Benchmark Dose Analyses Data Source: mouse_4D_OV Work Source: mouse_4D_OV_curvefitprefilter_nofoldfilter BMDExpress3 Version: BMDExpress 3.20.0119 BETA Timestamp (Start Time): 04/30/2025 12:36.23 Operating System: Windows 11 BMDS Major Version: 3.x with shared library/DLL Model Averaging Method: Laplace Model Averaging Step Function Calculation Threshold: 0.5 hill version: ToxicR power version: ToxicR exponential 3 version: ToxicR exponential 5 version: ToxicR Models fit: hill, power, exponential 3, exponential 5 Constant Variance: 1 BMR Type: Relative Deviation BMR Factor: 0.25 Highest Dose: 400.0 Lowest Positive Dose: 1.0 Fit Selected Models with Multiple Threads: 20 Number of Available Processors On Machine: 20 Total Run Time: 1 seconds Curve Fit Prefilter Data Source: mouse_4D_OV_williams_0.05_NOMTC_nofoldfilter Work Source: mouse_4D_OV BMDExpress3 Version: BMDExpress 3.20.0119 BETA Timestamp (Start Time): 04/30/2025 12:25.36 Constant Variance: 1 BMR Factor: 2.0 Poly 2 BMR Factor: 5.0 Models Used: hill: Hill EPA BMDS MLE ToxicR,power: Power EPA BMDS MLE ToxicR,linear: Linear EPA BMDS MLE ToxicR,exponential 3: Exponential 3 EPA BMDS MLE ToxicR,exponential 5: Exponential 5 EPA BMDS MLE ToxicR, NOTEL/LOTEL Test: T-Test NOTEL/LOTEL p-Value Threshold: 0.05 NOTEL/LOTEL Fold Change Threshold: 2.0 Total Run Time: 12 seconds Williams Trend Test Data Source: mouse_4D_OV Work Source: null BMDExpress3 Version: BMDExpress 3.20.0119 BETA Timestamp (Start Time): 04/30/2025 12:15.41 Number of Permutations: 10000 Unadjusted P-Value Cutoff: 0.05 Multiple Testing Correction: false Filter Out Control Genes: true NOTEL/LOTEL Test: T-Test NOTEL/LOTEL p-Value Threshold: 0.05 NOTEL/LOTEL Fold Change Threshold: 2.0 Total Run Time: 23 seconds Chip: BioSpyder S1500_Mouse Provider: BioSpyder Chip File Creation Date: 10/31/24 Log Transformation: BASE2 BMDExpress3 Version: BMDExpress 3.20.0119 BETA Timestamp: 04/30/2025 12:11.51 Probe ID Entrez Gene IDs Genes Symbols Hill BMD Hill BMDL Hill BMDU Hill fitPValue Hill fitLogLikelihood Hill AIC Hill adverseDirection Hill BMD/BMDL Flagged Hill Hill Parameter Intercept Hill Parameter v Hill Parameter n Hill Parameter k Hill Execution Complete Hill RSquared Hill Residual 1 Hill Residual 2 Hill Residual 3 Hill Residual 4 Hill Residual 5 Hill Residual 6 Hill Is Step Function Less Than Lowest Dose Hill Z-Score Hill ABS Z-Score Hill Modelled Response BMR Multiples Hill ABS Modelled Response BMR Multiples Hill Fold Change Hill ABS Fold Change Hill BMD/Low Dose Hill BMD/High Dose Hill BMD Response/Low Dose Response Hill BMD Response/High Dose Response Power BMD Power BMDL Power BMDU Power fitPValue Power fitLogLikelihood Power AIC Power adverseDirection Power BMD/BMDL Power Parameter control Power Parameter slope Power Parameter power Power Execution Complete Power RSquared Power Residual 1 Power Residual 2 Power Residual 3 Power Residual 4 Power Residual 5 Power Residual 6 Power Is Step Function Less Than Lowest Dose Power Z-Score Power ABS Z-Score Power Modelled Response BMR Multiples Power ABS Modelled Response BMR Multiples Power Fold Change Power ABS Fold Change Power BMD/Low Dose Power BMD/High Dose Power BMD Response/Low Dose Response Power BMD Response/High Dose Response Exp 3 BMD Exp 3 BMDL Exp 3 BMDU Exp 3 fitPValue Exp 3 fitLogLikelihood Exp 3 AIC Exp 3 adverseDirection Exp 3 BMD/BMDL Exp 3 Execution Complete Exp 3 Parameter sign Exp 3 Parameter a Exp 3 Parameter b Exp 3 Parameter d Exp 3 RSquared Exp 3 Residual 1 Exp 3 Residual 2 Exp 3 Residual 3 Exp 3 Residual 4 Exp 3 Residual 5 Exp 3 Residual 6 Exp 3 Is Step Function Less Than Lowest Dose Exp 3 Z-Score Exp 3 ABS Z-Score Exp 3 Modelled Response BMR Multiples Exp 3 ABS Modelled Response BMR