One-way ANOVA Data Source: rat_2D_OV_No0 Work Source: null BMDExpress3 Version: BMDExpress 3.20.0132 BETA Timestamp (Start Time): 08/26/2025 09:09.29 Adjusted P-Value Cutoff: 0.05 Multiple Testing Correction: true Filter Out Control Genes: true NOTEL/LOTEL Test: T-Test NOTEL/LOTEL p-Value Threshold: 0.05 NOTEL/LOTEL Fold Change Threshold: 2.0 Total Run Time: 0 seconds Chip: BioSpyder S1500_Rat Provider: BioSpyder Chip File Creation Date: 10/31/24 Log Transformation: BASE2 BMDExpress3 Version: BMDExpress 3.20.0119 BETA Timestamp: 04/30/2025 12:12.19 Probe ID Gene ID Gene Symbol Df1 Df2 F-Value Unadjusted P-Value Adjusted P-Value Max Fold Change Max Fold Change Unsigned FC Dose Level 1 FC Dose Level 2 FC Dose Level 3 FC Dose Level 4 FC Dose Level 5 FC Dose Level 6 NOTEL/LOTEL T-Test p-Value Level 1 NOTEL/LOTEL T-Test p-Value Level 2 NOTEL/LOTEL T-Test p-Value Level 3 NOTEL/LOTEL T-Test p-Value Level 4 NOTEL/LOTEL T-Test p-Value Level 5 NOTEL/LOTEL T-Test p-Value Level 6 NOTEL LOTEL DBP_8439 24309 dbp 6 33 6.547974845984306 1.2647372813634483E-4 0.016378347793656656 2.44092 2.44092 -1.684619 -1.123082 1.2876542 -1.0183394 1.3678807 2.44092 0.060870893 0.5149159 0.23945117 0.9501647 0.16076319 5.4522658E-5 250.0 500.0 PPP1R15A_9544 171071 ppp1r15a 6 33 5.094377249706793 8.487003620072375E-4 0.04089551511811619 1.2565821 1.2565821 -1.2447594 -1.0258762 -1.0420038 1.1118041 1.154217 1.2565821 0.03496251 0.7358593 0.6560761 0.121139236 0.16258906 0.009401766 LOC102553917_33088 102548633;102551714 znf431l;zfp120l2 6 33 5.413939848402324 5.491741077077172E-4 0.034604558248635016 1.646009 1.646009 -1.2999543 -1.3320688 1.0196307 1.043741 -1.0671997 1.646009 0.1948257 0.076210074 0.8867505 0.7411846 0.58739734 0.002347737 CCDC86_8215 293738 ccdc86 6 33 5.280871137324608 6.575257977491367E-4 0.036178446533937765 1.2859248 1.2859248 1.2278923 1.0759761 1.138398 1.009033 1.2859248 1.066036 0.0017294673 0.15412076 0.17290014 0.8702127 0.0022770811 0.100247905 HMGCS1_8811 29637 hmgcs1 6 33 4.990516853421893 9.797554435759803E-4 0.0461375745247598 -3.195043 3.195043 1.6473421 -1.1315254 1.4329216 -1.3826028 -1.0298169 -3.195043 0.047268625 0.7235034 0.167184 0.37080783 0.9360811 0.0018447564 250.0 500.0 NDUFV3_32394 64539 ndufv3 6 33 7.3586115172491064 4.7385111422659776E-5 0.014025992981107294 -1.2765306 1.2765306 -1.2765306 -1.1510569 1.0328815 1.0116407 1.0923287 1.2385621 0.023769222 0.047170177 0.44897965 0.81314635 0.42524162 7.775614E-4 KLF6_8969 58954 klf6 6 33 6.971842725265824 7.519021535951076E-5 0.015011116818193433 1.7177085 1.7177085 -1.1606789 -1.1804036 -1.0493752 1.0840706 -1.194861 1.7177085 0.30261174 0.1831061 0.738672 0.48073244 0.14317805 4.9579063E-5 CDK19_8265 309804 cdk19 6 33 4.9499672382814275 0.0010365491423814932 0.047512544135692565 -1.1400005 1.1400005 -1.1400005 -1.1132823 -1.0432826 1.1340972 1.1182686 1.136788 0.11371155 0.18581466 0.5053726 0.13888112 0.029530985 0.0018096209 HSPA8_8845 688655;688932;689955;680121;24468 hspa8-ps22;hspa8-ps23;hspa8-ps25;haus8l2;hspa8 6 33 5.890534454544608 2.9211193820288806E-4 0.023279074459860924 -1.2677613 1.2677613 1.0477144 1.0295821 -1.0673027 -1.1494874 -1.2677613 -1.1207756 0.5327828 0.60517025 0.2946059 0.01175087 4.808727E-4 0.012877748 HSPD1_8849 63868 hspd1 6 33 5.389151254814889 5.678354152768295E-4 0.034604558248635016 1.6430521 1.6430521 1.6430521 1.3290713 1.139327 1.0412594 1.1674757 -1.1885289 0.0012543711 0.0095314095 0.43241808 0.7483651 0.20166117 0.09623972 GBP4_8692 310917 gbp4 6 33 7.903121256751892 2.5228415093558887E-5 0.013068319018463503 -2.0414162 2.0414162 -1.5583974 -1.0200197 -1.0008663 -1.1922895 1.2267123 -2.0414162 0.01691609 0.8820851 0.99552846 0.27498022 0.19469121 5.5839784E-5 250.0 500.0 LEF1_32825 161452 lef1 6 33 5.778844265306162 3.380486928723503E-4 0.02415299626315551 1.4315293 1.4315293 -1.1697407 1.0237017 1.0993752 1.1506883 1.186413 1.4315293 0.04981424 0.8049918 0.21618123 0.060828786 0.12785953 0.011798381 COL6A3_33029 367313 col6a3 6 33 6.312538056535166 1.6994006488946223E-4 0.01956198969172032 -1.8830305 1.8830305 -1.2477115 -1.074416 -1.0252572 -1.1871893 -1.0813475 -1.8830305 0.1908781 0.37684318 0.8108705 0.27122867 0.42733246 9.878757E-6 ECI2_8521 291075 eci2 6 33 5.326960583101839 6.176516308171731E-4 0.036178446533937765 1.2097746 1.2097746 -1.0653642 -1.0327545 1.0879035 1.1009668 1.2097746 1.1938952 0.31628057 0.5043255 0.22792102 0.12929305 0.020028183 3.178466E-4 VPS28_10158 300052 vps28 6 33 5.634901115769735 4.0875332421319577E-4 0.02823122959232472 1.1816238 1.1816238 -1.1012242 -1.0828067 -1.0559373 -1.015007 -1.0131723 1.1816238 0.18295085 0.23264103 0.1645849 0.6423943 0.7692141 4.1258976E-5 WDTC1_10172 313020 wdtc1 6 33 7.413863715015406 4.440334025845871E-5 0.014025992981107294 -1.1920023 1.1920023 -1.1920023 -1.0908672 -1.1013217 1.0311954 1.0218025 1.1455334 0.007267292 0.13603818 0.014331131 0.44577453 0.7311765 0.034573592 RET_32982 24716 ret 6 33 6.176756622248249 2.0194771069381723E-4 0.02062840781605472 1.5954561 1.5954561 -1.2239661 -1.1355479 -1.0146258 -1.0385034 -1.4164125 1.5954561 0.23446189 0.25280243 0.8782851 0.72573113 0.063252755 0.0049879206 MBTPS1_9203 89842 mbtps1 6 33 5.265746990313101 6.71193216275956E-4 0.036178446533937765 -1.1258557 1.1258557 -1.1258557 -1.0964497 1.0060376 -1.029541 1.039469 1.1196026 0.0052146064 0.017714895 0.8759479 0.48708126 0.49100465 0.073695846 NCK2_9287 316369 nck2 6 33 6.424480061113168 1.4758313694884784E-4 0.017987779985765454 -1.3453476 1.3453476 -1.3453476 -1.1918435 1.022922 1.0165174 -1.0164865 1.3235093 0.04552283 0.019704998 0.69137025 0.873407 0.85136604 0.012902781 JAK2_8935 24514 jak2 6 33 6.999511653419224 7.271823411192369E-5 0.015011116818193433 1.4164628 1.4164628 -1.3352443 -1.1715715 1.0056453 1.0483601 1.1081171 1.4164628 3.4059386E-4 0.15156378 0.9634199 0.6343427 0.2909874 0.0027693873 BMF_8152 246142 bmf 6 33 6.250125995510407 1.8393148161988115E-4 0.020058212100862827 1.690684 1.690684 -1.3590462 -1.2229081 -1.1533635 1.0865476 1.0320741 1.690684 0.04714362 0.100773975 0.39297155 0.3929428 0.8396919 0.008911776 FOXO4_8663 302415 foxo4 6 33 6.786085470912931 9.426145805158104E-5 0.015011116818193433 -1.2451931 1.2451931 -1.2451931 -1.113742 -1.1402493 1.0205882 1.0782275 1.1590303 0.023170967 0.16180523 0.057392687 