
-   Acot1 is strongly upregulated at the mRNA and protein level in rodents by fibrates. Acot1 mRNA levels were increased by 90-fold in liver by treatment with Wy-14,643, an agonist of peroxisome proliferator-activated receptor-alpha (PPAR-alpha) [PMID: 17485727].
-   Acot1 transcripts increased significantly in primary rat hepatocytes and liver after perfluorooctanoic acid (PFOA) treatment. Acot1 could serve as a sensitive indicator for PPARalpha activation after PFOA exposure in primary rat hepatocytes [PMID: 28511854, PMID: 36337235].
