Curve Fit Prefilter Data Source: mouse_2D_OV_williams_0.05_NOMTC_nofoldfilter Work Source: mouse_2D_OV BMDExpress3 Version: BMDExpress 3.20.0119 BETA Timestamp (Start Time): 04/30/2025 12:23.27 Constant Variance: 1 BMR Factor: 2.0 Poly 2 BMR Factor: 5.0 Models Used: hill: Hill EPA BMDS MLE ToxicR,power: Power EPA BMDS MLE ToxicR,linear: Linear EPA BMDS MLE ToxicR,exponential 3: Exponential 3 EPA BMDS MLE ToxicR,exponential 5: Exponential 5 EPA BMDS MLE ToxicR, NOTEL/LOTEL Test: T-Test NOTEL/LOTEL p-Value Threshold: 0.05 NOTEL/LOTEL Fold Change Threshold: 2.0 Total Run Time: 31 seconds Williams Trend Test Data Source: mouse_2D_OV Work Source: null BMDExpress3 Version: BMDExpress 3.20.0119 BETA Timestamp (Start Time): 04/30/2025 12:13.54 Number of Permutations: 10000 Unadjusted P-Value Cutoff: 0.05 Multiple Testing Correction: false Filter Out Control Genes: true NOTEL/LOTEL Test: T-Test NOTEL/LOTEL p-Value Threshold: 0.05 NOTEL/LOTEL Fold Change Threshold: 2.0 Total Run Time: 23 seconds Chip: BioSpyder S1500_Mouse Provider: BioSpyder Chip File Creation Date: 10/31/24 Log Transformation: BASE2 BMDExpress3 Version: BMDExpress 3.20.0119 BETA Timestamp: 04/30/2025 12:11.51 Probe ID Gene ID Gene Symbol Best Model Best BMD Best BMDL Goodness of Fit Max Fold Change Max Fold Change Unsigned FC Dose Level 1 FC Dose Level 2 FC Dose Level 3 FC Dose Level 4 FC Dose Level 5 NOTEL/LOTEL T-Test p-Value Level 1 NOTEL/LOTEL T-Test p-Value Level 2 NOTEL/LOTEL T-Test p-Value Level 3 NOTEL/LOTEL T-Test p-Value Level 4 NOTEL/LOTEL T-Test p-Value Level 5 NOTEL LOTEL Cetn3_30290 12626 cetn3 Exp 5 4.0199 0.730662 0.9981433521375258 1.1739694 1.1739694 1.0645785 1.141898 1.1739694 1.158658 1.1729927 0.18295062 2.5259133E-4 4.6250803E-4 6.7953963E-4 4.5035653E-5 Tmem182_30628 381339 tmem182 Hill 1.49273 1.56746E-15 0.7983633478711826 3.151572 3.151572 1.2622678 3.0816576 2.1256561 2.5772762 3.151572 0.5224985 8.8755164E-4 0.013553765 0.01214495 5.090558E-4 1.0 10.0 Bcat1_31806 12035 bcat1 Power 248.663 222.769 0.6497140060441642 -1.3807675 1.3807675 -1.1096286 -1.0020672 1.0338802 -1.0267806 -1.3807675 0.32512856 0.9838956 0.69068396 0.6745313 0.0022516616 Timm9_30419 30056 timm9 Exp 5 29.606 10.1025 0.796852529095446 1.2736951 1.2736951 1.0472353 1.0943929 1.1352913 1.2736951 1.2404212 0.42381757 0.058573958 0.004973471 8.371833E-6 2.0806068E-5 Cenpe_30836 229841 cenpe Exp 5 163.717 6.09438 0.9170731206723397 1.5554407 1.5554407 1.1159724 1.1969202 1.2490352 1.2632599 1.5554407 0.32878295 0.11510691 0.091639444 0.079435214 8.057431E-5 Fam63a_31044 75007 mindy1 Hill 10.2241 1.62837 0.8502895428874577 -1.4224638 1.4224638 -1.0067048 -1.3087062 -1.2947974 -1.298532 -1.4224638 0.95533466 0.0011929052 0.0012801447 0.003463811 7.0255475E-5 Syn1_30750 20964 syn1 Exp 5 3.76194 1.54958 0.9907297701389788 -2.7818775 2.7818775 -1.4696184 -2.4499924 -2.5420666 -2.399448 -2.7818775 0.13252182 3.7774687E-5 0.0017380846 4.3581854E-4 8.057963E-4 1.0 10.0 Elovl6_32029 170439 elovl6 Power 249.723 244.389 0.24068044064117522 -1.9483562 1.9483562 -1.0440743 1.002634 -1.3027983 1.1996224 -1.9483562 0.8256825 0.9881618 0.11785086 0.32690227 0.0014440621 Dis3_30964 72662 dis3 Exp 5 135.809 4.78841 0.8951130111820114 1.2050831 1.2050831 1.0261631 1.1226983 1.1347114 1.1301017 1.2050831 0.6674684 0.02206438 0.047018312 0.021314962 4.047729E-4 Sel1l_30542 20338 sel1l Linear 244.914 164.412 0.3872366040961496 -1.3419857 1.3419857 -1.1077191 -1.0810997 -1.11001 -1.1795982 -1.3419857 0.12685452 0.2191423 0.27434936 0.015086129 0.0011497012 Obox1_31525 71468 obox1 Hill 20.6976 6.04228 0.9648185779861902 1.5218015 1.5218015 -1.0767481 1.229232 1.3930266 1.4773461 1.5218015 0.4714399 0.012078442 0.007263978 0.0010099382 0.0029529624 Mmp12_84187 17381 mmp12 Exp 3 247.608 115.229 0.7632496228126048 3.6954176 3.6954176 -1.0821339 1.1862291 1.3250216 -1.002365 3.6954176 0.80821675 0.52335685 0.3709944 0.99249464 8.9963025E-4 100.0 250.0 Sod3_30579 20657 sod3 Exp 5 220.642 86.838 0.5520739151262308 -1.5238006 1.5238006 1.0093114 -1.1176109 -1.2768277 -1.1517106 -1.5238006 0.92682666 0.31467086 0.14308004 0.24618842 1.6511769E-5 Hba-a1_84120 110257 hba-a2 Power 181.626 134.613 0.8929371724257278 -10.361314 10.361314 1.1713772 1.0842298 -1.2873988 -1.365781 -10.361314 0.6174081 0.78599185 0.34832025 0.28748775 6.3911534E-4 100.0 250.0 Hba-a2_29332 110257 hba-a2 Linear 162.527 120.149 0.816635937698948 -5.7465534 5.7465534 1.1662612 1.0845428 -1.2718337 -1.6146097 -5.7465534 0.6256965 0.82499117 0.51061875 0.17836468 1.3590029E-4 100.0 250.0 Dbp_31391 13170 dbp Exp 5 7.50811 3.69245E-68 0.02352539636451456 2.3497229 2.3497229 -1.379648 2.204411 1.8768518 1.4382904 2.3497229 0.09515064 3.7416878E-5 0.0011069557 0.08530015 7.8068E-5 1.0 10.0 Nckap1l_31716 105855 nckap1l Power 246.177 208.63 0.4088036559926004 1.4881252 1.4881252 1.0224668 -1.2291734 -1.0642289 1.0040122 1.4881252 0.85976607 0.042208336 0.5668315 0.9784897 0.0069998754 Pcolce_31229 18542 pcolce Exp 5 6.83549 1.02514 0.8158285817365691 -1.5471908 1.5471908 -1.1605805 -1.4979612 -1.5471908 -1.3375677 -1.5258462 0.35151422 0.004366037 3.64977E-4 0.0128570255 1.0007159E-4 Slc38a5_30067 209837 slc38a5 Hill 13.095 0.146201 0.8810599489627959 1.6055571 1.6055571 -1.1190184 1.363769 1.5242454 1.4376687 1.6055571 0.38928202 0.078376345 0.003569212 0.03221631 1.9802076E-4 Tacc3_30034 21335 tacc3 Hill 35.6669 2.67316 0.7894829059236155 1.4822782 1.4822782 1.0326221 1.1356959 1.3665798 1.2998791 1.4822782 0.68581176 0.14768101 0.002913288 0.021779137 4.281295E-4 Fbn1_30622 14118 fbn1 Hill 105.173 16.3686 0.915754268740646 -1.2904623 1.2904623 1.0582733 -1.0939705 -1.1364337 -1.2313325 -1.2904623 0.44087407 0.14904833 0.21644293 0.01186064 2.9707083E-4 Npdc1_29266 18146 npdc1 Linear 247.416 166.332 0.653540556591254 -1.3765256 1.3765256 1.0624962 -1.0138918 1.0043339 -1.0397669 -1.3765256 0.6175742 0.8947831 0.9690844 0.62862694 4.7053635E-4 Hsd3b1_30309 15492 hsd3b1 Exp 5 6.49796 1.06852 0.5531682636471338 -1.7649039 1.7649039 -1.1434723 -1.5529072 -1.6091676 -1.4104595 -1.7649039 0.27037057 0.0014801136 3.6676938E-4 0.015178984 1.5546022E-4 