
-   The heat-shock protein Hsp90 has been shown to be essential for the functional integrity of the telomerase complex. The telomerase activity is enhanced in melanoma and stabilizes the chromosomal integrity in proliferating cells. By analyzing microdissected human melanocytic tumors by semiquantitative PCR, the results demonstrated an overexpression of Hsp90 mRNA in malignant melanomas and in melanoma metastases as well as in melanoma cell lines when compared with melanocytic nevi. These results could be confirmed on protein level by immunohistochemistry [PMID: 15009113].
-   Skin samples from psoriatic patients showed increased mRNA expression of HSP90 in psoriatic patients as compared to healthy volunteers. The expression of HSP90 increases with the frequency of exacerbations of psoriasis [PMID: 36751545].
-   Dermal content of HSP90 in mice was increased after an exposure to an ambient temperature of 43 decrees C [PMID: 12388648]
