
-   Regulator of G protein signaling 1 (RGS1) RNA expression was significantly elevated in regulatory T cells (Tregs) compared to other CD4+ T cells in two independent public scRNA-seq datasets, and increased RGS1 predicted inferior clinical outcome of hepatocellular carcinoma (HCC) patients. Multiplex immunofluorescence analysis supported that the higher expression of RGS1 in HCC Tregs in tumor tissue compared to it in adjacent tissue. Moreover, RGS1 expression in Tregs was positively correlated with the expression of marker genes of Tregs, C-X-C chemokine receptor 4 (CXCR4), and three CXCR4-dependent genes in both scRNA-seq and bulk RNA-seq data [PMID: 36938729].
-   In a rat model of alcoholic fatty liver disease (AFLD), potential target mRNAs were analyzed using the bioinformatics techniques. Integrating the rat model results with hepatic gene expression profiles assessed in patients with alcoholic hepatitis and normal livers showed that there were 12 genes including RGS1 with significant changes in these two data sets [PMID: 36030034].
-   In the differentially expressed genes, *RGS1* showed the greatest fold change in Pre_exhaust and exhausted T cells from PBMSc of three cancers, colorectal cancer (CRC), hepatocellular cancer (HCC), and nonsmall cell lung cancer (NSCLC), compared with effector T cells, and high expression of *RGS1* was also associated with poor prognosis in various cancer types examined. *RGS1* expression was higher in stages II, III, and IV vs. stage I in stomach adenocarcinoma. These results revealed that *RGS1* was likely a key tumorigenesis regulator in multiple cancers and may be associated with prognosis. RGS1 was significantly expressed more in cancer tissues than in normal liver tissues. Overall, *RGS1* was highly expressed in exhausted T cells in cancers, upregulated in tumor tissues in mRNA and protein levels, and with poor prognosis in multiple cancers, which indicated its potential key role in T-cell exhaustion (Tex) or cancer progress, and RGS1 might be an effective prognostic marker or a marker to identify Tex cells [PMID: 34956194].
