
-   Protein Accession: Q13454
-   Size: 348 amino acids
-   Molecular mass: 39676 Da
-   Domains: Thioredoxin-like_sf, OligosaccharylTrfase_OST3/OST6
-   Blocks: OST3/OST6
-   Family: Belongs to the OST3/OST6 family.
-   TUSC3 encode a subunit of the endoplasmic reticulum-bound oligosaccharyltransferase complex that catalyzes a pivotal step in the protein N-glycosylation process [PMID: 18452889]. N33/Tusc3 possesses a membrane-anchored N-terminal thioredoxin domain located in the ER lumen that may form transient mixed disulfide complexes with oligosaccharyl transferase (OST) substrates. N33/Tusc3 prefers peptides bearing a hydrophobic residue two residues away from the cysteine forming the mixed disulfide with N33/Tusc3. N33/Tusc3 binds different substrate peptides in opposite orientations. N33/Tusc3 may increase glycosylation efficiency for a subset of human glycoproteins by slowing glycoprotein folding [PMID: 24685145].
-   The N33 gene showed partial methylation in normal colon mucosa, which was age-related [PMID: 9850084].
-   N33 was shown as one of the nine genes overexpressed in fibroblastic mesothelial cells as compared with cells with epithelioid phenotype, suggesting its role in mesothelial differentiation [PMID: 14551161].
