
-   The mRNA expression of Periplakin (Ppl) was found to be upregulated in liver tissues of p21-HBx transgenic mice, which is a model for the study of hepatitis B virus encoded HBx protein-associated hepatocarcinogenesis. This upregulation was also validated in human hepatocellular carcinoma (HCC) tissues. This suggests a possible role of Ppl in the pathogenesis or progression of HCC [PMID: 17873514].
-   Ppl mRNA expression was significantly reduced in the liver of farnesoid X receptor (FXR) knockout mice (Fxr-/-) and markedly increased during cholestasis in wild-type mice. In two distinct mouse models of cholestasis induced by alpha-naphthylisothiocyanate (ANIT) treatment or bile duct-ligation (BDL) respectively, significantly increased levels of Ppl mRNA and protein were observed in the liver. Thus, hepatic accumulation of PPL was highly associated with cholestasis [PMID: 23849208].
