
-   The expression of Cdkn1a gene was diminished in the liver of MOD-1 mice, which lack the ME1 protein, compared to wild type mice. The diminished expression of Cdkn1a in MOD-1 mice was associated with reduced hepatosteatosis [PMID: 37047583].
-   CDKN1A gene expression was upregulated in mice on a high-fat diet. The upregulation was attenuated if diet was supplemented by lingonberry [PMID: 34835949].
-   p21 mRNA expression was induced in rat liver by administration of phenobarbital. mRNA level elevation was followed by a marked elevation of proliferating cell nuclear antigen (PCNA) and apoptotic indices [PMID: 11872643].
-   The p21 and caspase-3 mRNA expressions were significantly upregulated in the livers of rats injected with streptozotocin in the model of diabetes [PMID: 36818894].
-   Expression of p21 was elevated in a biphasic manner in a rat model of liver regeneration by a partial hepatectomy. The enhanced expression was observed during G1 phase and following S phase. Hepatic p21 mRNA was also induced by dietary protein deprivation in normal mice [PMID: 9049198].
-   The Cdkn1a gene was found to be one of the most upregulated in proliferating biliary epithelial cells (BECs) after acute bile duct injury [PMID: 33724957].
-   The expression of Cdkn1a was found to be higher in nonalcoholic steatohepatitis (NASH) rats than in normal rats. After treatment with Shenqi pill (SQP), the expression of Cdkn1a decreased [PMID: 35733920].
