
-   GATA4 is the major activator of EPHX1 expression while HNF3 was shown to act as a co-repressor in HepG2 cells [PMID: 15465926].
-   CCAAT/enhancer-binding protein alpha (C/EBPalpha) activates transcription of the human microsomal epoxide hydrolase gene (EPHX1) through the interaction with DNA-bound NF-Y (A subunit, 189903; B subunit, 189904; C subunit, 605344) [PMID: 15150264]. Several nuclear receptors, HNF4A (600281), CAR (NR1I3, 603881), and RXR (RXRA, 180245 and RXRB, 180246, also bind to the proximal EPHX1 promoter region and regulate its expression in human hepatocytes [PMID: 23714182].
-   Insulin positively and glucagon negatively regulate EPHX1 expression in primary rat hepatocytes [PMID: 12975336, PMID: 17097148].
-   Mouse and rat EPHX1 were shown to be readily inducible by xenobiotics in several animal studies [PMID: 6408085, PMID: 1840481, PMID: 21132492].
-   The E1b promoter contributes predominantly to mEH expression. Sulforaphane (SFN) and tert-butylhydroquinone (tBHQ), two Nrf2 activators, markedly activate E1b transcription in human lung and liver cells. An activator protein 1/12-O-tetradecanoylphorbol-13-acetate interaction was identified within the HS-2 enhancer that functioned to additionally contribute to ARE-mediated induction responsiveness of the E1b promoter [PMID: 24704207].
-   Sp1 and Sp3 transcription factors regulate the basal expression of human microsomal epoxide hydrolase (EPHX1) through interaction with the E1b far upstream promoter [PMID: 24315822].
