One-way ANOVA Data Source: rat_4D_LU_No0 Work Source: null BMDExpress3 Version: BMDExpress 3.20.0129 BETA Timestamp (Start Time): 08/14/2025 10:45.28 Adjusted P-Value Cutoff: 0.05 Multiple Testing Correction: true Filter Out Control Genes: true NOTEL/LOTEL Test: T-Test NOTEL/LOTEL p-Value Threshold: 0.05 NOTEL/LOTEL Fold Change Threshold: 2.0 Total Run Time: 0 seconds Chip: BioSpyder S1500_Rat Provider: BioSpyder Chip File Creation Date: 10/31/24 Log Transformation: BASE2 BMDExpress3 Version: BMDExpress 3.20.0119 BETA Timestamp: 04/30/2025 12:12.19 Probe ID Gene ID Gene Symbol Df1 Df2 F-Value Unadjusted P-Value Adjusted P-Value Max Fold Change Max Fold Change Unsigned FC Dose Level 1 FC Dose Level 2 FC Dose Level 3 FC Dose Level 4 FC Dose Level 5 FC Dose Level 6 NOTEL/LOTEL T-Test p-Value Level 1 NOTEL/LOTEL T-Test p-Value Level 2 NOTEL/LOTEL T-Test p-Value Level 3 NOTEL/LOTEL T-Test p-Value Level 4 NOTEL/LOTEL T-Test p-Value Level 5 NOTEL/LOTEL T-Test p-Value Level 6 NOTEL LOTEL FBXO11_8619 301674 fbxo11 6 26 5.479210280806054 8.900093064488912E-4 0.04611372691927825 -1.279844 1.279844 -1.1464456 -1.0597318 -1.0236472 -1.096479 -1.2039887 -1.279844 0.16771784 0.22411914 0.55659884 0.06056293 0.076989636 1.766576E-4 DBP_8439 24309 dbp 6 26 124.01501572521146 1.1102230246251565E-16 1.170175067954915E-13 14.498324 14.498324 -1.0580992 -1.0397253 -1.1193444 -1.030167 1.2530718 14.498324 0.32498965 0.5951124 0.14348988 0.82718956 0.5413758 3.8986766E-8 400.0 800.0 SLC2A1_9862 24778 slc2a1 6 26 6.599155183582575 2.504009611543623E-4 0.022949792439712857 -1.5381069 1.5381069 -1.2610664 -1.0382956 -1.0746143 -1.1461588 -1.5381069 -1.231716 0.01396225 0.5687966 0.23151125 0.07644649 0.0029857717 0.03782965 ARNTL_8086 29657 bmal1 6 26 47.1280961512161 9.550138457825597E-13 6.710563956365453E-10 -7.645294 7.645294 -1.2214361 -1.2394799 -1.1855855 -1.0163229 -1.4535934 -7.645294 0.30519345 0.13952787 0.20366096 0.9159605 0.013685481 1.30417E-7 400.0 800.0 SKP1_9831 287280 skp1 6 26 7.2364497274915935 1.2766201724379034E-4 0.01416376486052158 -1.1391169 1.1391169 -1.0025443 1.0321007 1.0337702 1.0045038 -1.0940168 -1.1391169 0.9209638 0.3055602 0.37998238 0.9068292 0.012738114 4.1202852E-4 ADM_33168 25026 adm 6 26 5.798371931987071 6.128964403431247E-4 0.03915108170434264 -2.0922813 2.0922813 -1.4750621 -1.2933356 -1.1532979 -1.3588616 -1.1402684 -2.0922813 0.01084957 0.0663287 0.3161642 0.14461073 0.5813401 1.10892266E-4 400.0 800.0 LPL_32544 24539 lpl 6 26 5.481259707955409 8.878524577161651E-4 0.04611372691927825 -1.5022548 1.5022548 -1.1657113 -1.0325115 -1.0600681 1.0186827 -1.2337304 -1.5022548 0.3754112 0.67258525 0.4397228 0.77890867 0.004874068 3.550824E-4 MET_9220 24553 met 6 26 8.933432340336575 2.457221800011844E-5 0.004642270985394444 -1.7313224 1.7313224 -1.1030321 -1.1184708 -1.09797 -1.0031986 -1.1858344 -1.7313224 0.2703947 0.24689806 0.32167518 0.9773529 0.11445168 8.8184446E-5 ECH1_8516 64526 ech1 6 26 6.381788029189216 3.175026312264295E-4 0.02390341237947548 -1.2489823 1.2489823 1.2182628 1.210938 1.1135569 1.0631566 1.0482271 -1.2489823 0.0027571726 0.019864582 0.14690588 0.61154103 0.6369247 0.0029804993 ERO1LB_32533 364755 ero1b 6 26 5.443078469089825 9.289691101381781E-4 0.04662540200407808 -1.4196491 1.4196491 1.0555314 -1.176895 -1.0337589 1.0480323 -1.2095492 -1.4196491 0.42502883 0.04715269 0.6121144 0.56842506 0.261082 0.00926183 NR1D2_9358 259241 nr1d2 6 26 19.912903987750845 1.3866474080082014E-8 7.3076318402032214E-6 3.9713178 3.9713178 -1.0909324 1.0606545 -1.048268 1.1150879 1.378611 3.9713178 0.5937645 0.6316825 0.78588283 0.4710619 0.3546363 4.1727995E-7 400.0 800.0 ECI2_8521 291075 eci2 6 26 16.99969203762133 6.930506046831653E-8 2.9219013493442247E-5 -1.5478029 1.5478029 1.0085121 1.0139068 -1.0086602 1.0039887 -1.1379206 -1.5478029 0.8514394 0.837721 0.7977558 0.96188074 0.12917432 4.6710566E-6 RAP1GAP_9659 313644 rap1gap 6 26 11.727940766484172 2.3686205535833338E-6 5.547835696615186E-4 -2.0497074 2.0497074 -1.0810008 -1.014803 -1.0800737 -1.0338497 -1.1243095 -2.0497074 0.42365268 0.81516033 0.4716755 0.787766 0.45348623 1.2927986E-4 400.0 800.0 NPAS2_9350 316351 npas2 6 26 158.67856564665507 0.0 0.0 -3.878833 3.878833 1.0260739 1.0397627 1.0260329 1.0409982 -1.1579531 -3.878833 0.49705517 0.37001806 0.5436915 0.30834398 0.24999693 1.898828E-6 400.0 800.0 SUOX_9974 81805 suox 6 26 11.93916757798451 2.0159588766111014E-6 5.312051639870252E-4 -1.4577416 1.4577416 -1.0812217 1.0778769 -1.0294994 -1.0652565 -1.023608 -1.4577416 0.33644646 0.17665339 0.54784817 0.37058884 0.52200806 1.4617677E-4 CCNA2_8221 114494 ccna2 6 26 5.820840745249257 5.972257994083519E-4 0.03915108170434264 -1.7335578 1.7335578 -1.1449249 -1.0474805 1.0645103 -1.1297824 -1.3572246 -1.7335578 0.25365275 0.77076507 0.63332427 0.27621615 0.134736 1.5184063E-5 SYTL2_32351 361604 sytl2 6 26 8.695044609735888 3.061199599541098E-5 0.004642270985394444 -1.531746 1.531746 -1.047444 -1.0777814 -1.0156096 -1.0049309 1.000897 -1.531746 0.61321527 0.1743554 0.77361935 0.9555349 0.99470663 3.2360808E-6 KIF20B_8962 309523 kif20b 6 26 8.687376049769885 3.0831021724631036E-5 0.004642270985394444 -1.8564057 1.8564057 -1.1836284 1.0041513 -1.0767576 -1.458113 -1.1700894 -1.8564057 0.053838816 0.980196 0.42170414 0.02376958 0.16016787 2.0663249E-5 CPQ_33239 58952 cpq 6 26 8.138754418108178 5.185976588117924E-5 0.006832524154845365 -1.3296798 1.3296798 1.0433557 1.0677631 1.0248473 1.108113 -1.0119058 -1.3296798 0.6483904 0.18510692 0.6749967 0.0790312 0.8948915 8.9507565E-5 LOC102549726_32764 102549726 loc102549726 6 26 6.503561177623753 2.7782264919318234E-4 0.023426005779969134 -1.2561013 1.2561013 1.002302 -1.0015792 -1.0259742 -1.0214659 -1.0863081 -1.2561013 0.97197413 0.9766947 0.39487302 0.56647813 0.096134745 7.7193906E-4 G0S2_32729 289388 g0s2 6 26 6.679644960513942 2.295585361651309E-4 0.022949792439712857 -1.6299958 1.6299958 1.0882998 1.034211 1.0427669 1.0067044 -1.0996584 -1.6299958 0.6323326 0.5768431 0.5243909 0.9552327 0.56866443 2.0829828E-5 CCNB2_8223 100364016;363088 ccnb2-ps2;ccnb2 6 26 6.386850356080486 3.1573738532408857E-4 0.02390341237947548 -1.9276227 1.9276227 -1.0732218 1.045233 1.0560755 1.0553089 -1.111255 -1.9276227 0.64436144 0.7424769 0.6398157 0.67512256 0.6260398 0.001388838 PTGS1_32494 24693 ptgs1 6 26 5.472699243381886 8.96898863230744E-4 0.04611372691927825 -1.3796962 1.3796962 -1.0815798 1.0246671 -1.1217309 1.0530058 -1.1123922 -1.3796962 0.40768057 0.7373765 0.12542868 0.3886717 0.26301947 0.0047746976 ST6GALNAC2_9951 303692 st6galnac2 6 26 7.404321980008693 1.074740921707118E-4 0.012586410349770026 -1.6302238 1.6302238 -1.1043037 -1.0042373 -1.0794202 -1.1456232 -1.4499135 -1.6302238 0.30829418 0.97099835 0.34890872 0.3414377 0.003449329 1.3542067E-5 IGFBP7_32929 289560 igfbp7 6 26 6.0791394832726215 4.449087594297074E-4 0.03126225549592744 -1.2649688 1.2649688 -1.0474083 -1.0268179 1.0374641 1.0489305 -1.0919821 -1.2649688 0.6091104 0.49956053 0.33878404 0.39827546 0.08358323 7.9404074E-4 ECHS1_8519 140547 echs1 6 26 12.155045847183109 1.7131432781258837E-6 5.15900861469909E-4 -1.1817062 1.1817062 -1.0096931 1.0073972 1.0168723 1.0215095 -1.1257697 -1.1817062 0.7704279 0.82213616 0.41065907 0.4675584 0.015343679 3.3809867E-4 FAM69A_8605 360906 dipk1a 6 26 6.634766750662607 2.4093971543170944E-4 0.022949792439712857 -1.6609838 1.6609838 -1.0001656 -1.0903193 -1.0057031 1.0445848 -1.1969391 -1.6609838 0.9992653 0.23824549 0.92615515 0.659854 0.33191538 3.9119423E-6 PIK3R1_32562 25513 pik3r1 6 26 5.489683885877874 8.790452274189953E-4 0.04611372691927825 -1.5886097 1.5886097 -1.0718807 1.035209 -1.0555426 -1.0046592 -1.2033565 -1.5886097 0.6571881 0.69634044 0.3921375 0.9633172 0.3121889 1.3102693E-4 FGG_8639 24367 fgg 6 26 10.440558086366444 6.615893288874908E-6 0.0013946303052948307 -1.6731526 1.6731526 1.1677713 1.2204471 1.2635046 1.1143595 1.0797304 -1.6731526 0.22387147 0.0016485499 0.064696826 0.2639933 0.77130497 6.5173504E-7 LOC686151_32901 686151;684771 cdca5l1;cdca5 6 26 6.462749507646346 2.9049450842721924E-4 0.023552400914022237 -1.8206285 1.8206285 -1.0672095 -1.012024 1.0039726 1.0413921 -1.2835747 -1.8206285 0.5663916 0.8918031 0.9797591 0.7297344 0.01615665 0.0011492469 DDIT4_8450 140942 ddit4 6 26 5.702027566260006 6.852537710112516E-4 0.041243028941682996 -2.0645292 2.0645292 1.3493943 -1.0333377 -1.2433175 -1.0146668 -2.0645292 -2.0357025 0.30201077 0.90512246 0.2529321 0.9320141 0.009849776 3.7399319E-4 150.0 400.0 ACSS1_32386 296259 acss1 6 26 