
-   HNF-1a is overexpressed in pancreatic cancer, and the transcription factor HNF-1a can promote pancreatic cancer growth and apoptosis resistance via its target gene PKLR [PMID: 32072180].
-   In human leukemic cells, FLI1 promotes leukemia in part by inducing glycolysis, implicates PKLR in erythroid differentiation, and suggests that targeting glycolysis may be an attractive therapeutic strategy for cancers driven by FLI1 overexpression [PMID: 36586017].
-   Overexpression of NQO1 and PKLR in human breast cancer tissues was related to lymph node (LN) metastasis and poor prognosis [PMID: 30954648].
-   Pyruvate kinase (PK) deficiency due to mutations of the PKLR gene is a common cause of hereditary nonspherocytic hemolytic anemia [PMID: 8664896].
