
-   EGR1, CYR61 and ADAMTS1 were overexpressed in gastric cancer (GC) and precancerous lesions compared with tissues from non-tumor patients. These three genes were also overexpressed in intestinal metaplasia (IM) and dysplasia (DYS), which indicated that these three genes might be potential biomarkers for early detection of gastric cancer [PMID: 19727222]. High ADAMTS1 mRNA and protein expression was found to be significantly associated with lymph node metastasis in primary gastric tumors [PMID: 23001403].
-   The Adamts-1 mRNA was included by IL-1 stimulation in the murine colon 26 adenocarcinoma cells [PMID: 8995297].
-   Adamts1 is hypermethylated in colorectal tumors. The methylation status of ADAMTS1 was investigated in 116 colorectal carcinomas and adenomas. Twenty-three of 63 (37%) adenomas and 37/52 (71%) carcinomas were hypermethylated for this gene [PMID: 17167179].
