One-way ANOVA Data Source: rat_4D_KI_No0 Work Source: null BMDExpress3 Version: BMDExpress 3.20.0129 BETA Timestamp (Start Time): 08/14/2025 10:45.27 Adjusted P-Value Cutoff: 0.05 Multiple Testing Correction: true Filter Out Control Genes: true NOTEL/LOTEL Test: T-Test NOTEL/LOTEL p-Value Threshold: 0.05 NOTEL/LOTEL Fold Change Threshold: 2.0 Total Run Time: 0 seconds Chip: BioSpyder S1500_Rat Provider: BioSpyder Chip File Creation Date: 10/31/24 Log Transformation: BASE2 BMDExpress3 Version: BMDExpress 3.20.0119 BETA Timestamp: 04/30/2025 12:12.19 Probe ID Gene ID Gene Symbol Df1 Df2 F-Value Unadjusted P-Value Adjusted P-Value Max Fold Change Max Fold Change Unsigned FC Dose Level 1 FC Dose Level 2 FC Dose Level 3 FC Dose Level 4 FC Dose Level 5 FC Dose Level 6 NOTEL/LOTEL T-Test p-Value Level 1 NOTEL/LOTEL T-Test p-Value Level 2 NOTEL/LOTEL T-Test p-Value Level 3 NOTEL/LOTEL T-Test p-Value Level 4 NOTEL/LOTEL T-Test p-Value Level 5 NOTEL/LOTEL T-Test p-Value Level 6 NOTEL LOTEL NDRG1_32364 299923 ndrg1 6 32 37.49816049104679 3.9812597663058114E-13 2.7072566410879517E-10 -2.7716427 2.7716427 -1.06123 -1.0352411 -1.1074032 -1.0660616 -1.2355186 -2.7716427 0.5604782 0.6551876 0.2488065 0.38735145 0.0021830692 3.557608E-7 400.0 800.0 DBP_8439 24309 dbp 6 32 67.10618057897409 1.1102230246251565E-16 1.1324274851176597E-13 8.080792 8.080792 1.0066063 1.0607418 -1.0044826 1.0054891 1.6696016 8.080792 0.930667 0.54532576 0.9638004 0.9716742 0.02746203 1.0320055E-12 400.0 800.0 KIF22_8963 293502 kif22 6 32 6.538595094872249 1.405309610996719E-4 0.012464485245362202 -1.9441775 1.9441775 -1.2462778 -1.1095773 -1.1918129 -1.303512 -1.6433281 -1.9441775 0.26831615 0.34333885 0.09820165 0.10996006 0.0010780371 7.860058E-4 ARNTL_8086 29657 bmal1 6 32 65.40061499826106 1.1102230246251565E-16 1.1324274851176597E-13 -9.850628 9.850628 1.0799955 -1.0775225 1.0670751 1.0138208 -1.6926208 -9.850628 0.6580855 0.50165284 0.5732757 0.90153795 0.013973202 2.3048717E-7 400.0 800.0 CYP24A1_32574 25279 cyp24a1 6 32 7.966666489954423 2.6545886673723373E-5 0.003610240587626379 2.6864655 2.6864655 1.0721403 1.33328 1.60049 -1.0546058 1.3174748 2.6864655 0.55001813 0.036983076 8.421412E-4 0.73474544 0.073973686 0.014155019 400.0 800.0 SREBF1_32750 78968 srebf1 6 32 5.872416468027313 3.2401565259387866E-4 0.024481182640426386 1.8960773 1.8960773 1.0231731 1.0716002 1.3205222 1.5880755 1.2678747 1.8960773 0.89640224 0.40116268 0.19699259 0.008636655 0.041334897 4.0949784E-5 ACY3_32489 293653 acy3 6 32 7.31498512542154 5.567182933807757E-5 0.00709815824060489 1.4375366 1.4375366 -1.052678 -1.0075955 -1.0612531 1.0435644 -1.0792195 1.4375366 0.41345954 0.89751333 0.5285037 0.63086385 0.15757383 3.531991E-4 NFIL3_9304 114519 nfil3 6 32 8.673626896535334 1.2308769658520013E-5 0.0017935635788129162 -2.9010816 2.9010816 1.0374942 1.0329233 -1.1340421 -1.1767863 -1.3637419 -2.9010816 0.84139526 0.8273195 0.5656379 0.34975427 0.09661599 1.0055404E-5 400.0 800.0 