
## **Compounds that increase expression of the gene:**

-   (S)-colchicine [PMID: 27358234]
-   1-naphthyl isothiocyanate [PMID: 23411599, PMID: 25380136, PMID: 26011634]
-   19-Nor-17alpha-pregn-5(10)-en-20-yne-3alpha,17beta-diol [PMID: 16019103]
-   1H-pyrazole [PMID: 17945193]
-   2-acetamidofluorene [PMID: 21607683, PMID: 10708481, PMID: 19167416, PMID: 22213190, PMID: 22584684]
-   2-nitrotoluene [PMID: 15618236]
-   4,4'-diaminodiphenylmethane [PMID: 25380136]
-   5-aza-2'-deoxycytidine [PMID: 25549359]
-   5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole [PMID: 27358234]
-   Carbadox [PMID: 26558467]
-   Echimidine [PMID: 32419051]
-   Heliotrine [PMID: 32419051]
-   Lasiocarpine [PMID: 32419051]
-   Leucomalachite green [PMID: 26558467]
-   N-nitrosodimethylamine [PMID: 25380136]
-   N-nitrosomorpholine [PMID: 10326863, PMID: 19716841]
-   O-methyleugenol [PMID: 15618236, PMID: 23411599, PMID: 26011634]
-   Paraoxon-methyl [PMID: 18418871]
-   Senkirkine [PMID: 32419051]
-   Triptolide [PMID: 23639586, PMID: 32835833]
-   aflatoxin B1 [PMID: 23385219, PMID: 23630614, PMID: 25378103, PMID: 22100608, PMID: 28943387, PMID: 29445054]
-   anthracen-2-amine [PMID: 23038007]
-   apigenin [PMID: 16023288]
-   arsane [PMID: 11134558]
-   arsenic atom [PMID: 11134558]
-   arsenite(3-) [PMID: 33010264]
-   arsenous acid [PMID: 15073043, PMID: 21649584, PMID: 17487067]
-   atrazine [PMID: 24211529]
-   azathioprine [PMID: 27358234]
-   benzo[a]pyrene [PMID: 18418871, PMID: 30562542, PMID: 15459018, PMID: 21964900, PMID: 23853263]
-   berberine [PMID: 23747414]
-   bromobenzene [PMID: 32479839]
-   cannabidiol [PMID: 31052254]
-   cisplatin [PMID: 22023808, PMID: 27358234, PMID: 33545341]
-   curcumin [PMID: 17602960]
-   cyclophosphamide [PMID: 29445054]
-   danazol [PMID: 27358234]
-   dexamethasone [PMID: 9442036]
-   diarsenic trioxide [PMID: 21649584, PMID: 15073043, PMID: 17487067]
-   diclofenac [PMID: 19022234, PMID: 19022234]
-   dioscin [PMID: 29990575]
-   doxorubicin [PMID: 22712078, PMID: 16857806]
-   ethanol [PMID: 34192554, PMID: 34405320, PMID: 34192554, PMID: 34405320]
-   etoposide [PMID: 25914138, PMID: 27358234]
-   fenbendazole [PMID: 23411599]
-   fenvalerate [PMID: 30307764]
-   furan [PMID: 20194422, PMID: 23853263, PMID: 24183702, PMID: 37517673]
-   gamma-hexachlorocyclohexane [PMID: 17785943]
-   glafenine [PMID: 24136188]
-   hesperidin [PMID: 34984768]
-   indometacin [PMID: 27358234]
-   irinotecan [PMID: 15754201]
-   leflunomide [PMID: 28988120]
-   lipopolysaccharide [PMID: 27339419]
-   lomustine [PMID: 27358234]
-   menadione [PMID: 23410634]
-   methapyrilene [PMID: 25242409, PMID: 26558467, PMID: 28935588, PMID: 30467583]
-   oleanolic acid [PMID: 18706400]
-   omeprazole [PMID: 27358234]
-   orlistat [PMID: 30667213]
-   ortho-Aminoazotoluene [PMID: 15346788]
-   oxazepam [PMID: 15618236]
-   oxfendazole [PMID: 26558467]
-   oxycodone [PMID: 23439660]
-   ozone [PMID: 20123758, PMID: 33662111]
-   panaxydol [PMID: 19450571]
-   parathion-methyl [PMID: 18418871]
-   perfluorobutyric acid [PMID: 36251517]
-   perfluorooctanoic acid [PMID: 25868421, PMID: 32068100, PMID: 36251517]
-   phorbol 13-acetate 12-myristate [PMID: 24211529]
-   piperonyl butoxide [PMID: 23411599]
-   pirinixic acid [PMID: 18445702]
-   pregnenolone 16alpha-carbonitrile [PMID: 28903501]
-   rubitecan [PMID: 21695227]
-   senecionine [PMID: 32419051, PMID: 35357534]
-   tacrine [PMID: 27358234]
-   teniposide [PMID: 25914138]
-   thioacetamide [PMID: 22659510, PMID: 23411599, PMID: 25242409, PMID: 26011634, PMID: 26558467, PMID: 34492290]
-   titanium dioxide [PMID: 21067279]
-   trichloroethene [PMID: 25549359, PMID: 31942800]
-   tris(2-chloroethyl) phosphate [PMID: 28886428]
-   trovafloxacin [PMID: 25748550, PMID: 35537566]
-   vorinostat [PMID: 15754201, PMID: 20962572]
-   zebularine [PMID: 23320119]

## **Compounds that decrease expression of the gene:**

-   (-)-epigallocatechin 3-gallate [PMID: 18851785]
-   17beta-estradiol [PMID: 23684557]
-   3-methyl-3H-imidazo[4,5-f]quinolin-2-amine [PMID: 22094457]
-   5-fluorouracil [PMID: 15754201]
-   Aroclor 1254 [PMID: 17851650]
-   Cinobufagin [PMID: 21215801]
-   DDT [PMID: 23684557]
-   Dimefox [PMID: 18418871]
-   Nodularin [PMID: 30562542]
-   beta-naphthoflavone [PMID: 19389873, PMID: 22687991]
-   calciol [PMID: 24451003]
-   cerium trichloride [PMID: 23139204]
-   cholic acid [PMID: 27151938]
-   clofibrate [PMID: 17585979]
-   diethanolamine [PMID: 16014740, PMID: 16014740]
-   digitonin [PMID: 36030841]
