
-   Congenital hepatic fibrosis / Autosomal recessive polycystic kidney disease (CHF/ARPKD) is an inherited neonatal disease characterized by cysts, and robust pericystic fibrosis in liver and kidney. The Lamc2 gene was found to be overexpressed in PCK rats, a model for CHF/ARPKD, at postnatal day (PND) 30 and 90 [PMID: 36711494].
-   Lamc2 mRNA and protein levels were increased in the kidneys of aged animals compared with young animals, suggesting a role for Lamc2 gene dysregulation in renal aging [PMID: 29846172].
