
-   Hepatic lipocyte activation increased TIMP-1 mRNA expression in freshly isolated human lipocytes, indicating that hepatic lipocytes can regulate matrix degradation in the liver, and suggest that expression of TIMP-1 by activated lipocytes may contribute to the progression of liver fibrosis [PMID: 1634616].
-   The tissue inhibitor of metalloproteinase-1 (TIMP-1) and interstitial collagenase RNA expression in explanted human liver of end-stage autoimmune chronic active hepatitis were coordinately up-regulated. TIMP-1 mRNA was present in unstimulated hepatic lipocytes in culture and up-regulated in response to tumor necrosis factor alpha stimulation [PMID: 7671571].
-   TIMP-1 and TIMP-2 expression is also upregulated in animal models of progressive fibrosis, whereas expression of collagenase is unchanged [PMID: 10371419].