Map1lc3a_84151 66734 map1lc3a Exp 5 95.9816 0.0522271 0.9997827890779342 -1.3220185 1.3220185 -1.079076 -1.2248049 -1.2548921 -1.3073015 -1.3220185 0.52251667 0.019660285 0.013183309 0.00210821 0.0014645152 Ctla2a_30798 13024 ctla2a Exp 5 237.779 37.3547 0.9902026340067052 -1.594778 1.594778 1.0005968 -1.2226815 -1.242571 -1.4090011 -1.594778 0.99626994 0.18532437 0.14818868 0.016889554 0.0054979953 Hat1_30881 107435 hat1 Exp 5 196.795 21.4457 0.6651579670015714 1.2509522 1.2509522 1.0297387 1.1263154 1.1845804 1.1206222 1.2509522 0.58161175 0.07062492 0.037160482 0.052801862 9.542191E-4 Cdk6_29089 12571 cdk6 Exp 5 117.429 42.3458 0.9641152904145596 1.3136247 1.3136247 -1.0053704 1.0973939 1.0891451 1.2326026 1.3136247 0.91786283 0.103561446 0.21304221 0.029745234 7.952677E-4 Oog2_29965 381570 oog2 Hill 27.4488 4.56036 0.9669412314694592 1.5544313 1.5544313 -1.053428 1.2629656 1.3941551 1.4465132 1.5544313 0.6038185 0.018138293 0.019483082 0.007808904 0.0016238419 Igf2bp2_31560 319765 igf2bp2 Exp 5 175.968 0.500187 0.9963235320355533 1.3369154 1.3369154 1.0569572 1.1533638 1.1759413 1.2203817 1.3369154 0.64478177 0.08880199 0.0077481773 0.0056759277 7.1522343E-4 Ndufa5_84190 68202 ndufa5 Exp 5 103.178 18.8488 0.8323324335945703 1.1413208 1.1413208 1.0372831 1.0412229 1.0532126 1.1413208 1.136 0.23064134 0.12607026 0.11697078 2.8598102E-4 0.0056264577 Grin2c_31282 14813 grin2c Linear 216.124 149.719 0.10514101280064159 -1.93297 1.93297 -1.1248415 -1.0294373 1.2159312 -1.4399618 -1.93297 0.55632323 0.8973305 0.15933803 0.008601824 2.202079E-4 Itfg1_30888 71927 itfg1 Exp 5 179.848 2.1118 0.6105969404066554 -1.1518157 1.1518157 1.0054811 -1.084665 -1.0790818 -1.077859 -1.1518157 0.9085896 0.025216792 0.097032666 0.023266764 3.4397203E-4 Oosp1_84215 170834 oosp1 Exp 5 19.3484 0.220623 0.9487683488827641 1.5467291 1.5467291 1.005755 1.2619654 1.480018 1.3770398 1.5467291 0.9554137 0.024544695 0.0047942987 0.04808395 7.179349E-4 Ube2t_30503 67196 ube2t Hill 90.2436 8.81828 0.9974405373960904 1.3794359 1.3794359 1.0083672 1.1241649 1.2532047 1.2916801 1.3794359 0.92478484 0.16784222 0.006580878 0.047185704 5.57999E-4 Elovl6_30026 170439 elovl6 Power 249.439 244.191 0.40820272094788546 -1.804172 1.804172 -1.07828 1.0636247 -1.1954778 1.1430072 -1.804172 0.7150813 0.69146484 0.25211 0.36651963 9.196933E-4 Prdx3_29656 11757 prdx3 Exp 5 107.408 0.387369 0.3131493461544749 -1.2383451 1.2383451 -1.0959581 -1.1941668 -1.1419487 -1.1093088 -1.2383451 0.18831831 0.0011648893 0.01228008 0.026922235 1.6513385E-4 Becn1_30105 56208 becn1 Linear 224.913 153.824 0.4409415122900876 -1.176698 1.176698 -1.0150422 -1.0185797 -1.0515076 -1.029408 -1.176698 0.65335405 0.57187736 0.37132484 0.5196832 1.18107135E-4 Pecam1_30950 18613 pecam1 Hill 9.18014 0.204527 0.9992441171088545 -1.5149913 1.5149913 -1.0612944 -1.4509965 -1.476039 -1.4461551 -1.5149913 0.6868261 0.0146038 0.0022303325 1.4010348E-4 0.0019067484 Apoe_31528 11816 apoe Power 247.122 242.508 0.518350335871671 1.419327 1.419327 -1.1595407 -1.0158617 -1.0313246 -1.0481133 1.419327 0.21664603 