
-   Size: 396 amino acids
-   Molecular mass: 45372 Da
-   Protein Accession: P06727
-   Family: Belongs to the apolipoprotein A1/A4/E family
-   Domains: ApoA_E
-   Apolipoproteins, including ApoA4, with amphipathic alpha helices complement Hepatitis C virus production in human non-liver cells, with differences in assembly efficiency, specific infectivity of released particles, and extracellular to intracellular infectivity ratios suggesting distinct characteristics that influence virus assembly and cell entry [PMID: 26226615].
-   ApoA-IV is present in human plasma in three distinct metabolic pools; apoA-IV associated with the triglyceride-rich lipoproteins is a precursor to the apoA-IV high density lipoprotein (HDL) and lipoprotein-free fraction (LFF) pools; apoA-IV in LFF is not a free protein and its turnover rate is faster than that of apoA-IV in HDL [PMID: 3095477].
-   Apolipoprotein AIV (apoAIV), a protein which is known to activate the enzyme lecithin: cholesterol acyltransferase, to bind to apoAI/AII receptor sites and also to promote cholesterol efflux from adipose cells, may play an important role in reverse cholesterol transport [PMID: 1935934].
-   The multiple amphipathic helical domains of apoA-IV is regarded to contribute to its function in lipid efflux, similar to apoA-I and other apolipoproteins, when interacting with human ABCAI transporter [PMID: 11162594].
-   Human apoA-IV was found to increase lipoprotein lipase (LPL) activity when combined with very low density lipoproteins (VLDL) [PMID: 2307668].
