
-   Protein Accession: Q15063
-   Size: 836 amino acids
-   Molecular mass: 93314 Da
-   Domains: EMI_domain, FAS1_dom_sf, FAS1_domain, TGFBI/POSTN
-   Family: None
-   OSF-2 has a typical signal sequence, followed by a cysteine-rich domain, a fourfold repeated domain and a C-terminal domain. The protein lacks a typical transmembrane region. The fourfold repeated domain of OSF-2 shows homology with the insect protein fasciclin I [PMID: 8363580]. The four internal repeat regions of periostin share homology with an axon guidance protein FAS1, containing sequences that allow binding of integrins and glycosaminoglycans in vivo [PMID: 2335571]. At the N-terminus, periostin has an EMI domain, which is a small cysteine-rich module of ~75 amino acids. The EMI domain is associated with other domains (such as C1q, laminin-type EGF-like, FN3, WAP, ZP, or FAS1) and binds to fibronectin [PMID: 11068053, PMID: 27234502].
