
-   TWEAK and Fn14 were overexpressed in mouse autosomal dominant polycystic kidney disease (ADPKD) kidney cysts [PMID: 34155062].
-   As compared to controls, lupus nephritis (LN) patients had higher mRNA expression of TWEAK and Fn14 in the kidney [PMID: 21303425].
-   Fn14 mRNA expression in kidney was increased in experimental acute renal failure induced by folic acid or by ischemia-reperfusion in mice [PMID: 17003819, PMID: 20927042].
-   Fn14 mRNA is upregulated in glomeruli from patients with focal segmental glomerulosclerosis and in murine models of protein overload-induced proteinuria [PMID: 23999007].
-   Gene and protein levels of CXCL1 and TNFRSF12A were significantly increased in various AKI mouse models and in patients with AKI [PMID: 38472598].
-   Fn14 gene expression increases in the kidneys of high serum IgA (HIGA) mice, a model for IgA nephropathy (IgAN), starting from 6 weeks of age, with changes in deposition patterns reflecting the progression of the disease; initial increase and later decrease in Fn14 levels suggest its involvement in early but not advanced stages of pediatric IgAN [PMID: 34597335].
-   Fn14 was found to be overexpressed in kidney cysts of a mouse model of autosomal dominant polycystic kidney disease (ADPKD) [PMID: 34155062].
-   Fn14 gene expression was increased in the kidney of a murine model for Shiga toxin-induced hemolytic-uremic syndrome (HUS)-like disease [PMID: 32433206].
