
-   EVI1 is a nuclear zinc finger protein which participates in acute myeloid leukaemia progression. Evi1 represses transcription of CA-3 gene expression, leading to increased sensitivity to hydrogen peroxide-induced apoptosis in Rat1 cells. Restoring CA-3 levels in Evi1-expressing cells reverses this increased sensitivity, underscoring the protective role of CA-3 against oxidative stress and its potential in treating EVI1-overexpressing tumors.[PMID: 20015077].
