
-   Msr1 expression was increased in cortical and subcortical brain tissue of 3xTg-AD mice (an Alzheimer's disease model) following treatment with the selective somatostatin receptor subtype-4 (SSTR4) agonist NNC 26-9100. The Msr1 upregulation support a state of microglia associated Abeta phagocytosis [PMID: 31630317]. SR-A is upregulated in a subset of reactive microglia in lesions of ischemia and in microglia associated with amyloid deposits in brains of patients with Alzheimer's disease (AD) [PMID: 8579103, PMID: 9588184].
-   Adeno-associated virus (AAV)-mediated gene transfer of a secreted decoy human macrophage scavenger receptor (sMSR, that consists of the bovine growth hormone signal sequence and the human MSR A I extracellular domains) reduces atherosclerotic lesion formation in LDL receptor knockout mice [PMID: 14664792].
