One-way ANOVA Data Source: rat_4D_OV_No0 Work Source: null BMDExpress3 Version: BMDExpress 3.20.0129 BETA Timestamp (Start Time): 08/14/2025 10:45.28 Adjusted P-Value Cutoff: 0.05 Multiple Testing Correction: true Filter Out Control Genes: true NOTEL/LOTEL Test: T-Test NOTEL/LOTEL p-Value Threshold: 0.05 NOTEL/LOTEL Fold Change Threshold: 2.0 Total Run Time: 0 seconds Chip: BioSpyder S1500_Rat Provider: BioSpyder Chip File Creation Date: 10/31/24 Log Transformation: BASE2 BMDExpress3 Version: BMDExpress 3.20.0119 BETA Timestamp: 04/30/2025 12:12.19 Probe ID Gene ID Gene Symbol Df1 Df2 F-Value Unadjusted P-Value Adjusted P-Value Max Fold Change Max Fold Change Unsigned FC Dose Level 1 FC Dose Level 2 FC Dose Level 3 FC Dose Level 4 FC Dose Level 5 FC Dose Level 6 NOTEL/LOTEL T-Test p-Value Level 1 NOTEL/LOTEL T-Test p-Value Level 2 NOTEL/LOTEL T-Test p-Value Level 3 NOTEL/LOTEL T-Test p-Value Level 4 NOTEL/LOTEL T-Test p-Value Level 5 NOTEL/LOTEL T-Test p-Value Level 6 NOTEL LOTEL CYR61_32555 83476 ccn1 6 33 5.033310205499552 9.233513921343972E-4 0.03540094393994519 1.5756408 1.5756408 -1.4818407 -1.2595382 -1.5619907 -1.0688605 -1.2585336 1.5756408 0.036150854 0.23634462 0.0413867 0.7437636 0.16411747 0.0045304317 DBP_8439 24309 dbp 6 33 14.793510537547945 3.959370442618848E-8 2.8755126332195385E-5 3.7707567 3.7707567 1.2163488 1.040023 -1.0854475 1.105621 1.2969759 3.7707567 0.20710042 0.7763989 0.5129781 0.6488772 0.22338486 1.0962023E-7 400.0 800.0 PYGL_9632 64035 pygl 6 33 6.098322946029351 2.2328106962898886E-4 0.013748701014730465 1.4657089 1.4657089 1.0459722 -1.0907979 -1.0904144 1.0064932 -1.0625274 1.4657089 0.5149274 0.20373555 0.3074963 0.9358032 0.5141928 0.009782538 SLC27A1_33025 94172 slc27a1 6 33 5.568737417416688 4.4632864479920986E-4 0.02267349515579986 1.8175784 1.8175784 1.0735092 -1.1476272 -1.1248659 -1.1439456 -1.0756142 1.8175784 0.5601387 0.2804306 0.48681924 0.36845198 0.56077087 0.007014287 ARNTL_8086 29657 bmal1 6 33 4.781720888253251 0.001311829590005087 0.04369897912934978 -2.176714 2.176714 -1.1929687 -1.2087246 -1.0581093 -1.0178046 -1.0709649 -2.176714 0.4018397 0.13992393 0.7957814 0.8948775 0.62010694 7.3574274E-4 400.0 800.0 LOC102553917_33088 102548633;102551714 znf431l;zfp120l2 6 33 5.179265550270563 7.553022948676436E-4 0.030695485263421033 1.5165178 1.5165178 -1.0475676 -1.1028527 -1.1753881 1.0526863 -1.2473305 1.5165178 0.6378161 0.2668411 0.15572888 0.6032075 0.015459336 0.06971383 SKP1_9831 287280 skp1 6 33 4.892955467112094 0.0011223169972957026 0.03800913564174779 1.1074514 1.1074514 -1.0282437 -1.0413303 -1.0698668 -1.1010942 -1.0430155 1.1074514 0.40142035 0.39641577 0.11038579 0.007093771 0.31547078 0.004259041 OSTF1_33042 259275 ostf1 6 33 6.0749035693041575 2.3010197452333347E-4 0.013751976830335695 -1.5758975 1.5758975 1.0598363 -1.0266557 1.017304 1.0336957 -1.0542108 -1.5758975 0.43037653 0.73750335 0.8736736 0.74663067 0.46692428 0.0043087536 GSTA3_33275 494500;24421 gsta3;gsta1 6 33 5.315141842962785 6.276278326017293E-4 0.02772477730101552 1.6734116 1.6734116 1.2097147 -1.1711268 -1.0845342 -1.0576642 -1.3776863 1.6734116 0.07354151 0.1444051 0.4810333 0.69689965 0.23048633 0.0025209729 EI24_32946 300514 ei24 6 33 4.662560222355964 0.001552589132026716 0.0485363248658198 -1.7482148 1.7482148 1.1794711 -1.0825754 -1.0280533 -1.0136274 1.072021 -1.7482148 0.25897476 0.49856552 0.8420676 0.91021186 0.48313165 0.026933035 SDHB_9797 298596 sdhb 6 33 6.546167509681125 1.2675856258881346E-4 0.010626582888572322 1.7738913 1.7738913 1.0538435 1.102486 1.0586977 1.052843 -1.0265377 1.7738913 0.58117265 0.37920573 0.64683306 0.6137822 0.7922197 1.3715673E-4 ITPR2_8931 81678 itpr2 6 33 7.63868723963552 3.4167729721201745E-5 0.003654148778604313 1.7660873 1.7660873 -1.2202656 -1.3751627 -1.3583133 1.0367848 -1.275677 1.7660873 0.14592914 0.044521652 0.10213521 0.83351654 0.12747224 5.095769E-5 A2M_7932 24153 a2m 6 33 7.517263770831097 3.934308091202432E-5 0.0038069114482492104 5.1247716 5.1247716 -1.1173698 1.0434189 1.0149201 1.0877316 -1.2235773 5.1247716 0.71565694 0.88044876 0.9643481 0.77145433 0.38309917 0.0010780507 400.0 800.0 CTNNAL1_8399 298019 ctnnal1 6 33 5.269087454716892 6.681489982065525E-4 0.027880071001839483 1.4191825 1.4191825 1.0065311 1.0289457 -1.273526 -1.0843552 -1.0895325 1.4191825 0.94477457 0.7403785 0.16973403 0.26879343 0.29909095 0.0010260994 ADHFE1_7993 362474 adhfe1 6 33 6.454679703377985 1.4209899212835886E-4 0.010626582888572322 3.1216404 3.1216404 -1.0743049 1.0616817 1.0783995 -1.1924291 -1.0323251 3.1216404 0.74185055 0.79596144 0.7130678 0.47568882 0.88058716 0.0011137087 400.0 800.0 GRIN2B_32742 24410 grin2b 6 33 5.01292666938049 9.497799928719353E-4 0.03573986936140319 -2.340996 2.340996 1.1816214 1.0776163 1.215631 1.3615626 1.1122718 -2.340996 0.2955731 0.7573222 0.45438105 0.13087265 0.6079629 0.008902129 400.0 800.0 GNA11_8720 81662 gna11 6 33 6.43073451554902 1.4642929177166586E-4 0.010626582888572322 1.3665738 1.3665738 -1.0203247 -1.084789 1.0025605 1.0459926 -1.1158493 1.3665738 0.8011644 0.24033983 0.9633948 0.5177542 0.08243114 0.0058940407 EDEM1_8524 297504 edem1 6 33 5.502862350838801 4.87369661777981E-4 0.023552240258028507 1.3198605 1.3198605 1.0016172 -1.0645821 -1.1782407 -1.0517752 1.0185323 1.3198605 0.97920835 0.29397693 0.16594325 0.40023482 0.8251829 2.5167258E-4 HERPUD1_8795 85430 herpud1 6 33 4.918611846947224 0.0010828323215770208 0.03793647030076735 1.5318615 1.5318615 1.117861 -1.050771 -1.0055488 1.1639564 1.1833571 1.5318615 0.28902042 0.67037684 0.9590393 0.088306084 