One-way ANOVA Data Source: rat_4D_HE_No0 Work Source: null BMDExpress3 Version: BMDExpress 3.20.0129 BETA Timestamp (Start Time): 08/14/2025 10:45.26 Adjusted P-Value Cutoff: 0.05 Multiple Testing Correction: true Filter Out Control Genes: true NOTEL/LOTEL Test: T-Test NOTEL/LOTEL p-Value Threshold: 0.05 NOTEL/LOTEL Fold Change Threshold: 2.0 Total Run Time: 0 seconds Chip: BioSpyder S1500_Rat Provider: BioSpyder Chip File Creation Date: 10/31/24 Log Transformation: BASE2 BMDExpress3 Version: BMDExpress 3.20.0119 BETA Timestamp: 04/30/2025 12:12.19 Probe ID Gene ID Gene Symbol Df1 Df2 F-Value Unadjusted P-Value Adjusted P-Value Max Fold Change Max Fold Change Unsigned FC Dose Level 1 FC Dose Level 2 FC Dose Level 3 FC Dose Level 4 FC Dose Level 5 FC Dose Level 6 NOTEL/LOTEL T-Test p-Value Level 1 NOTEL/LOTEL T-Test p-Value Level 2 NOTEL/LOTEL T-Test p-Value Level 3 NOTEL/LOTEL T-Test p-Value Level 4 NOTEL/LOTEL T-Test p-Value Level 5 NOTEL/LOTEL T-Test p-Value Level 6 NOTEL LOTEL DERA_8462 690945 dera 6 33 5.851076189707588 3.0753989435239326E-4 0.018680568421469566 -1.1352069 1.1352069 1.124792 1.0696313 1.0454756 1.079472 -1.1216313 -1.1352069 0.08130605 0.13729589 0.45219362 0.16460524 0.044633444 0.0037807156 LOC102549061_32836 102549061 loc102549061 6 33 9.50758474330172 4.448351574759535E-6 8.104054775341828E-4 -2.3845482 2.3845482 -1.1787155 -1.0930467 -1.2113023 -1.2730154 -1.6116825 -2.3845482 0.27135575 0.46874875 0.10169895 0.1554292 0.008438386 5.4858924E-7 400.0 800.0 NPM1_32887 100363637;25498 npm1-ps19;npm1 6 33 5.916095881151244 2.8255450067671273E-4 0.01834655602669828 -1.1115557 1.1115557 1.0212003 1.0364935 -1.0100416 1.0019195 -1.0635854 -1.1115557 0.59835964 0.07217385 0.6855662 0.94097215 0.023888612 1.0767892E-4 PPARG_9537 25664 pparg 6 33 4.981411664682557 9.922170903795546E-4 0.04485194441588972 -1.4451735 1.4451735 1.1813595 1.1570244 1.1316676 1.0465143 1.0269135 -1.4451735 0.32999155 0.1298496 0.0465489 0.72567743 0.64093214 0.004122626 SPP1_9929 25353 spp1 6 33 5.057968538047574 8.924095155462552E-4 0.04201017794433996 1.9624025 1.9624025 1.0941119 -1.0127176 1.0799434 1.433153 1.2998834 1.9624025 0.4566711 0.91442263 0.63278353 0.06141384 0.051000837 0.008706974 NDRG1_32364 299923 ndrg1 6 33 11.109569319280114 9.214095814114032E-7 2.1687678022470902E-4 -1.5516707 1.5516707 1.0656333 1.1009349 -1.1378955 1.1433347 -1.0860741 -1.5516707 0.46968985 0.19532973 0.06564693 0.053190198 0.26264262 0.0012392025 DBP_8439 24309 dbp 6 33 30.693993881668778 3.744560217455728E-12 2.350335629823045E-9 6.6144853 6.6144853 -1.10826 1.0702742 -1.1497785 1.0829774 1.8890972 6.6144853 0.5014986 0.7121298 0.42911226 0.686896 0.0035432356 1.3204943E-8 400.0 800.0 ARNTL_8086 29657 bmal1 6 33 54.55765624281644 1.1102230246251565E-15 2.0905499553691698E-12 -8.237983 8.237983 1.1057076 1.0782286 1.1018686 1.0984596 -1.4055587 -8.237983 