0.8720197 0.7174239 0.5804633 5.5871333E-4 Arrdc4_31686 66412 arrdc4 Linear 232.877 159.283 0.22001331302773408 -1.4655035 1.4655035 1.0008948 -1.1146336 -1.2063544 -1.1456361 -1.4655035 0.9911206 0.1273015 0.1636956 0.2760684 4.6195044E-5 Aspn_29620 66695 aspn Power 245.495 124.694 0.17924379447308292 -1.5178907 1.5178907 -1.0801094 -1.0027577 -1.0945586 1.1128004 -1.5178907 0.2964905 0.9702872 0.2481385 0.2771157 1.9786306E-4 Rgs2_29422 19735 rgs2 Exp 5 21.4568 0.119911 0.9676407897985717 1.5914649 1.5914649 1.1375577 1.4442067 1.5665953 1.4246478 1.5914649 0.36005595 0.011111801 0.0044058403 0.045249835 5.2054896E-4 Fbxw18_30770 546161 fbxw18 Hill 88.4764 3.80782 0.9441635383864279 1.4549243 1.4549243 -1.1092288 1.1260526 1.2771249 1.4380032 1.4549243 0.42742112 0.28900778 0.07605524 0.014113745 0.0014138 Gng3_30814 14704 gng3 Hill 189.153 4.05938 0.6922156909623225 1.5681812 1.5681812 -1.2191485 1.0720274 1.2640615 1.3709959 1.5681812 0.13635287 0.6802131 0.13610609 0.029357417 0.0032139583 Vim_30043 22352 vim Hill 134.941 0.514078 0.9467910923515622 -1.3799233 1.3799233 1.0240664 -1.2063248 -1.2240182 -1.2988402 -1.3799233 0.8651356 0.033576448 0.04538386 0.003102107 6.2760385E-4 Nsdhl_30986 18194 nsdhl Exp 5 249.769 154.621 0.9644089214401164 -1.477097 1.477097 1.0087252 -1.0922763 -1.1016067 -1.1454506 -1.477097 0.95239794 0.2622364 0.27714518 0.17934255 0.00473058 Chn1_31954 108699 chn1 Exp 5 83.1578 10.057 0.9984078492971856 1.4848113 1.4848113 1.0682802 1.2081108 1.3312749 1.3732293 1.4848113 0.61503536 0.084329754 0.0066450993 0.016041426 3.2244492E-4 Id2_31090 15902 id2 Exp 5 199.455 1.26725 0.9024439487348275 -1.5975118 1.5975118 -1.081068 -1.2963034 -1.3186592 -1.3046818 -1.5975118 0.62860936 0.09436145 0.019742766 0.05025632 2.9565525E-4 Dnajc15_30668 66148 dnajc15 Exp 5 168.131 5.16777 0.22279402729597964 -1.522933 1.522933 -1.0745081 -1.419639 -1.2770877 -1.226114 -1.522933 0.631694 0.0013546079 0.016427219 0.031700216 1.2345018E-4 Adh1_84160 11522 adh1 Hill 9.83665 8.6041 0.04268444433651941 -3.5870485 3.5870485 1.0665206 -2.2467685 -2.6944766 -1.7494899 -3.5870485 0.82881194 0.001283727 1.6714388E-4 0.010847085 8.645213E-6 1.0 10.0 Cox7a1_30621 12865 cox7a1 Exp 5 0.278279 4.91923E-19 0.3456072189728131 -2.2334573 2.2334573 -1.6131604 -2.2334573 -1.6784191 -1.5968431 -1.8887395 0.004791182 0.0016646314 0.009346951 0.026647437 1.8363637E-4 1.0 10.0 Hlf_30768 217082 hlf Hill 3.4825 1.18038E-26 0.0962971372695609 2.198409 2.198409 -1.2983539 2.198409 1.9106688 1.4643351 2.090802 0.18596774 3.251794E-5 8.947131E-4 0.05901906 1.8722609E-4 1.0 10.0 Gsta3_30777 14859 gsta3 Exp 5 241.026 58.3968 0.9709127515138496 2.551349 2.551349 1.3158383 1.269233 1.3742176 1.8959366 2.551349 0.23267958 0.3492321 0.33599842 0.072057545 5.1604776E-4 100.0 250.0 Zg16_29210 69036 zg16 Linear 185.759 133.767 0.0011750913638761684 2.1599133 2.1599133 -1.044308 1.4160681 1.5052489 1.2812458 2.1599133 0.7136917 0.007154223 7.0836744E-4 0.02199235 1.7576257E-4 100.0 250.0 Ruvbl1_29584 56505 ruvbl1 Hill 87.2681 0.0981297 0.9087139291303837 