
-   Transcription factors (TFs) with ChIP-seq peaks which intersect with the candidate cis-regulatory elements (cCRE) of HAVCR1 in SCREEN Registry include JUN, EP300, JUNB, FOSL2 and POLR2A [[https://screen.encodeproject.org/search/?q=havcr1&assembly=GRCh38&uuid=19d839c3-d90c-4396-a9e4-c1699fe24be2#tf](https://screen.encodeproject.org/search/?q=havcr1&assembly=GRCh38&uuid=19d839c3-d90c-4396-a9e4-c1699fe24be2#tf)]
-   EP300: This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [[https://www.factorbook.org/tf/human/EP300/function](https://www.factorbook.org/tf/human/EP300/function)]
-   JUN: This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3' [PMID: 10995748, PMID: 22083952].
-   JUNB: Transcription factor jun-B is a protein that in humans is encoded by the JUNB gene. Transcription factor jun-B is a transcription factor involved in regulating gene activity following the primary growth factor response. It binds to the DNA sequence 5'-TGA[CG]TCA-3'. [[https://www.factorbook.org/tf/human/JUNB/function](https://www.factorbook.org/tf/human/JUNB/function)]
-   FOSL2: The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. [[https://www.factorbook.org/tf/human/FOSL2/function](https://www.factorbook.org/tf/human/FOSL2/function)]
-   POLR2A (RNA polymerase II subunit A): This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. [[https://www.factorbook.org/tf/mouse/POLR2A/function](https://www.factorbook.org/tf/mouse/POLR2A/function)]
