
-   Protein Accession: Q99618
-   Size: 268 amino acids
-   Molecular mass: 28998 Da
-   Domain: The KEN box is required for the association with the APC/C-Cdh1 complex [[https://www.genecards.org/cgi-bin/carddisp.pl?gene=CDCA3&keywords=CDCA3#domains_families](https://www.genecards.org/cgi-bin/carddisp.pl?gene=CDCA3&keywords=CDCA3#domains_families)].
-   Family: Cell division cycle associated (CDCA) gene family [PMID: 32913466].
-   F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase (By similarity) [[https://www.proteinatlas.org/ENSG00000111665-CDCA3](https://www.proteinatlas.org/ENSG00000111665-CDCA3)].
-   Skp1 (S-phase kinase-associated protein 1) is a core component of the SCF (Skp1-Cullin 1-F-box) E3 ubiquitin ligase complex necessary for protein degradation by the 26S proteasomal pathway [PMID: 26575697]. Tome-1 has an F box motif and associates with Cul-1 and Skp-1, with evidence showing that the F box motif is necessary for Tome-1 to interact with Skp-1 [PMID: 12679038].