1.1739002 1.1739002 1.0410633 1.1199586 1.105386 1.1714762 1.1739002 0.5123606 0.0051978715 0.015464613 0.0013538315 0.0010355867 Sqstm1_30913 18412 sqstm1 Exp 5 9.13465 1.06873 0.24089810232041953 -1.3484616 1.3484616 -1.0664747 -1.2378876 -1.2719308 -1.1583601 -1.3484616 0.39070883 0.02030166 0.0034136106 0.0035676179 4.17618E-6 Bpgm_30927 12183 bpgm Exp 5 82.6597 18.4732 0.9987928602232897 1.2659534 1.2659534 1.02745 1.1158588 1.139956 1.2114992 1.2659534 0.57814324 0.04322474 0.040768724 0.005326472 0.0016811131 Pik3r3_29609 18710 pik3r3 Power 246.411 241.966 0.5297250791545056 -1.4684048 1.4684048 -1.0286223 -1.0101858 -1.1136473 1.0399277 -1.4684048 0.7933567 0.8439009 0.21846813 0.6986318 6.148686E-5 Cd68_30420 12514 cd68 Power 243.149 239.349 0.552055290398265 1.900053 1.900053 -1.0510955 -1.2039349 -1.122226 -1.1291851 1.900053 0.7290903 0.07300535 0.3236803 0.22097641 8.1872166E-4 Mmp12_31879 17381 mmp12 Power 246.982 242.402 0.4118291877126966 3.864091 3.864091 -1.0522251 1.2966043 1.548158 1.0285639 3.864091 0.87399393 0.35554284 0.11839336 0.9240964 3.8715094E-4 100.0 250.0 Cul1_31957 26965 cul1 Exp 5 140.451 11.2222 0.9597437284362202 1.1240357 1.1240357 -1.0010914 1.047508 1.0491074 1.1240357 1.1237147 0.9805016 0.104062065 0.18374136 0.0038451029 0.002113616 Hbb-bs_84118 101488143 hbb-bt Power 189.92 143.422 0.922109324103509 -9.345654 9.345654 1.3064488 1.1149527 -1.1235803 -1.2836046 -9.345654 0.4737992 0.69339687 0.6585404 0.38828593 0.0013475596 100.0 250.0 Ecm1_29959 13601 ecm1 Exp 5 8.26949 0.638673 0.9992649605818723 -1.6649121 1.6649121 -1.0807415 -1.5844979 -1.6649121 -1.6035737 -1.5750815 0.60267174 0.003913625 0.0025629872 0.009236807 0.0015437643 Psip1_30136 101739 psip1 Exp 5 238.712 0.0823925 0.9990501688364158 1.197935 1.197935 1.025264 1.1097797 1.1278367 1.1792474 1.197935 0.6581936 0.05655474 0.024072388 0.02683227 0.003922142 Gapdh_31215 100042025 gapdh-ps15 Exp 5 133.235 0.416699 0.9999999990373916 -1.294367 1.294367 -1.12409 -1.187815 -1.2236379 -1.2666122 -1.294367 0.28371865 0.005935746 0.02887869 0.0019266439 0.001035892 Lyz2_31340 17105 lyz2 Power 247.925 243.106 0.6238853402274835 1.7422365 1.7422365 1.0316566 -1.1576811 -1.1147463 -1.177659 1.7422365 0.82628125 0.28421247 0.37276736 0.32533094 0.008408044 Gp49a_30210 14727 lilrb4b Linear 234.995 160.091 0.47449642960714333 1.919771 1.919771 1.0047568 -1.1131065 1.0394707 1.0441461 1.919771 0.9736704 0.43402863 0.8382924 0.7818014 0.009763711 Hmmr_30734 15366 hmmr Linear 228.362 155.368 0.12341762481892382 1.5464724 1.5464724 1.1089653 1.1213413 1.2825321 1.222968 1.5464724 0.31481066 0.21709678 0.01332784 0.17104718 7.3289375E-6 Slc6a15_31138 103098 slc6a15 Hill 19.0248 1.10165 0.10054286740190266 1.9162031 1.9162031 -1.0711639 1.4525608 1.4826643 1.3374276 1.9162031 0.6329282 0.012304335 0.0011299321 0.03304635 7.0270544E-5 Trappc6a_30793 67091 trappc6a Linear 210.97 148.61 0.6595394795508375 -1.479258 1.479258 -1.0654544 -1.0065653 -1.1363544 -1.1660858 -1.479258 0.48218095 0.9159425 0.31631207 0.08257105 9.4467925E-4