
-   TSG101 mRNA expression was found to be significantly upregulated in glioma tissues, with higher levels correlating with poor prognosis [PMID: 33411238].
-   In both human post-mortem tissue and mouse models humanized for apolipoprotein E, it was found that the expression of the apolipoprotein E4 allele, whether homozygous or heterozygous, leads to a reduction in brain exosome levels compared to the risk-neutral epsilon 3 allele. This reduction is associated with decreased expression of tumor susceptibility gene 101 (TSG101) mRNA and protein, indicating a downregulation of exosome biosynthesis and release due to the apolipoprotein E4 genotype [PMID: 30496349].
