
-   scRNA-seq was used to study the dynamics of mouse liver regeneration after acute acetaminophen (APAP) intoxication. A subset of hepatocytes located at the regenerating front transiently upregulate fetal-specific genes, including Afp and Cdh17, as they reprogram to a pericentral state [PMID: 35659879].
-   Alternative mRNA splicing isoform of CDH17 was reported in hepatocellular carcinoma patient samples. The isoform skips exon 7 which leads to open reading frame shift. The mRNA isoform is associated with shorter overall survival time [PMID: 15701831].
-   In metastatic liver and peritoneal tissues from patients with colorectal adenocarcinoma, the average microarray expression levels of LI-cadherin, ALCAM, CD2, and CD14 were significantly higher in both metastatic sites. The results demonstrate that liver and peritoneal metastases of lower gastrointestinal adenocarcinoma have distinct gene expression pattern [PMID: 17899288].
