
-   The human arginase-I promoter region shows multiple STAT3-binding elements with evidence of phosphorylated STAT3 binding to multiple sites in the arginase-I promoter. In myeloid-derived suppressor cells (MDSC) from head and neck squamous cell carcinoma (HNSCC) patients, activated STAT3 appears to regulate the suppressive function of arginase-I [PMID: 23454751].
-   In THP-1 derived macrophages, OSM enhances the expression of HIF1-alpha while also increasing HIF1-alpha localization to the nucleus where it acts as a transcription factor regulating expression of genes like ARG-1 [PMID: 29246543].
-   Gcn4p, a transcription factor induced by amino acid starvation, activates the transcription of the arginine biosynthetic gene ARG1. Cyc8p and Tup1p are recruited to the ARG1 promoter, consistent with a direct role for this complex in stimulating Gcn4p occupancy of the upstream activation sequence (UAS). Gcn4p also stimulates binding of Cyc8p/Tup1p at the 3' ends of these genes, raising the possibility that Cyc8p/Tup1p influences transcription elongation. Data suggests that Gcn4p may enhance its own binding to the UAS by recruiting Cyc8p/Tup1p [PMID: 19233144, PMID: 16314536].