0.081152014 3.711429E-5 CXCL12_8410 24772 cxcl12 6 33 4.715347896412022 0.0014406655177328087 0.04646717987354075 1.6102247 1.6102247 -1.0927678 -1.3288965 -1.0250407 1.0630484 1.2548203 1.6102247 0.5564856 0.120374 0.8411701 0.61293936 0.24216369 1.0072792E-4 NR1D2_9358 259241 nr1d2 6 33 6.254797115527449 1.8284340477658922E-4 0.011985090274388042 1.9438163 1.9438163 1.0089235 1.0175494 -1.1495475 -1.0860593 -1.0342394 1.9438163 0.949493 0.88092685 0.3252518 0.5872537 0.8520651 2.114552E-5 GCDH_8693 364975 gcdh 6 33 11.218622102952816 8.319944923007583E-7 2.4151611547930583E-4 1.2762581 1.2762581 -1.0544721 1.0177714 -1.0363572 -1.1498742 -1.1181514 1.2762581 0.33112702 0.6753668 0.33315775 0.004010007 0.05253385 0.004091773 ECI2_8521 291075 eci2 6 33 6.006776015044598 2.512222073099979E-4 0.014585243578683306 1.2771764 1.2771764 1.001174 -1.0545774 -1.0218506 -1.039582 -1.056747 1.2771764 0.97855103 0.24562691 0.68404907 0.43820524 0.51187396 2.7942352E-4 MAPK14_9188 81649 mapk14 6 33 5.676295660101172 3.8695111238107316E-4 0.020691701588377385 1.2605789 1.2605789 1.0007846 1.0104173 -1.0153774 -1.0355858 -1.0723488 1.2605789 0.9899243 0.849457 0.75806236 0.49727574 0.20901549 6.210229E-4 HSD17B7_8834 29540 hsd17b7 6 33 15.83123795328601 1.7972895727247362E-8 2.8755126332195385E-5 8.618565 8.618565 1.0864029 1.0827286 1.0919363 1.1224793 -1.5735179 8.618565 0.745953 0.6868552 0.6693266 0.5032756 0.21643174 0.00193466 400.0 800.0 NPAS2_9350 316351 npas2 6 33 4.681203145283608 0.0015120536836848997 0.048007704456995565 -1.4362775 1.4362775 1.1221536 1.001558 1.0517057 -1.0566072 -1.0833279 -1.4362775 0.20351179 0.98922235 0.45229393 0.6472187 0.2518594 8.222469E-4 KDR_8956 25589 kdr 6 33 8.64901952301258 1.1018921614480703E-5 0.0018314974284317797 1.5417384 1.5417384 -1.1643673 -1.1544436 -1.2430955 -1.1257836 -1.1369143 1.5417384 0.07297293 0.1732304 0.04036314 0.3983533 0.14228661 0.0014463038 SUOX_9974 81805 suox 6 33 6.383250183149731 1.5543342074031408E-4 0.010891058998079938 1.6686085 1.6686085 -1.0799826 -1.1297268 -1.291325 -1.0514708 -1.1643823 1.6686085 0.56854266 0.23540282 0.07195266 0.6935086 0.21630768 0.006304265 ADRB2_7997 24176 adrb2 6 33 5.495466889225203 4.922191365138717E-4 0.023552240258028507 -2.0227056 2.0227056 -1.0182135 -1.1241326 1.0017344 -1.0063821 -1.1267697 -2.0227056 0.9058685 0.21264228 0.9934251 0.94897807 0.21094835 0.0046886643 400.0 800.0 CXCL12_32815 24772 cxcl12 6 33 5.047130047215157 9.058735008200536E-4 0.035398749108968244 1.6951698 1.6951698 -1.0400714 -1.1735318 1.0058713 -1.0322577 1.3365716 1.6951698 0.76254004 0.3028011 0.9589754 0.8414507 0.11796981 9.302236E-6 PRKAG1_33315 25520 prkag1 6 33 10.990581083057625 1.0306924200786938E-6 2.617958746999882E-4 1.4882486 1.4882486 1.0520196 -1.0579592 1.0446666 