
-   Treatment of primary multinucleated mature murine osteoclasts prepared from bone marrow with the histone deacetylase inhibitor trichostatin A led to apoptosis and upregulation of CDKN1A [PMID: 17464183].
-   Exposure to benzene lead to a a significant increase in p21 mRNA expression in bone marrow of mice. The increase in expression was not observed for mice lacking microsomal epoxide hydrolase (mEH-/-) [PMID: 12655032]. The increase in p21 expression was dependent on p53 [PMID: 11896287].
