
-   Protein Accession: Q15049
-   Size: 377 amino acids
-   Molecular mass: 41141 Da
-   Domains: Membrane_MLC1
-   Blocks: Ribosomal protein S14
-   Family: MLC1 is a membrane protein with low identity to the Kv1.1 potassium channel and GlialCAM belongs to an adhesion molecule family [PMID: 29079544]. Blast sequence analysis indicates that MLC1 has no similarities with known proteins, with the exception of a very low homology with the shaker-related voltage gated potassium (K+) channel Kv1.1 alpha subunit (less than 20% amino acid identity) [PMID: 25883547, PMID: 15367490].
-   MLC1 gene encodes a 377-amino acid highly hydrophobic protein containing eight predicted transmembrane domains and short amino and carboxylic- cytoplasmic tails, and that both the N- and C-terminus face the cytoplasm [PMID: 25883547, PMID: 34847774]. Subcellular fractionations of rat astrocytes and brain tissue it was found that the MLC1 monomeric form is present only in the cytosolic fraction (mainly organelle fraction) while the dimers are associated with the membrane compartments (plasma membrane and endoplasmic reticulum membranes [PMID: 19931615]. Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx [[https://www.genecards.org/cgi-bin/carddisp.pl?gene=MLC1&keywords=Mlc1#domains_families](https://www.genecards.org/cgi-bin/carddisp.pl?gene=MLC1&keywords=Mlc1#domains_families)].
