
-   PDK4 expression was significantly downregulated in human hepatocellular carcinoma (HCC). PDK4 deficiency in mouse liver results in expedited hepatocyte proliferation through E2F1-mediated increase of cyclins [PMID: 28003426].
-   PDK4 mRNA was decreased after ischemia in rat hearts but preserved with cardioplegia [PMID: 16214533].
-   Pdk4 gene expression was increased in Erectile dysfunction (ED) patients compared with controls [PMID: 34817334].