HSPA8_8845 688655;688932;689955;680121;24468 hspa8-ps22;hspa8-ps23;hspa8-ps25;haus8l2;hspa8 6 32 7.2013760464454135 6.355594486995297E-5 0.007626713384394357 1.4182578 1.4182578 1.0434885 1.0485237 1.0430458 1.1104027 1.2668449 1.4182578 0.6416653 0.43751684 0.5086723 0.13488528 0.0056820987 8.481731E-6 CYP1A1_8415 24296 cyp1a1 6 32 8.730869989539906 1.1583535592607497E-5 0.0017935635788129162 2.7368894 2.7368894 -1.265376 -1.1167902 -1.1626288 -1.1763521 -1.2923541 2.7368894 0.05059779 0.4132151 0.39518613 0.55374724 0.16412671 0.0025901769 400.0 800.0 CD74_8252 25599 cd74 6 32 6.827890128513063 9.895039126239791E-5 0.010624147272383776 -1.4943808 1.4943808 1.2144548 1.1512022 1.0720296 1.0697027 1.0436865 -1.4943808 0.016110724 0.03596486 0.3284267 0.59018064 0.68334186 0.012023656 NR1D2_9358 259241 nr1d2 6 32 17.16483272780404 9.186678529005121E-9 3.7481648398340894E-6 2.9973326 2.9973326 1.0262618 1.1759286 1.2164694 1.1957576 1.5516758 2.9973326 0.8204226 0.21799538 0.10118614 0.20381014 0.010136764 8.4081677E-7 400.0 800.0 EMR1_8558 316137 adgre1 6 32 5.788911420078057 3.6079549753820217E-4 0.025380097068204568 -1.9115049 1.9115049 1.0495867 -1.0928317 -1.0360346 -1.065561 -1.3755857 -1.9115049 0.36235836 0.51920384 0.69752747 0.75422114 0.08843905 1.0016566E-6 NPAS2_9350 316351 npas2 6 32 34.48153745977078 1.255662240851052E-12 6.403877428340365E-10 -6.697609 6.697609 1.1712773 -1.0358667 1.1788393 -1.1829884 -1.5309353 -6.697609 0.21077724 0.72803926 0.17245471 0.1443381 0.12892382 6.037651E-5 400.0 800.0 CYP4A2_32530 24306;298423 cyp4a2;cyp4a3 6 32 9.281855701433244 6.527490409302672E-6 0.001331608043497745 2.3881662 2.3881662 1.0854388 1.1827589 1.1504209 1.1025152 1.814744 2.3881662 0.60905766 0.2951791 0.24500541 0.42091507 0.003240268 7.7340554E-4 400.0 800.0 PPARD_9536 25682 ppard 6 32 12.801957915441141 2.506294635162831E-7 7.304058651045966E-5 -2.274894 2.274894 -1.0677077 -1.0671896 1.0380834 1.0398043 -1.3718461 -2.274894 0.56363463 0.6170017 0.74222726 0.7238638 0.03798776 1.652394E-7 400.0 800.0 PLTP_32412 296371 pltp 6 32 5.210832345911133 7.731954106792172E-4 0.049291207430800094 -1.6245043 1.6245043 -1.2807646 -1.3374957 -1.0759221 -1.1469994 -1.4944066 -1.6245043 0.023496008 0.020661963 0.44852984 0.24261145 0.009735303 0.0010555462 EHHADH_8534 171142 ehhadh 6 32 6.730053840341136 1.1132709956840348E-4 0.010814632529502053 2.1117656 2.1117656 -1.114393 1.1374397 1.053738 1.2146667 1.3434161 2.1117656 0.62701666 0.23489788 0.66484666 0.23383169 0.07444724 2.2485747E-5 400.0 800.0 FADS1_8593 84575 fads1 6 32 5.389238457151839 6.090566212166859E-4 0.04007985507361417 1.5844251 1.5844251 -1.2252469 -1.0356529 1.0541985 -1.0457731 1.2376201 1.5844251 0.41078427 0.77812487 0.5654345 0.5571481 0.00873018 0.001733743 APCS_8057 29339 apcs 6 32 5.822820349086712 3.4535525263557076E-4 0.02516159697773444 -1.8477815 1.8477815 -1.203096 -1.1637961 1.0304183 -1.1110239 -1.3427497 -1.8477815 0.2567905 0.13546418 