
-   Excess macrophage elastase MMP-12 is a major driver of chronic obstructive pulmonary disease. TRPML3 represents a key regulator of MMP-12 clearance by alveolar macrophages, thus neutralizing harmful MMP-12 in the lung. [PMID: 35031603]
-   IL-17 induces the expression of inflammatory cytokines and matrix degrading proteinases MMP-9 and MMP-12. [PMID: 21647421] Mice lacking either IL-17 receptor A (IL-17RA) or MMP-12 did not develop emphysema after a prolonged cigarette smoke exposure. [PMID: 21647421, PMID: 9302297]
-   ADAM-10 regulates MMP-12 during lipopolysaccharide-Induced inflammatory response in macrophages. [PMID: 36157882]
-   The serine proteinases plasmin and thrombin regulate MMP-12 activity through regulating its release via protease-activated receptor 1(PAR-1) and extracellular enzyme activation. . [PMID: 10993890]
-   Fucosyltransferase IV ((FUT4)) up-regulates expression of MMP-12 via a MAPK-NF-kappaB-dependent mechanism. [PMID: 22799384]
-   Suppressor of cytokine signaling 3 (SOCS3) expressed in M2 macrophages is involved in the attenuation and/or resolution of contact hypersensitivity (CHS), presumably by suppressing MMP-12 production. [PMID: 27015453]
-   Transforming growth factor (TGF)-beta1 is a potent stimulator of Bax, Bid, and MMP-12. [PMID: 17209037]
