
-   Size: 423 amino acids
-   Molecular mass: 47651 Da
-   Protein Accession: P01011
-   Domains: Serpin_CS, Serpin_dom, Serpin_fam, Serpin_sf, Serpin_sf_1, Serpin_sf_2
-   Family: Serpin family.
-   The protein encoded by this gene is a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2 [PMID: 2404007]. The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable.
-   Serpina3n can inactivate human anti-trypsin, anti-chymotrypsin, cathepsin G, elastase, granzyme B, MMP9, and selective cysteine proteases [PMID: 31790278].
-   The single human alpha1-antichymotrypsin gene (SERPINA3) is represented by a cluster of 14 individual murine paralogs [PMID: 12659817].
