
-   CROT is significantly downregulated in human hepatoma cells overexpressing AR (androgen receptor). AR may serve a role in hepatocarcinogenesis via the regulation of hepatocellular fatty acid metabolism [PMID: 28599448].
-   An overexpression of CROT in hepatic cells induced a decrease in MCFA and VLCFA levels. These changes are accompanied by an increase in the level of mRNA encoding enzymes of the peroxisomal beta oxidation. Conversely, the knock down of CROT gene had the opposite effect. These results suggest that CROT activity, by controlling the peroxisomal amount of medium chain acyls, may control the peroxisomal oxidative pathway and induce alteration in fatty acid metabolism [PMID: 21619872].
-   The relative mRNA and protein abundances of CROT, the target gene of miR-33, were significantly lower in goose fatty liver than those in goose normal liver [PMID: 34935255].
