
-   miR-31a-5p promotes postnatal cardiomyocyte proliferation by targeting RhoBTB1 [PMID: 29053138].
-   Hypertension is one of the most pronounced preventable risk factors for cardiovascular disease. Rhobtb1 deficiency has been associated with hypertension. RhoBTB1 reverses established arterial stiffness in angiotensin II-induced hypertension model by promoting actin depolymerization [PMID: 35358093].
-   Mice selectively expressing a PPARgamma dominant-negative mutation in vascular smooth muscle exhibit RhoBTB1 deficiency and hypertension. RhoBTB1 augmented the cyclic 3',5'-monophosphate (cGMP) response to NO by restraining the activity of phosphodiesterase 5 (PDE5) through its action as a substrate adaptor delivering PDE5 to the Cullin-3 E3 ring ubiquitin ligase complex for ubiquitination, thereby inhibiting PDE5 and protecting against hypertension and arterial stiffness [PMID: 30896450].
