
**NCBI Gene Summary**: The protein encoded by this gene belongs to the Rho family of the small GTPase superfamily. It contains a GTPase domain, a proline-rich region, a tandem of 2 BTB (broad complex, tramtrack, and bric-a-brac) domains, and a conserved C-terminal region. The protein plays a role in small GTPase-mediated signal transduction and the organization of the actin filament system. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]

**GeneCards Summary**: RHOBTB1 (Rho Related BTB Domain Containing 1) is a Protein Coding gene. Diseases associated with RHOBTB1 include Ascaridiasis and Toxic Megacolon. Among its related pathways are Signaling by Rho GTPases and RHOBTB GTPase Cycle. Gene Ontology (GO) annotations related to this gene include GTP binding. An important paralog of this gene is RHOBTB2.
