
-   Adam10^DeltaLyz2^ mice exhibited a significantly higher mortality rate, stronger lung inflammation, and a higher virus titer in the lungs than control mice. CD11b^+^Ly6G^\\-^F4/80^+^ myeloid cells, which had an inflammatory monocyte/macrophage-like phenotype, were significantly increased in the lungs of Adam10^DeltaLyz2^ mice. After influenza virus infection, CD11b^+^Ly6G^\\-^F4/80^+^ lung cells exhibited significantly higher arginase-1 expression levels in Adam10^DeltaLyz2^ mice than in control mice, whereas an arginase-1 inhibitor improved the prognosis of Adam10^DeltaLyz2^ mice [PMID: 34523355].
-   Compared with the control rats, there were a significant decline in lung function, a marked inflammatory infiltration and pulmonary parenchymal remodeling in a rat model of chronic obstructive pulmonary disease (COPD). In lung tissue of COPD rats, Arg-1 expression was significantly decreased while H~2~ treatment improved the lung function and the parenchymal inflammation, up-regulated expression of Arg-1 in lung tissue [PMID: 34282696].
-   Compared with the control group, Arg1 mRNA and protein expression levels were significantly increased in a model of severe pneumonia in rats [PMID: 37735894].