0.5907285 0.31472287 0.038022846 SDPR_32765 316384 cavin2 6 33 5.255130993306625 6.809649685441954E-4 0.036178446533937765 1.432689 1.432689 -1.0349267 1.0161822 1.06265 1.0888042 1.2368816 1.432689 0.61303604 0.85486406 0.357328 0.29202646 0.023612363 0.008839955 PSME2_9604 100362709;29614 loc100362709;psme2 6 33 10.347678599934738 1.913420526244991E-6 0.003964607330379621 -1.2930646 1.2930646 1.2569319 1.1645918 1.204739 -1.021684 1.1816727 -1.2930646 0.008647245 0.038981926 0.0021946267 0.7932376 0.019242384 0.007920106 LOC102549726_32764 102549726 loc102549726 6 33 5.891578133273868 2.917151092459713E-4 0.023279074459860924 1.1738398 1.1738398 -1.120737 -1.091239 -1.123616 -1.0525619 -1.0576065 1.1738398 0.021465534 0.05323553 0.05343032 0.32604125 0.24461387 0.054854896 PIR_9487 363465 pir 6 33 5.1094697741281045 8.31246726243573E-4 0.04089551511811619 1.3129984 1.3129984 -1.2248632 1.073886 1.064294 -1.0142121 1.2608968 1.3129984 0.10869469 0.09823474 0.61423105 0.8668299 0.015192366 0.023051457 ATP5L_33116 300677 atp5mg 6 33 4.921988155219746 0.001077745933579899 0.047512544135692565 1.3238878 1.3238878 -1.0343994 -1.0473667 1.1421045 1.0480323 1.3238878 -1.0815927 0.710605 0.42804435 0.091053285 0.40484095 0.028646437 0.1898899 MEST_9219 58827 mest 6 33 5.40553675450486 5.554267419936032E-4 0.034604558248635016 2.3857608 2.3857608 -1.1246272 1.0592853 1.2311991 1.0434502 1.234758 2.3857608 0.48637378 0.7106138 0.33625737 0.8570506 0.17772666 1.2302703E-4 250.0 500.0 ST6GALNAC2_9951 303692 st6galnac2 6 33 8.024194745736215 2.199513903800021E-5 0.013068319018463503 1.9164369 1.9164369 -1.0891447 1.0323026 1.0528283 1.0502928 1.4071451 1.9164369 0.6371749 0.66917366 0.5943925 0.6467238 0.016471524 5.839764E-4 GADD45G_33229 291005 gadd45g 6 33 5.135161781768032 8.023977509394875E-4 0.04055044243772239 2.1135638 2.1135638 -1.3297343 -1.3627034 1.3850493 1.0100707 1.2005367 2.1135638 0.060410574 0.020518372 0.28993222 0.96381503 0.2289464 0.023845978 250.0 500.0 PAF1_9412 361531 paf1 6 33 6.727149069916098 1.0133071834883545E-4 0.015011116818193433 -1.2460359 1.2460359 -1.2460359 -1.1858505 1.0126373 -1.0567336 -1.0053216 1.1143639 0.004361319 0.042680774 0.78778976 0.421566 0.9190122 0.008788157 LYRM1_9169 365361 lyrm1 6 33 6.700543022813818 1.0470336866585939E-4 0.015011116818193433 1.5603303 1.5603303 1.0309783 -1.0418137 1.202057 1.0259169 1.3253365 1.5603303 0.52460593 0.3000707 0.24108316 0.43968222 0.07524364 0.0035979704 DCK_8440 79127 dck 6 33 5.228216988333853 7.064151736032587E-4 0.0365923059926488 1.2096922 1.2096922 -1.0369776 -1.0881116 1.050788 -1.0137986 1.1110275 1.2096922 0.11744589 0.25717017 0.41086668 0.70896065 0.1260392 0.0056689875 COL4A1_8355 290905 col4a1 6 33 5.8547984237930235 3.0604851078275264E-4 0.023486389420069018 -1.7123605 1.7123605 1.0662442 1.0976267 -1.0616528 -1.23153 1.1929679 -1.7123605 0.6177178 0.54847515 0.67693615 0.02883155 0.18320702 9.127864E-4 PLAC8_32356 360914 plac8 6 33 5.931937061294552 2.767973170422211E-4 0.023279074459860924 -2.024729 2.024729 -1.3253536 1.1209122 1.0067776 -1.0490363 1.0351138 -2.024729 0.08415358 0.15065514 0.9705344 0.7587434 0.8228788 