
-   Gli1 and IFNalpha: slfn4 gene expression is regulated by both Hedgehog (HH) signaling (Gli1) and the inducible inflammatory signal (interferon-alpha). Slfn4 in immune cells correlates with metaplastic changes in Helicobacter-infected mice [PMID: 28275687].
-   LPS, Poly(I:C) and CSF-1: Slfn4 mRNA levels were observed to be up-regulated during macrophage activation by TLR4 agonist lipopolysaccharide (LPS) and the TLR3 agonist Poly(I:C). *Slfn4* mRNA levels were repressed during macrophage colony-stimulating factor (CSF-1)-mediated differentiation of bone marrow progenitors into mouse bone marrow-derived macrophages (BMM) [PMID: 21249125].
-   Schlafen 3 mRNA was induced by cyclic strain in rat intestinal epithelial cells (IEC-6). The induction of Schlafen 3 or its human homologs may modulate intestinal epithelial differentiation and preserve the gut mucosa during normal gut function [PMID: 20299602].