Multiples Exp 3 Fold Change Exp 3 ABS Fold Change Exp 3 BMD/Low Dose Exp 3 BMD/High Dose Exp 3 BMD Response/Low Dose Response Exp 3 BMD Response/High Dose Response Exp 5 BMD Exp 5 BMDL Exp 5 BMDU Exp 5 fitPValue Exp 5 fitLogLikelihood Exp 5 AIC Exp 5 adverseDirection Exp 5 BMD/BMDL Exp 5 Execution Complete Exp 5 Parameter a Exp 5 Parameter b Exp 5 Parameter c Exp 5 Parameter d Exp 5 RSquared Exp 5 Residual 1 Exp 5 Residual 2 Exp 5 Residual 3 Exp 5 Residual 4 Exp 5 Residual 5 Exp 5 Residual 6 Exp 5 Is Step Function Less Than Lowest Dose Exp 5 Z-Score Exp 5 ABS Z-Score Exp 5 Modelled Response BMR Multiples Exp 5 ABS Modelled Response BMR Multiples Exp 5 Fold Change Exp 5 ABS Fold Change Exp 5 BMD/Low Dose Exp 5 BMD/High Dose Exp 5 BMD Response/Low Dose Response Exp 5 BMD Response/High Dose Response MA BMD MA BMDL MA BMDU MA adverseDirection MA BMD/BMDL MA Execution Complete MA Hill Posterior Probability MA Power Posterior Probability MA Exp 3 Posterior Probability MA Exp 5 Posterior Probability MA RSquared MA Residual 1 MA Residual 2 MA Residual 3 MA Residual 4 MA Residual 5 MA Residual 6 MA Is Step Function MA Is Step Function Less Than Lowest Dose MA Z-Score MA ABS Z-Score MA Modelled Response BMR Multiples MA ABS Modelled Response BMR Multiples MA Fold Change MA ABS Fold Change MA BMD/Low Dose MA BMD/High Dose MA BMD Response/Low Dose Response MA BMD Response/High Dose Response Best Model Best BMD Best BMDL Best BMDU Best fitPValue Best fitLogLikelihood Best AIC Best adverseDirection Best BMD/BMDL Best BMDU/BMDL Best BMDU/BMD Best RSquared Best Is Step Function Best Is Step Function Less Than Lowest Dose Best Z-Score Best ABS Z-Score Best Modelled Response BMR Multiples Best ABS Modelled Response BMR Multiples Best Model Fold Change Best ABS Model Fold Change Best BMD/Low Dose Best BMD/High Dose Best BMD Response/Low Dose Response Best BMD Response/High Dose Response Prefilter P-Value Prefilter Adjusted P-Value Max Fold Change Max Fold Change Absolute Value NOTEL LOTEL FC Dose Level 1 FC Dose Level 2 FC Dose Level 3 FC Dose Level 4 FC Dose Level 5 Hoxa10_31922 15395 hoxa10 102.337 20.5782 210.541 9999.0 -27.74295133783646 65.48590267567292 1 4.973078306168665 0 3.84648 2.31007 1.74857 289.885 0.8550996296730153 0.14039908649444577 -0.26592804462884345 0.29266408258348386 -0.1156054900807093 -0.3209517698353723 0.12772820471969393 false 3.3626414316996507 3.3626414316996507 4.5720253115387965 4.5720253115387965 2.7737840198268224 2.7737840198268224 102.337 0.25584250000000003 1.0836615407081995 0.7837802620264128 140.676 56.6375 239.596 9999.0 -19.52335133783646 47.04670267567292 1 2.4837960715073932 3.86648 2.01253E-4 1.49147 0.9045451186102511 0.12039908649444575 -0.28601494936535676 0.27281540377852753 -0.10224275791953463 -0.14052296023399613 0.0497761881396972 false 0.3023099926721506 0.3023099926721506 4.752134405840879 4.752134405840879 2.8874730342355837 2.8874730342355837 140.676 0.35168999999999995 1.0832028302474481 0.7761632599324341 137.984 52.7771 236.238 9999.0 -17.24615133783646 42.49230267567292 1 2.6144672594742797 1.0 3.87321 0.00106151 1.31587 0.8992557474308422 0.11366908649444607 -0.29301641233854836 0.2625310759867143 -0.12233396120362627 -0.15400926713499086 0.09105831400198827 false 3.764649613223636 3.764649613223636 4.602829482911696 4.602829482911696 2.7929608434597832 2.7929608434597832 137.984 0.34496000000000004 1.0829852905809927 0.7834056419155331 128.295 45.7354 130.951 9999.0 -25.69545133783646 61.39090267567292 1 2.8051574928829743 3.86401 0.00182484 1.854920800500581 1.56864 0.8948653677874892 0.12286908649444594 -0.28351072879685013 0.27534499592516415 -0.10730552404306115 -0.18946861557541705 0.07301106887800124 false 