgamma to induce LCN-2 mRNA expression is dependent on STAT1 pathway, as demonstrated by siRNA-mediated knockdown of STAT1 which resulted in attenuation in the induction effect of IFNgamma on LCN-2 [PMID: 24391115].
-   IL-6 stimulation induced LCN2 production in hepatocytes through the STAT3 signaling pathway, evidenced by STAT3's recruitment to the Lcn2 gene promoter, as demonstrated by chromatin immunoprecipitation assay [PMID: 25234944].
-   LCN2 mRNA expression was markedly increased in macrophages stimulated by TLR4 (LS), TLR2/1 (Pam3CSK4) and TLR5 (flagellin) ligands [PMID: 15531878].
