
-   GPx2 promoter contains electrophile responsive element which is stimulated by Nrf2 activators such as sulforaphane (SFN), curcumin, and t-butyl hydroquinone via electrophilic thiol modification of Keap1 in the Nrf2/Keap1 system [PMID: 15923610].
-   GPx2 was identified as a target of Wnt pathway. The GPx2 promoter contains five putative beta-catenin/TCF binding sites. Colocalization of the Wnt pathway and GPx2, as well as the regulation of GPx2 via Wnt signals, point to a role of GPx2 in the continuous self-renewal of intestinal epithelium [PMID: 17937616, PMID: 22758632].
-   GPX2 is upregulated by DeltaNp63 (a transcription factor highly expressed in undifferentiated cells) through a unique responsive element in the GPX2 gene promoter, which can be activated and bound specifically by DeltaNp63 but not by p53. Upregulation of GPx2 by DeltaNp63 led to an inhibition of oxidation-induced apoptosis [PMID: 16446369].
-   Stability of GPX2 mRNA is regulated by Se availability through a selenocysteine-selenocysteine-inserting sequence (SECIS) in the 3'-untranslated region of mRNA. SECIS is recognized by a SECIS-binding protein 2, which is essential for selenocysteine incorporation [PMID: 25692238].
-   Expression of GPX2 is induced after supplementation of retinoic acid into the culture media due to activation of retinoic acid response elements in the promoter region of GPX2 [PMID: 10498757].
-   The lncRNA NMRAL2P is associated with oxidative stress in head and neck tumors. NMRAL2P promotes the transcription of GPX2 by binding to transcription factor Nrf2 [PMID: 37810778].
-   Yes-associated protein (YAP) activation led to excessive accumulation of reactive oxygen species (ROS) by downregulating the antioxidant enzyme GPX2 in a manner related to p63 blockade. In patient-derived xenograft models, digitoxin treatment efficiently inhibited lung SCC progression in correlation with reduced expression of YAP. [PMID: 28916653]
