
-   The transcripts encoding laminin gamma 2 chain was synergistically activated by HGF and TGF-beta in human colon carcinoma cells. The activation of LAMC2 requires the 5' activator protein-1 (AP-1) element of the promoter and an additional upstream element which is also responsive to co-expression of the Smad3 protein from the TGF-beta signalling pathway. Thus the synergistic activation of the LAMC2 gene results in an overproduction of the laminin gamma 2 chain in the cells at the invasive front of colon carcinomas [PMID: 12519076].
-   TGF-alpha, TGF-beta1 or their combination increased the gene expression levels of all three laminin genes (LAMA3, LAMB3, LAMC2) as compared to nontreated control keratinocytes [PMID: 15541073].
