
-   Size: 1073 amino acids
-   Molecular mass: 123403 Da
-   Protein Accession: P25092
-   Domains: Kinase-like_dom_sf, Prot_kinase_dom, Ser-Thr/Tyr_kinase_cat_dom, A/G_cyclase, A/G_cyclase_CS, Nucleotide_cyclase, Peripla_BP_I, GC-C_PK
-   Family: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
-   Blocks: Extracellular ligand-binding receptor
-   Guanylyl cyclase C (GCC) is the receptor for the family of guanylin peptides and bacterial heat-stable enterotoxins (ST). The receptor is composed of an extracellular, ligand-binding domain and an intracellular domain with a region of homology to protein kinases and a guanylyl cyclase catalytic domain. The protein kinase domain is predicted to be catalytically inactive. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Trimeric state of GCC is catalytically active, and sequences required to generate the trimer are present in the intracellular domain of GCC [PMID: 11123935]. Interacts via its C-terminal region with NHERF4 [PMID: 11950846]. GCC also interacts with the lectin chaperone VIP36 [PMID: 23269669].
