
-   Low Egr-1 gene expression was associated with a poor prognosis in patients with colon cancer. Overexpression of Egr-1 inhibited colon cancer cell proliferation, migration, and invasion [PMID: 34165179].
-   The expression of EGR1 was elevated in human intestinal epithelial under the toxic condition induced by the food additive carrageenan (CGN). CGN has been shown to induce intestinal inflammation, ulcerative colitis-like symptoms, or neoplasm in the gut epithelia in animal models, which are also clinical features of human inflammatory bowel disease [PMID: 22561171].
-   Binding of Egr-1 to the GC box region of the mPGES-1 promoter was enhanced by treatment with TNF-alpha in human colonocytes. Increased Egr-1 expression and binding activity were also detected in inflamed mucosa from IBD patients [[PMID: 14722058](https://www.ncbi.nlm.nih.gov/pubmed/14722058)].
