
-   Protein Accession: Q9NQ31
-   Size: 210 amino acids
-   Molecular mass: 23114 Da
-   Domains: AKIP1
-   Family: None
-   AKIP1 forms a complex with NF-kB subunit RELA and PKA (Protein Kinase A) catalytic subunit (PKAc). This interaction is essential for its role in various cellular processes, including apoptosis regulation and PKA signaling. AKIP1 increased the PKAc binding to p65 and enhanced the PKAc-mediated phosphorylation of p65 at Ser-276. [PMID: 18178962]. This gene enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. PKA-interacting protein (AKIP1) that binds to the amino terminus (residues 1-39) of the C subunit of PKA. The interaction was localized to the A helix (residues 14-39) of the C subunit and to the carboxyl terminus of AKIP1. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade [PMID: 15630084].
