
-   Protein Accession: Q86SG2
-   Size: 305 amino acids
-   Molecular mass: 34297 Da
-   Domains: Ankyrin_rpt, Ankyrin_rpt-contain_sf
-   Family: a member of the muscle ankyrin repeat proteins (MARPs) family
-   DARP contains a single coiled-coil domain at the N-terminus, followed by several conserved ankyrin-repeats towards the C-terminus. DARP contain potential coiled-coil dimerization motifs within their unique aminoterminal domains that mediate the formation of homo-dimers [PMID: 16450059]. DARP contains putative nuclear localization signals and four tandem ankyrin-like repeats [PMID: 12456686]. The C-terminus of MARPs contains a series of ankyrin repeats, whose best-characterized function is to bind to the N2A region of the giant sarcomeric protein titin [PMID: 14583192]. Binding of MARP to titin also affects its PKA mediated phosphorylation. MARPs themselves are phosphorylated by PKA and PKC, potentially altering their structure or function. The deregulation of ANKRD23 is associated with many cardiac and skeletal myopathies [[*PMID: 25125175,*](https://www.ncbi.nlm.nih.gov/pubmed/25125175) PMID: 20515317].
