
-   Chronic HFD induced sustained hepatic steatosis and inflammatory injury, with increased inflammatory cytokines, galectin-3 (Gal-3) and TLR4 expression [PMID: 36402251].
-   Expression of Gal-3 increased when exposed to the apoptosis inducer staurosporine. Estradiol (E2) and progesterone (P4) up-regulated Gal-3 expression, which in turn decreased the apoptotic rate of endometrial cells [PMID: 22674388].
-   Galectin-3 cleavage alters bone remodeling and outcomes in breast and prostate cancer metastasis [PMID: 26837763]. Gal-3 cleavage is performed by matrix metalloproteinases (MMPs) [PMID: 20162566] and PSA [PMID: 20672323]. Cleavage of galectin-3 by matrix metalloproteases induces angiogenesis in breast cancer [PMID: 20162566].
-   Lgals3 expression is upregulated as a feature of alternative macrophage activation and is stimulated by IL-4, whereas it is inhibited by classical macrophage activation with LPS. Galectin-3 binds to CD98 which promotes alternative macrophage activation through PI3K activation [PMID: 18250477].
