
-   Egr2 was identified as a modifier of tissue fibrosis. RNA silencing of Egr2 resulting in reduce fibrogenic gene expression, reduced Col1a1 mRNA levels and collagen accumulation in the liver [PMID: 28624207].
-   NFAT2 overexpression suppresses the malignancy of hepatocellular carcinoma through inducing Egr2 expression [PMID: 33023539].
-   EGR2 mRNA expressions of were significantly increased after infection with Toxoplasma gondii, especially high in the spleen and liver in different mouse strains (C57BL/6 and BALB/c mice) [PMID: 22451728].
-   The expression of EGR2 was distinctly decreased in hepatocellular carcinoma (HCC) specimens compared with nontumor specimens. EGR2 shows a negative association with methylation level, and its expression, along with EGR1 and EGR3, is related to progression-free survival in patients with HCC. The expressions of EGR genes, including EGR2, are positively correlated with levels of various immune cells, suggesting a link with the immune response in HCC [PMID: 36046377].
