
-   In whole blood assessed by RNA sequencing revealed key regulator transcripts identified in psoriasis and cardiovascular disease (CVD) cohorts included a transcriptomic signature consisting of PIM3. The whole blood transcriptomic signature of psoriasis diagnosis and severity associated with prevalent myocardial infarction and incident major adverse cardiovascular or limb events. These data have implications for better understanding the link between psoriasis, systemic inflammation and CVD [PMID: 36924033].
-   In vivo studies have shown that when cells overexpressing Pim-3 were seeded into nude mice, 100% of the mice developed tumors under the skin [PMID: 24789328, PMID: 31882428].
