
-   The orphan nuclear receptor that is activated by xenobiotics is the constitutive androstane receptor (CAR), which induces Mrp2 and Mrp3 (Abcc3). The CAR is an important "xenosensor" that mediates drug-induced activation of the detoxifying transport and enzyme systems in liver and intestine [PMID: 14705863]
-   MRP3 is one of the transporters which is involved in transport of drugs in the blood-placental barrier, in turn, affecting drug distribution in fetus [PMID: 31571173].
