
-   Expression of Carbonic Anhydrase III is hypoxia-responsive and confers protection from oxidative stress-induced cell death [PMID: 29559661].
-   CAIII is highly expressed in osteocytes, is regulated by parathyroid hormone (PTH) both in vitro and in vivo [PMID: 28928248].
-   CaIII transcripts were repressed by 92-97% by Evi1 expression, which was accompanied by a similar reduction in caIII protein and increased sensitivity of Rat1 fibroblasts to H(2)O(2)-induced apoptosis [PMID: 20015077].
-   CAIII is expressed as one of the major Zn-binding proteins in the livers of male rats in an age-dependent manner. Castration of male rats resulted in a 75-90% reduction in CAIII [PMID: 10682938]. Androgen-linked control of carbonic anhydrase III expression occurs in rat perivenous hepatocytes [PMID: 11817565].
-   Squalene epoxidase (SQLE) is highly up-regulated in human nonalcoholic steatohepatitis (NASH) and mouse models of NASH. SQLE directly bound to CA3, which induced sterol regulatory element-binding protein 1C activation, acetyl-CoA carboxylase, fatty acid synthase, and stearoyl-CoA desaturase1 expression and de novo hepatic lipogenesis [PMID: 33647280].
