
-   Protein Accession: P49716
-   Size: 269 amino acids
-   Molecular mass: 28467 Da
-   Domains: bZIP, bZIP_sf, C/EBP, C/EBP_chordates
-   Family: Belongs to the bZIP family. C/EBP subfamily
-   LAP/C/EBPb expression is directly linked to a small region in its promoter located 60 to 120 bp upstream of the start site of transcription. CREB binds to two sites within this region of the C/EBP beta promoter, which are important to maintain both basal promoter activity and LAP/C/EBP beta inducibility. This study indicates a functional link between the induction of CREB phosphorylation and C/EBP beta mRNA transcription during liver regeneration [PMID: 9199295]. C/EBPdelta promoter sequences to -125 bp are sufficient for IL-6 inducibility of the gene expression and include an APR element (APRE) that is essential for IL-6 responsiveness [PMID: 9528783].
