
-   The CD44 rs13347C>T and rs115214213T>C polymorphisms of CD44 3'UTR which were found to be associated with nasopharyngeal carcinoma, may affect cancer development by improving CD44 expression among the Chinese Han population [PMID: 25268088].
-   Tumors overexpressing CD44v isoforms such as CD44v6, CD44v9, and CD44v10 have a poor prognosis [PMID: 33505471].
-   The soluble fragment of CD44 (sCD44), detected in serum of healthy humans, increases its concentration in inflammatory diseases such as systemic sclerosis, chronic periodontitis, aggressive periodontitis, endometriosis, pulmonary tuberculosis, sarcoidosis, open-angle glaucoma, and pouchitis [PMID: 33505471].
-   In human colorectal neoplasia CD44 variant proteins, including homologues of those which confer metastatic ability to rat tumors, were found on all invasive carcinomas and carcinoma metastases [PMID: 8416989]
-   In thyroid cancer cells, CD44 facilitates the recruitment of cyclin D1 and thus cell proliferation [PMID: 22271686].
-   The expression levels of CD44v6 were shown to be significantly higher in ovarian cancer tissues, as compared with adjacent normal tissues. Furthermore, the upregulated expression levels of CD44v6 were correlated with disease recurrence and poor survival in patients. In addition, the expression of CD44v6 was positively correlated with the expression levels of beta-catenin and tumor growth factor-beta [PMID: 25573529].
