
-   Protein Accession: Q96EH8
-   Size: 262 amino acids
-   Molecular mass: 28789 Da
-   Domains: Znf_RING/FYVE/PHD, Znf_RING, B30.2/SPRY_sf, Neuralized, NHR_dom
-   Family: Ring finger proteins
-   E3 ubiquitin-protein ligase that plays a role in various biological processes such as lung development or innate immunity [PMID: 30111563]. NEURL3 promotes innate antiviral response through catalyzing K63-linked ubiquitination of IRF7 [PMID: 35792897]. Inhibits hepatitis C virus assembly by directly binding to viral E1 envelope glycoprotein to disrupt its interaction with E2 [PMID: 30111563].
-   The full-length LINCR has RING domain-dependent ubiquitin E3 ligase activity. Polyubiquitinated products were efficiently produced by LINCR in the presence of UbcH6 [PMID: 15936721].
-   Neurl3 is a single enrichment marker not only for the entire ontogeny of hematopoietic stem cells (HSCs) but also for yolk sac hemogenic endothelial cells (HECs) [PMID: 37230320].
