
-   Aging is associated with decreased numbers of cortical microglia and upregulation of Lilrb4 gene expression in cortical microglia in mice [PMID: 29494550].
-   Microglia subjected to chronic hTDP-43 overexpression demonstrated strong upregulation of Lilrb4 in the cortex and spinal cord in rNLS8 mice (a mouse model of amyotrophic lateral sclerosis) during late disease and recovery [PMID: 34412701].
-   Upregulation of LILRB4 expression in the brain was observed in microglia of aged mice as well as surrounding the plaques in a mouse model of Alzheimer's disease, and its expression was associated with an immune suppressive/tolerizing function [PMID: 29494550, PMID: 29196460, PMID: 27425031].
