
-   Hepatic nuclear factor 1alpha (HNF1alpha) and caudal-related homeobox 2 (CDX2) have binding sites at the proximal promoter region of CDH17 which can modulate the promoter activities in two hepatocellular carcinoma (HCC) cell lines (Hep3B and MHCC97L). Suppression of HNF1alpha and CDX2 expression by small interfering RNA significantly down-regulated expressions of CDH17 and its downstream target cyclin D1 and the viability of HCC cells in vitro [PMID: 20568120].
-   HOXA13 can elevate CDH17 transcription via binding to its promoter and CDH17 was suggested to be a downstream effector of HOXA13 in modulating the Wnt/beta-catenin signaling pathway in gastric cancer cells [PMID: 28387908].