1.0253878 -1.0104817 1.4882486 0.3264005 0.43183535 0.51600826 0.611651 0.86646056 5.6801277E-6 NRP1_9366 246331 nrp1 6 33 14.70420742374329 4.245343454556405E-8 2.8755126332195385E-5 1.6678119 1.6678119 -1.0531485 -1.1640426 -1.1126496 -1.0351522 1.132615 1.6678119 0.4821094 0.122623876 0.109996624 0.7258392 0.09784008 5.1710745E-6 ELOVL5_8556 171400 elovl5 6 33 7.579823088969336 3.6580472007607945E-5 0.003716575955972967 1.5558335 1.5558335 -1.1393632 -1.2418882 -1.3688984 -1.0399292 -1.2837896 1.5558335 0.22461948 0.14552979 0.047239687 0.6976184 0.10258533 8.354124E-5 MXRA8_32384 313770 mxra8 6 33 9.866347908476385 3.086921029460399E-6 6.938225441286861E-4 -3.235216 3.235216 1.2904857 -1.026521 1.0381708 1.0260373 -1.0197364 -3.235216 0.20180613 0.8423241 0.7317047 0.8883175 0.8781183 0.014898227 400.0 800.0 TNFRSF12A_10049 302965 tnfrsf12a 6 33 6.478200585219769 1.3797674911153468E-4 0.010626582888572322 -4.4176507 4.4176507 -1.323606 1.0098267 -1.1604946 -1.1644721 -1.4527963 -4.4176507 0.2843905 0.9720946 0.6422129 0.49520487 0.07153661 0.002391042 400.0 800.0 JAK2_8935 24514 jak2 6 33 5.687142928067042 3.814428461130781E-4 0.020691701588377385 1.3020785 1.3020785 -1.1549684 -1.0854338 -1.1178263 1.0307664 -1.1129254 1.3020785 0.01642998 0.34416863 0.035510283 0.74897707 0.13999005 0.02812382 GOT1_8739 24401 got1 6 33 5.641168816964064 4.053707594718903E-4 0.021120855980689256 1.6339539 1.6339539 -1.0517571 -1.075642 -1.0321798 -1.0315714 -1.1401633 1.6339539 0.50106376 0.6255887 0.7870966 0.7262636 0.1881992 0.0066402582 SDPR_32765 316384 cavin2 6 33 4.952420524555883 0.001033016649432894 0.03793647030076735 1.4819647 1.4819647 -1.0590154 -1.0975143 -1.0997921 1.0341307 1.0388985 1.4819647 0.5196066 0.27697134 0.44288138 0.7023979 0.7090204 0.0016282779 CYP1B1_32710 25426 cyp1b1 6 33 5.365089698873848 5.865884555795731E-4 0.026487727594170944 2.2450686 2.2450686 -1.2259661 -1.663681 -1.0685692 1.2233715 -1.155535 2.2450686 0.15656224 0.0018087017 0.8116242 0.60114646 0.28122228 5.5620814E-4 400.0 800.0 ATP5L_33116 300677 atp5mg 6 33 4.751143057644391 0.0013696124923958664 0.04488794491207097 1.3774968 1.3774968 1.0207113 1.0578707 -1.0250889 1.0231739 -1.0447178 1.3774968 0.7915796 0.45632955 0.7137944 0.7755655 0.5673456 4.2080513E-4 VCAM1_32349 25361 vcam1 6 33 6.112840746482217 2.191600427148277E-4 0.013748701014730465 1.9397396 1.9397396 1.1307025 -1.2029612 -1.2033175 -1.1909142 -1.0259632 1.9397396 0.5623326 0.2381777 0.14748406 0.37391654 0.8081802 2.0158032E-4 ACAT2_7961 308100 acat2 6 33 5.486153263786723 4.98398784987808E-4 0.023552240258028507 2.4256186 2.4256186 1.4052178 1.1984949 1.7123789 1.3973169 1.1677134 2.4256186 0.043791253 0.24859805 0.019602604 0.055640917 0.32599473 0.0036786487 400.0 800.0 MAOB_9179 25750 maob 6 