6.796231680831587 2.0259924003818153E-4 0.02135395990002433 -1.5329971 1.5329971 -1.0443974 1.0006368 -1.062631 1.0307003 -1.1285635 -1.5329971 0.62040097 0.9928019 0.4126602 0.60542667 0.46211573 8.2437845E-4 HGF_32812 24446 hgf 6 26 14.05035169431857 4.444922538926477E-7 1.5616494520095023E-4 -1.7001215 1.7001215 -1.1336969 -1.0097706 -1.1135054 -1.1041175 -1.164869 -1.7001215 0.28785095 0.81368124 0.028958874 0.08080707 0.30336773 5.867185E-5 MCL1_9205 60430 mcl1 6 26 6.132082620360735 4.191656553902412E-4 0.030469006950435463 -1.4682583 1.4682583 1.0401388 1.0170746 1.0200217 -1.0750008 -1.1579711 -1.4682583 0.6903028 0.88739055 0.72511655 0.4510057 0.025493344 3.441423E-4 DHRS3_8468 313689 dhrs3 6 26 6.521430212457197 2.7246196470176454E-4 0.023426005779969134 -1.4523875 1.4523875 -1.0363144 1.0066888 1.0213292 -1.0244182 -1.134534 -1.4523875 0.64060616 0.91441447 0.7211659 0.70435417 0.4504468 7.226704E-4 CEBPB_8282 24253 cebpb 6 26 5.717829369847315 6.727857136006321E-4 0.041243028941682996 -1.378042 1.378042 1.1658323 1.11551 1.044336 1.0161774 -1.0577931 -1.378042 0.23934543 0.22824837 0.6231743 0.79227066 0.63168544 6.3027715E-4 HMGCS2_8812 24450 hmgcs2 6 26 8.177349735038979 4.9963982924894346E-5 0.006832524154845365 -2.0852132 2.0852132 -1.0226398 1.0452234 -1.0233499 1.0668153 -1.2220811 -2.0852132 0.79138416 0.72359806 0.8331687 0.769453 0.32330567 4.937762E-5 400.0 800.0 BNIP3L_8155 140923 bnip3l 6 26 5.4053290626652055 9.71627346784909E-4 0.04763233597726949 -1.1783965 1.1783965 -1.0560396 -1.0140308 -1.0098294 -1.0109227 -1.0720034 -1.1783965 0.2970284 0.7574232 0.71180505 0.79194576 0.053582475 1.6799886E-5 PRKCD_9567 170538 prkcd 6 26 7.699568916088463 7.980850487787627E-5 0.009896254604856658 -1.4240495 1.4240495 -1.02608 1.0275462 -1.0129883 -1.0815966 -1.084051 -1.4240495 0.75514054 0.6727947 0.8347505 0.21301255 0.21417947 1.9296915E-4 ALOX15_8036 81639 alox15 6 26 5.678423906010799 7.043401527042636E-4 0.041243028941682996 1.5158014 1.5158014 1.0611138 1.367309 1.2677405 -1.0682602 -1.1360606 1.5158014 0.5822408 0.0672024 0.019030917 0.36371762 0.49436754 0.0065615047 DRAM2_33198 362011 dram2 6 26 5.584160216602203 7.864267068086184E-4 0.04480506751223155 -1.2274764 1.2274764 -1.0811459 -1.0585612 -1.0130875 -1.0120506 -1.0957545 -1.2274764 0.21126124 0.09848068 0.6664106 0.62943953 0.0705565 0.0111872135 LOC100912247_9104 100912216 prcd 6 26 8.73593861809419 2.9471869579911214E-5 0.004642270985394444 -1.5206058 1.5206058 -1.0057975 1.040461 -1.0155532 -1.1245543 -1.3519135 -1.5206058 0.9570736 0.6211449 0.78550494 0.1778839 0.012699043 6.1536557E-4 S100A4_9772 24615 s100a4 6 26 5.959298365690279 5.096459867017789E-4 0.03465592709572096 1.582087 1.582087 -1.104787 1.0483427 -1.0449705 -1.0010284 -1.0166517 1.582087 0.2762203 0.53702354 0.66199034 0.9912317 0.82827365 0.013634568