0.46882853 0.47324333 0.33410442 0.49054834 0.18895128 8.131419E-13 400.0 800.0 RGD1565775_9698 361980 khdc4 6 33 5.808949016929561 3.2496280513305553E-4 0.019122030064548236 -1.2802092 1.2802092 -1.0050787 1.1106178 -1.0083832 1.0360013 -1.0020262 -1.2802092 0.9294546 0.027121637 0.9165111 0.51353 0.9721963 1.9131835E-4 LOC100910792_33137 60668 amph 6 33 6.726094549963616 1.0146218651985173E-4 0.00955266486084404 -1.390561 1.390561 1.0768867 1.0625545 -1.0207515 -1.0669485 -1.2037014 -1.390561 0.2656089 0.4532958 0.7765332 0.4114368 0.035370905 0.0010380978 ACY3_32489 293653 acy3 6 33 5.0941563648696615 8.489586443484187E-4 0.04098946480277109 -1.3985925 1.3985925 1.0697052 1.2544603 -1.019475 1.1414049 -1.0638121 -1.3985925 0.47810218 0.027136024 0.88489896 0.17684622 0.42549363 0.015812922 LOXL1_9149 315714 loxl1 6 33 5.687970201246985 3.810261578486296E-4 0.02110212515379322 -1.616321 1.616321 1.0597031 1.0788852 1.0736142 -1.1752245 -1.0596538 -1.616321 0.5154681 0.5401523 0.36153272 0.2678192 0.6274522 4.7554867E-4 FCGR2A_8624 103693683;116591 fcgr2a-ps1;fcgr2a 6 33 9.70922473383626 3.6191248631300965E-6 7.572013463637747E-4 -1.9083649 1.9083649 -1.0022507 1.0437148 1.0521382 -1.0567756 -1.1568264 -1.9083649 0.9766061 0.68489075 0.37248144 0.6856492 0.30044565 6.1808983E-6 INSIG1_8906 64194 insig1 6 33 9.447189898609105 4.734179635090818E-6 8.104054775341828E-4 -1.406431 1.406431 1.0165772 1.0811695 -1.037183 -1.0078927 -1.0510371 -1.406431 0.7996007 0.10835233 0.37201634 0.8798222 0.50591606 1.4469912E-4 HERPUD1_8795 85430 herpud1 6 33 11.52992319683548 6.23755184059327E-7 1.6779014451195895E-4 1.465764 1.465764 1.0044799 1.0228366 -1.0511218 1.1392208 1.153961 1.465764 0.95886904 0.61890197 0.3462834 0.019576427 0.019402802 6.8996894E-7 RT1-DA_9760 294269 rt1-da 6 33 6.683403235393377 1.069386306083997E-4 0.009588830544553173 -1.5857035 1.5857035 1.2534732 1.1101047 1.1382622 -1.1644716 -1.1783015 -1.5857035 0.04811664 0.42072067 0.2810015 0.15501717 0.2608716 3.5291468E-4 HIST1H2BF_33070 306969;306945 h2bc8;hist1h2bq 6 33 8.495558681166157 1.302488448318151E-5 0.001751846962987913 -1.4358604 1.4358604 1.0086135 -1.0021847 -1.0720285 -1.1596936 -1.2408358 -1.4358604 0.91409564 0.9633006 0.10754394 0.033131763 0.047246993 1.1036105E-5 NR1D2_9358 259241 nr1d2 6 33 11.77286260881314 4.998431739622333E-7 1.5686744942848088E-4 2.1057932 2.1057932 -1.0397236 1.2032925 -1.0442175 1.0709989 1.3881414 2.1057932 0.69397414 0.21615814 0.6942346 0.51995057 0.007156256 6.224769E-6 400.0 800.0 ID2_8861 25587 id2 6 33 5.709230358170349 3.704804789921301E-4 0.02110212515379322 -1.4195696 1.4195696 1.0549538 1.0657481 -1.0103649 -1.0671129 -1.0451301 -1.4195696 0.54886645 0.33634678 0.8871003 0.41021845 0.54871905 7.7509135E-4 NPAS2_9350 316351 npas2 6 33 27.848955315090098 1.4046208640650093E-11 6.612252717586031E-9 -4.0854964 4.0854964 -1.02516 -1.0068442 -1.0820453 1.0604361 -1.3897693 -4.0854964 0.88183415 0.9380266 0.5889529 0.50342774 0.0717965 1.9837476E-7 400.0 800.0 CCL7_32689 287561 ccl7 6 33 6.04875509216993 2.3797801623948178E-4 0.01659676313255349 2.160408 2.160408 1.0878487 -1.0890646 1.1436877 -1.3787695 1.1386323 2.160408 0.6658271 0.7175343 0.36964896 0.10817681 0.34956664 6.860563E-5 400.0 800.0 TCAP_32842 688173 tcap 6 33 8.744311053908108 9.939973265482571E-6 0.001462407731902956 2.081941 2.081941 1.0385575 1.1411906 -1.0689552 1.1984291 1.4331895 2.081941 0.73036164 0.21242513 0.65568787 0.17940831 0.032989625 6.0009806E-6 400.0 800.0 EPHX1_8567 25315 ephx1 6 33 21.001553041709276 5.651108470061672E-10 2.1282074498252256E-7 2.3518424 2.3518424 -1.0380917 -1.166204 -1.1779848 -1.0837754 1.0175112 2.3518424 0.6303046 0.12606461 0.1697713 0.5264483 0.8792398 5.5142874E-10 400.0 800.0 CEBPD_8283 25695 cebpd 6 33 4.931041947514644 0.001064229949277462 0.04660337196487119 -1.7448534 1.7448534 1.5112764 1.1808562 -1.1091306 1.1632857 -1.2394414 -1.7448534 0.058942504 0.4230822 0.5723006 0.4002271 0.25125074 0.0013492391 FOXO3_8662 294515 foxo3 6 33 5.4999669057010445 4.892622935290802E-4 0.024244234176717318 -1.2566216 1.2566216 1.0614622 1.1601709 -1.079766 1.2351261 -1.0818822 -1.2566216 0.5805516 0.006729694 0.39392698 0.05156713 0.36525682 0.009231823 RACGAP1_9647 315298 racgap1 6 33 4.975487004081924 0.0010004151170830422 0.04485194441588972 -1.9561311 1.9561311 -1.3192348 -1.1578026 -1.3200175 -1.3302816 -1.2755231 -1.9561311 0.0020764545 0.4090845 0.03817616 0.12314738 0.1474638 1.7993045E-6 COL6A1_33258 294337 col6a1 6 33 5.883938007323154 2.946332423358067E-4 0.0184931465106108 -1.2963793 1.2963793 1.0392392 1.087339 -1.0220999 1.0256748 -1.0175184 -1.2963793 0.45183122 0.03724682 0.7267819 0.7595603 0.7832794 4.8636808E-5 HMGB2_8808 29395 hmgb2 6 33 7.165868271034254 5.9555462551430516E-5 0.006230163110241315 -1.2237091 1.2237091 1.018338 1.0560277 -1.0056081 1.0553173 -1.0466622 -1.2237091 0.7025008 0.19168314 0.8820033 0.19782676 0.4032 6.503273E-5 CCNA2_8221 114494 ccna2 6 33 6.363817747299478 1.5928499826833864E-4 0.011997346069571266 -2.2779155 2.2779155 -1.2917906 1.0647689 -1.1779163 -1.2250353 -1.7099568 -2.2779155 0.21559504 0.712542 0.3548141 0.2945478 0.002165674 1.3289377E-4 400.0 800.0 CAR14_8195 791259 car14 6 33 5.622548741823349 4.155069777331821E-4 0.021733323307543944 1.3437802 1.3437802 -1.0729614 -1.0045716 -1.0374652 1.0918541 1.0406215 1.3437802 0.5479371 0.9352369 0.48226252 0.07171779 0.37152052 1.9879693E-4 CKAP2_8324 306575 ckap2 6 33 5.5085591162589935 4.8366838460889294E-4 0.024244234176717318 -1.60344 1.60344 1.2230787 1.3910154 1.1549793 1.0492792 -1.2909145 -1.60344 0.33479646 0.03827186 0.28118697 0.73790425 0.11704442 0.0014959279 KIF18B_32882 303575 kif18b 6 33 8.729846435600301 1.0096282801241863E-5 0.001462407731902956 -2.8196726 2.8196726 -1.2782735 -1.1874315 -1.3400906 -1.36967 -1.7469984 -2.8196726 0.054131947 0.32641783 0.08709592 0.15354994 0.011877427 2.8896105E-4 400.0 800.0 LRRC17_32500 502715 lrrc17 6 33 6.427974943654503 1.4693721054293007E-4 0.011546773139703403 1.4362291 1.4362291 1.0337524 1.0702205 1.0107937 -1.2973351 -1.0079873 1.4362291 0.70403343 0.40989634 0.88608694 0.088742405 0.9334158 3.4403532E-5 ORM1_9400 24614 orm1 6 33 6.089045439805113 2.2595730094487898E-4 0.016364522987661813 2.2859752 2.2859752 1.0208805 -1.3109647 -1.5326533 -1.1922714 -1.1650075 2.2859752 0.91853875 0.1880169 0.036662813 0.4469726 0.40155178 0.011845734 400.0 800.0 BNIP3_8154 84480 bnip3 6 33 7.585825603009371 3.632639529738135E-5 0.004023682490880535 1.4182588 1.4182588 1.1022321 -1.0244379 -1.0026033 1.2436466 1.056242 1.4182588 0.12892336 0.6861376 0.97487366 3.9913043E-4 0.37147793 0.0026236714 LOC680097_9132 6 33 6.5501324600935575 1.2613457422594454E-4 0.010795972875793343 -1.2769636 1.2769636 1.0904237 1.074681 -1.035045 -1.1185063 -1.1145838 -1.2769636 0.16124232 0.34685236 0.5591435 0.1227059 0.03395131 6.261985E-5 CCNB2_8223 100364016;363088 ccnb2-ps2;ccnb2 6 33 5.650058145777095 4.0062380898198136E-4 0.021553560923230596 -2.2866728 2.2866728 -1.459381 1.0410427 1.2052076 -1.4410747 -1.7335143 -2.2866728 0.11434125 0.8346297 0.33237717 0.13259278 0.018071055 4.4390542E-4 400.0 800.0 COL5A3_32780 60379 col5a3 6 33 31.813216021796297 2.2881696537524476E-12 2.1543117290079294E-9 -3.9044185 3.9044185 -1.049321 1.1051947 -1.1082721 -1.0749389 -1.4138122 -3.9044185 0.61146116 0.2004093 0.36168668 0.35234413 0.10163476 8.5610645E-6 400.0 800.0 HTRA1_8856 65164 htra1 6 33 8.163800474588616 1.8802639272341715E-5 0.0023603579833212968 -1.2142067 1.2142067 1.0547391 1.1189715 -1.0512035 1.0136424 -1.0277421 -1.2142067 0.21532634 0.0061105583 0.42789868 0.7454491 0.5141105 1.45487575E-5 FKBP14_8647 362366 fkbp14 6 33 6.42670938090247 1.471707675798628E-4 0.011546773139703403 1.2409477 1.2409477 1.082276 1.0501568 1.018441 1.0244551 1.0989618 1.2409477 0.16172874 0.27575973 0.6790972 0.3297083 0.008396827 7.1214505E-5 SH3BP5_9823 117186 sh3bp5 6 33 6.945586254552216 7.761814365125907E-5 0.007692366552385308 -1.3120978 1.3120978 -1.0007294 1.057516 1.0495961 1.0453056 -1.1514647 -1.3120978 0.99374866 0.28173354 0.38741666 0.36194983 0.032704685 2.9332075E-5 HIST2H3C2_32796 310678 hist2h3c2 6 33 7.703595289169821 3.170095448934429E-5 0.003730806081464706 -1.6335101 1.6335101 -1.0557843 -1.0445789 -1.0876018 -1.1503798 -1.3075323 -1.6335101 0.59950703 0.41388488 0.21849634 0.18253972 0.010018534 4.3094237E-4 TAX1BP3_32829 360564 tax1bp3 6 33 6.010360654750275 2.5006150537154603E-4 0.01681663623623647 -1.3304518 1.3304518 -1.0078024 1.015754 -1.0910547 -1.0571326 -1.1106412 -1.3304518 0.8892874 0.8137488 0.11990243 0.4383532 0.014766097 2.1669424E-5