33 9.766554823644954 3.4144810242553447E-6 6.938225441286861E-4 2.15618 2.15618 -1.2274846 -1.179647 -1.2500974 -1.0520631 -1.0019294 2.15618 0.11148596 0.28557262 0.2504363 0.6507308 0.98364395 0.001417578 400.0 800.0 GADD45G_33229 291005 gadd45g 6 33 8.431958294292103 1.3966324747261005E-5 0.0018919714590956243 2.6208532 2.6208532 1.1483258 -1.2444686 1.0401484 1.036002 1.0714223 2.6208532 0.47947943 0.15001887 0.79520047 0.8773627 0.44872862 3.621616E-4 400.0 800.0 MS4A1_34110 309217 ms4a1 6 33 5.28115559484352 6.572715610979607E-4 0.027880071001839483 -1.4777907 1.4777907 -1.3100032 -1.4407545 -1.3074727 -1.2713267 -1.4777907 1.4526316 0.04393998 0.070367895 0.17587748 0.08254363 0.0062924405 0.05558566 CERK_8293 300129 cerk 6 33 4.933835828232387 0.0010600951384668322 0.03793647030076735 -1.4836698 1.4836698 -1.0674318 -1.0536729 -1.1647577 -1.0722007 1.0026056 -1.4836698 0.54811025 0.43165678 0.08171048 0.3745535 0.9759896 1.00969104E-4 SLC26A2_33072 117267 slc26a2 6 33 7.656362693524248 3.347651769758375E-5 0.003654148778604313 2.1031241 2.1031241 1.5481079 1.1604474 1.2579114 1.2596688 1.5577935 2.1031241 8.698283E-4 0.30557746 0.14311096 0.08077825 0.0024035205 1.3466862E-4 400.0 800.0 SDHA_9796 157074 sdha 6 33 7.194875058739817 5.753061039659446E-5 0.005313736378449088 1.2984574 1.2984574 -1.0380322 1.0182613 -1.0182728 1.0619078 -1.0835112 1.2984574 0.38584402 0.79298764 0.7063979 0.27629372 0.09750914 0.0012291648 LYRM1_9169 365361 lyrm1 6 33 6.488225234079882 1.362583569300968E-4 0.010626582888572322 1.4754386 1.4754386 -1.0078734 1.0064828 -1.0193793 1.0167587 -1.0187416 1.4754386 0.90271056 0.9331542 0.82078844 0.8069453 0.7995718 0.0010204123 GSTM7_8761 81869 gstm7 6 33 5.46846125366478 5.103635124581452E-4 0.023569514938976157 1.6348512 1.6348512 -1.0498198 -1.2366163 -1.1010633 1.0352045 -1.1455463 1.6348512 0.6207115 0.115707815 0.45760775 0.77662736 0.24145499 0.014645369 TIMP1_10022 116510 timp1 6 33 7.671493354960506 3.289655760074783E-5 0.003654148778604313 -3.1495104 3.1495104 1.0447081 -1.0092955 -1.2202502 -1.3686378 1.1706464 -3.1495104 0.8286677 0.9656591 0.259614 0.11032736 0.5823091 4.6700756E-5 400.0 800.0 ECHS1_8519 140547 echs1 6 33 12.29342390628933 3.139611892688521E-7 1.2759382731886149E-4 1.509826 1.509826 1.0234 1.0477483 -1.022191 1.0483171 -1.0953577 1.509826 0.6409532 0.3836572 0.64325875 0.48082832 0.1635191 7.1334006E-4 SQRDL_9936 691966 sqor 6 33 9.270830483421312 5.6857040746649545E-6 0.0010503046072471989 1.5452396 1.5452396 -1.0432491 -1.0621876 -1.1538321 -1.1129206 -1.0291243 1.5452396 0.69431496 0.44195044 0.10429001 0.09444928 0.7529521 8.786304E-6 HP_8823 24464 hp 6 33 8.453569243106562 1.3638606760291161E-5 0.0018919714590956243 4.3046103 4.3046103 1.0038775 -1.3067431 -1.7911592 -1.5357552 -1.4666942 4.3046103 0.98938775 0.36838394 0.09599569 0.1564096 0.32832882 7.949368E-5 400.0 800.0 VNN1_10157 29142 vnn1 6 33 6.808268838120873 9.17371492151764E-5 0.008104777704575584 6.4177723 6.4177723 -1.1325959 1.0102159 -1.2714238 -1.36226 -1.2146072 6.4177723 0.70155674 0.98086894 0.45217168 0.30191317 0.5290158 0.009969652 400.0 800.0 CNN2_32878 690976 cnn2 6 33 4.929924178883187 0.0010658889355020795 0.03793647030076735 -1.6440511 1.6440511 -1.0916371 -1.2156281 -1.2376413 -1.182644 -1.1190906 -1.6440511 0.32585666 0.028946612 0.020925408 0.14906563 0.31390384 0.0023891442 PLG_9501 85253 plg 6 33 6.2781229047116485 1.7751062123316785E-4 0.011985090274388042 2.7423158 2.7423158 -1.5181203 1.1043038 -1.2309004 -1.8301064 -1.7380117 2.7423158 0.13650858 0.6972301 0.60291976 0.042047035 0.061964195 3.289249E-4 400.0 800.0 H2AFZ_33045 58940 h2az1 6 33 7.9629993668749135 2.3570798105776447E-5 0.0029934913594336088 -1.3511219 1.3511219 1.3048841 1.0152388 1.1505939 -1.0611534 1.2745095 -1.3511219 0.0011931626 0.8182539 0.14491023 0.5024705 0.035942115 0.055462323 BHMT_8143 81508 bhmt 6 33 5.14170479291734 7.952202337011549E-4 0.03168406891923033 -2.4028661 2.4028661 1.9209248 1.0400535 -1.2652895 1.0755349 1.1518453 -2.4028661 0.012089503 0.87158763 0.1297172 0.84937924 0.5928466 0.00961373 400.0 800.0 ANXA5_32426 25673 anxa5 6 33 4.898007092571433 0.0011144247377363747 0.03800913564174779 -2.4132016 2.4132016 1.2855994 1.0833365 1.2509034 1.223896 1.1587461 -2.4132016 0.25416285 0.6142912 0.42823395 0.5624159 0.32775554 0.0014028462 400.0 800.0 SLC10A2_9833 29500 slc10a2 6 33 8.592464918915534 1.1717257170085205E-5 0.0018314974284317797 -7.065372 7.065372 1.0033723 -1.6950667 -1.3449168 1.0251658 1.1570798 -7.065372 0.9900655 0.053531654 0.29249665 0.92360044 0.39403117 0.01909282 400.0 800.0 YWHAH_10193 25576 ywhah 6 33 5.264531136055565 6.72304861756956E-4 0.027880071001839483 -1.3986722 1.3986722 1.0209485 1.0724307 1.0868375 -1.0740099 1.0520304 -1.3986722 0.73769677 0.3172794 0.3283395 0.48254564 0.61687356 1.6672579E-4 UTP14A_10144 317579 utp14a 6 33 5.680044458645933 3.850380522577579E-4 0.020691701588377385 -1.5245885 1.5245885 -1.0039582 1.0211867 1.1383333 -1.0866426 -1.1513296 -1.5245885 0.96842533 0.80042595 0.24826644 0.38350675 0.115495086 0.002122328 LHCGR_8997 25477 lhcgr 6 33 11.776363317898811 4.982610691817158E-7 1.6874441542954108E-4 3.2892196 3.2892196 -1.1648966 1.0140982 -1.2017782 1.0028574 -2.160271 3.2892196 0.5679633 0.9212503 0.25382584 0.98142296 0.035342887 0.0048455466 150.0 400.0 HSDL2_8837 313200 hsdl2 6 33 14.252747932728083 6.067049240776612E-8 3.082061014314519E-5 1.434793 1.434793 1.0277054 -1.0646483 -1.0162423 1.1158038 1.0194554 1.434793 0.49387822 0.23622613 0.6853159 0.107225895 0.5911945 7.4772077E-4