
-   In the kidney, ANP stimulates diuresis and natriuresis [PMID: 2945668, PMID: 25013796].
-   ANP inhibits the production of aldosterone by actions in the adrenal glands and induces vasorelaxation of vascular smooth muscle cells [PMID: 14963664, PMID: 2933640].
-   Endothelial actions of atrial natriuretic peptide prevent pulmonary hypertension in mice [PMID: 26909880].
-   Some studies have shown a direct relaxant effect of ANP on isolated bronchi from guinea pigs and cows [PMID: 2933640, PMID: 2933640, PMID: 246640].
-   A role of ANP in human lung diseases has also been investigated, and increased levels of ANP have been reported in adult respiratory distress syndrome [PMID: 2972531] as well as in patients with chronic obstructive pulmonary disease (COPD) [PMID: 8153922, PMID: 32010874].
-   ANP also inhibits aldosterone production in the adrenal gland [PMID: 6096716].
-   In adipocytes, ANP enhanced mitochondrial respiration and the brown fat thermogenic program via a PKG-p38 mitogen-activated protein kinase (MAPK)-mediated pathway [PMID: 22307324].
-   ANP resistance is a hallmark of nephrotic syndrome [PMID: 2554049], liver cirrhosis [PMID: 9353863, PMID: 2963741].
-   Low plasma ANP levels were associated with obesity and type 2 diabetes [PMID: 22112816].
