
-   ALY is a context-dependent coactivator of LEF-1 and AML-1, is required for TCR alpha enhancer function [PMID: 9119228]. in addition to their activity as transcriptional activators, AML1 and LEF-1 can act, through recruitment of the corepressor TLE1, as transcriptional repressors in TCR regulation and Wnt/Wg signaling [PMID: 9751710].
-   The histone methyltransferase SUV39H1 interacts with AML1 and abrogates AML1 transactivity. The interaction of AML1 with SUV39H1 requires the N-terminus of AML1 where the Runt domain is located. [PMID: 12917624].
-   PITHD1 was an activator of internal ribosomal entry site (IRES) and enhanced RUNX1 expression that subsequently promoted megakaryocyte differentiation [PMID: 25134913].
-   miR-215 promotes malignant progression of gastric cancer by targeting RUNX1 [PMID: 26716895].
-   Cyclin D3 negatively regulates the transactivation activity of AML1 in a dose-dependent manner by competing with CBFbeta for AML1 association, leading to a decreased binding affinity of AML1 for its target DNA sequence. Thus, direct association of cyclin D3 with AML1 functions as a putative feedback mechanism to regulate cell cycle progression and differentiation [PMID: 16287839].