0.0033303131 250.0 500.0 LOC679794_32681 100363502;25309 cycs-ps9;cycs 6 33 6.058966584254236 2.3486897313562682E-4 0.022120386924409943 1.2008954 1.2008954 1.2008954 1.0111452 1.1815696 1.035671 1.1368647 -1.176446 0.023234712 0.87800276 0.025140474 0.39614674 0.16713205 8.593704E-4 MAPT_32343 29477 mapt 6 33 5.945179026168294 2.7207963344977326E-4 0.023279074459860924 -1.4869641 1.4869641 -1.3144673 -1.2774062 -1.2120638 -1.4869641 1.145944 1.426381 0.107037716 0.24473205 0.2920024 0.008802541 0.063597694 4.3662416E-4 F3_32469 25584 f3 6 33 6.149631026303428 2.0907170083839244E-4 0.02062840781605472 2.4030943 2.4030943 -1.0214686 -1.0033664 1.1113236 -1.1291468 -1.0757865 2.4030943 0.88202125 0.98671025 0.5764164 0.5885854 0.64381754 6.614438E-5 250.0 500.0 OAS1A_9388 192281 oas1a 6 33 5.267896617980865 6.692325574422231E-4 0.036178446533937765 -1.7436715 1.7436715 -1.483811 -1.0668293 1.1026624 1.069917 1.0227845 -1.7436715 0.004398421 0.7360281 0.530368 0.5634229 0.8900155 3.2385328E-4 Ace_34123 24310 ace 6 33 4.933467318773053 0.0010606395474360708 0.047512544135692565 1.7541115 1.7541115 -1.1508456 -1.0230134 -1.0392501 1.1447171 1.2334923 1.7541115 0.4697817 0.8524902 0.7283966 0.1658652 0.0975068 0.0099820355 ISG15_8918 298693 isg15 6 33 4.898221644516231 0.001114090831985326 0.0480915875806999 -1.9745084 1.9745084 -1.1052927 1.4337801 1.5084925 -1.0210277 1.4182844 -1.9745084 0.6169051 0.18224888 0.09374122 0.9210014 0.19465046 0.0013069623 CORO1A_8364 155151 coro1a 6 33 6.670376037456997 1.0867121248692158E-4 0.015011116818193433 -1.5600951 1.5600951 -1.1020092 1.0780455 -1.0269598 -1.1926738 1.2347466 -1.5600951 0.40005746 0.40167806 0.81734973 0.07200236 0.034725893 0.0042032544 SMAD5_9893 59328 smad5 6 33 7.396154600870621 4.5336848492727455E-5 0.014025992981107294 1.2749174 1.2749174 -1.1224155 -1.0980117 1.0238647 -1.0192842 1.0164052 1.2749174 0.034971118 0.14488855 0.6103495 0.7407676 0.8108234 0.0016657163 TGFBR2_10008 81810 tgfbr2 6 33 5.41656977135076 5.472324684114849E-4 0.034604558248635016 1.3152683 1.3152683 -1.2545321 -1.0582939 1.0551233 -1.0508919 1.233891 1.3152683 0.020425463 0.60276586 0.56811625 0.5590375 0.090669155 0.0018885919 LY86_9165 291359 ly86 6 33 8.583686472053474 1.1829782882388784E-5 0.01225565506615478 -1.8784026 1.8784026 -1.3086698 1.0880362 1.0265983 -1.1427087 1.059757 -1.8784026 0.014889043 0.31554312 0.8458112 0.10685182 0.6882551 8.1976654E-4 SELE_32346 25544 sele 6 33 6.817685784450239 9.068723250871269E-5 0.015011116818193433 2.3714383 2.3714383 1.1691886 1.5642035 1.954442 1.1715928 2.3714383 1.4503813 0.3629727 0.013612396 0.015338831 0.18598329 0.0025982803 0.013897043 100.0 250.0 PINK1_32483 298575 pink1 6 33 5.786255506371548 3.347765052819085E-4 0.02415299626315551 1.2024901 1.2024901 -1.1215338 -1.0419339 -1.0942345 -1.0400556 -1.0808004 1.2024901 0.038989227 0.5063988 0.052313298 0.40294105 0.2967411 0.0017336042 HSDL2_8837 313200 hsdl2 6 33 6.697141297987415 1.0514304613229442E-4 0.015011116818193433 1.1852556 1.1852556 -1.1330923 -1.1299078 1.0997641 1.0367553 1.1708387 1.1852556 0.057554267 0.067905836 0.06573128 0.3424143 0.11273257 0.022360465