0.78302354 0.35416606 0.110301785 1.3294408E-5 VAV1_33194 25156 vav1 6 32 5.549442925090821 4.928616977155631E-4 0.03351459544465829 -1.7300994 1.7300994 1.0065547 1.0661765 -1.061559 1.084128 1.0158242 -1.7300994 0.9490231 0.5230989 0.6014723 0.489017 0.8964611 0.010397833 PTPRK_9622 360302 ptprk 6 32 5.895736111358219 3.1446727675987773E-4 0.024481182640426386 -1.2505586 1.2505586 -1.027264 1.0044454 1.0149187 1.048358 -1.1301547 -1.2505586 0.7794535 0.8808081 0.71989626 0.28642753 0.06933998 4.193903E-4 SULT1C2_33309 171072;316153 sult1c2;sult1c2a 6 32 7.111403334489473 7.063580178168216E-5 0.008005390868590645 -1.7735114 1.7735114 -1.1092938 1.001494 -1.0309793 -1.1410484 -1.2332399 -1.7735114 0.24887396 0.98423094 0.5955587 0.053362418 0.2973383 4.4114586E-7 CYP4A2_8426 24306;298423 cyp4a2;cyp4a3 6 32 9.447418710923028 5.514848188004073E-6 0.00125003225594759 4.212644 4.212644 1.402458 1.5270303 1.5660081 1.4483464 3.2187672 4.212644 0.20423552 0.077108674 0.04980045 0.13471341 2.3020901E-4 0.0017568707 150.0 400.0 CLIC4_8332 83718 clic4 6 32 8.758684115809402 1.1247620456455998E-5 0.0017935635788129162 -1.2052774 1.2052774 -1.0001428 1.0194615 -1.0113885 -1.0048738 -1.0576016 -1.2052774 0.99602574 0.47600707 0.63390934 0.88957536 0.18569274 1.6103296E-4 GLUL_32832 24957 glul 6 32 6.125554185207703 2.347993088899214E-4 0.01995794125564332 1.2722621 1.2722621 -1.0820739 1.0341789 -1.0884876 -1.0118333 -1.0628551 1.2722621 0.38712686 0.54380035 0.17731716 0.8676293 0.13178164 1.1137037E-4 VNN1_10157 29142 vnn1 6 32 10.533267729425342 1.9006510354468986E-6 4.8466601403895915E-4 2.2377195 2.2377195 -1.0374844 -1.0016494 1.0114841 1.1813539 1.3015432 2.2377195 0.6789063 0.9809039 0.9368286 0.1997755 0.1423494 2.1007775E-4 400.0 800.0 CYP4A2_8425 24306 cyp4a2 6 32 9.068253866742227 8.134015948790818E-6 0.0015084902305030244 3.7580764 3.7580764 1.0414362 1.1562735 1.251349 1.3875091 2.4668105 3.7580764 0.803856 0.4933147 0.3457985 0.21541636 0.0037612417 2.8765342E-5 150.0 400.0 MAP7_9184 293016 map7 6 32 5.99135210709404 2.7831460971416977E-4 0.022710472152676252 1.2135624 1.2135624 -1.0850666 -1.0048685 -1.0915506 1.0165772 -1.039123 1.2135624 0.19081622 0.9059513 0.1284917 0.7401614 0.4842362 3.4981276E-4 HMGCS2_8812 24450 hmgcs2 6 32 13.594439923532011 1.305015606689608E-7 4.437053062744667E-5 4.8578043 4.8578043 -1.0958458 -1.1133467 1.0879067 1.2932 1.3349072 4.8578043 0.63653445 0.32382688 0.50184727 0.2714468 0.403679 2.4687411E-5 400.0 800.0 ACAA1A_7954 24157;501072 acaa1a;acaa1b 6 32 6.745841577224101 1.0922399873369848E-4 0.010814632529502053 1.7569838 1.7569838 -1.1089225 1.0147725 1.0151173 1.1026158 1.2027671 1.7569838 0.23120147 0.85243565 0.85808545 0.52053183 0.22918196 2.8711934E-6 CML3_32841 113892 nat8f3 6 32 6.605764420290866 1.294568201886115E-4 0.012004177872034883 1.992896 1.992896 -1.1006896 1.1286732 1.0701342 -1.1962761 1.0175678 1.992896 0.5250353 0.4186893 0.62204725 0.15666841 0.92230135 3.887538E-5