
-   C/EBPdelta expression were increased in muscles of chronic kidney disease (CKD) patients. Using CCAAT/enhancer-binding protein delta (C/EBPdelta) KO mice and C2C12 myotubes with knockdown of C/EBPdelta or myostatin, a study showed that p-Stat3 initiates muscle wasting via C/EBPdelta, stimulating myostatin, a negative muscle growth regulator in muscles of chronic kidney disease (CKD) patients [PMID: 24011072].
-   The gene expression of CEBPD was found to be increased during starvation. This increase was associated with the induction of the ubiquitin-proteasome system and a decrease in myofibers in FOXO1-activated myotubes. Increased C/EBPdelta expression was associated with muscle atrophy [PMID: 35061305].
