
-   GSTM1 mRNA and protein down-regulation may partially account for ROS-mediated oxidative damage and hepatocellular carcinoma (HCC) carcinogenesis. GSTM1 also regulates tumor progression by disrupting the ROS-TP53 axis in HCC cells [PMID: 31605953].
-   Genetic polymorphism and null genotype of GSTM1 was involved in the pathogenesis of various liver diseases, including non-alcoholic fatty liver disease [PMID: 18492019], hepatitis and liver alcoholic cirrhosis [PMID: 19157724, PMID: 8947308, PMID: 24593909].