3.6944161159238007 3.6944161159238007 4.687512568738299 4.687512568738299 2.8462109499376202 2.8462109499376202 128.295 0.32073749999999995 1.083267714733055 0.7790614647873094 103.39951311864148 21.258145371259054 212.00131654949644 1 4.863995015220721 true 0.966927 0.00115232 0.0319097 1.09415E-5 0.8570449171990322 0.1395230500984308 -0.2668156171450726 0.2916796341920973 -0.11580455259464095 -0.315415164863297 0.12646785990848652 true false 3.3635194332679825 3.3635194332679825 4.55344105345718 4.55344105345718 2.7745230052002894 2.7745230052002894 103.39951311864148 0.2584987827966037 1.084002674720726 0.7840221040399379 Model Average 103.39951311864148 21.258145371259054 212.00131654949644 9999.0 0.0 0.0 1 4.863995015220721 9.972709888235196 2.0503125223253647 0.8570449171990322 true false 3.3635194332679825 3.3635194332679825 4.55344105345718 4.55344105345718 2.7745230052002894 2.7745230052002894 103.39951311864148 0.2584987827966037 1.084002674720726 0.7840221040399379 0.8068857317845832 0.8068857317845832 2.749528408050537 2.749528408050537 -1.3252022 1.1162477 -1.1125135 1.0668329 2.7495284 Clu_30840 12759 clu 566.651 67.8681 NaN 9999.0 16.89994866216354 -23.799897324327077 -1 8.34929812386084 0 12.196 -0.334496 1.39075 57.8822 0.7531783796521949 -0.09456443405151305 0.14669133553733893 0.04248662887539467 -0.010530907875429207 0.06164767894884271 -0.05112415868319253 false -3.3860235538856265 3.3860235538856265 -0.9755594138068115 0.9755594138068115 -1.24246176557755 1.24246176557755 566.651 1.4166275 0.9737701080410877 0.9993396671054081 362.47 227.325 661.34 9999.0 22.93900866216354 -37.87801732432708 -1 1.594501264709117 12.1644 -7.12895E-4 1.0373 0.6901505519876772 -0.06296443405151386 0.1778250028491204 0.05508456292901087 -0.087968054693782 -0.04206033035696777 0.023842411892703197 false -0.4372402217459979 0.4372402217459979 -1.1076024636198964 1.1076024636198964 -1.2803764323497362 1.2803764323497362 362.47 0.9061750000000001 0.9735923076263895 1.002933665104898 383.96 263.037 717.525 9999.0 36.53455866216354 -65.06911732432708 -1 1.4597185947224156 -1.0 12.1813 6.59102E-6 0.60542 0.7300827922797114 -0.07986443405151356 0.16910054578087852 0.06620655489566651 -0.05151453153781027 -0.004577228374536446 -0.01973128363649579 false -3.8714748590568147 3.8714748590568147 -1.0247442588813718 1.0247442588813718 -1.2569213092479432 1.2569213092479432 383.96 0.9599 0.9742828271253104 1.0006721465065025 373.062 251.307 634.896 9999.0 18.03924866216354 -26.07849732432708 -1 1.4844871014337047 12.157 6.78324E-4 0.8373074099466752 1.25746 0.6627174672059784 -0.055564434051513345 0.18471714411247397 0.05842227537479161 -0.09394106107184008 -0.05492954697251662 0.02333949469553609 false -3.6696692146582843 3.6696692146582843 -1.0830519600187845 1.0830519600187845 -1.2733818530271603 1.2733818530271603 373.062 0.932655 0.9735355169298201 1.0022642293857806 384.0799932222536 260.5179903635149 737.5682090970806 -1 1.4742935514216347 true 0.0136508 1.75821E-4 0.986172 1.2347E-6 0.7311089186353196 -0.08006034167181397 0.1687979518372522 0.06588254643560276 -0.05095978985577254 -0.0036781265836651755 -0.02015039698713572 false false -3.868855428252955 3.868855428252955 -1.0242804931907143 1.0242804931907143 -1.2567268604356474 1.2567268604356474 384.0799932222536 0.960199983055634 0.9742806295835947 1.000659377753734 Model Average 384.0799932222536 260.5179903635149 737.5682090970806 9999.0 0.0 0.0 -1 1.4742935514216347 2.8311603665754967 1.9203505053966083 0.7311089186353196 false false -3.868855428252955 3.868855428252955 -1.0242804931907143 1.0242804931907143 -1.2567268604356474 1.2567268604356474 384.0799932222536 0.960199983055634 0.9742806295835947 1.000659377753734 0.009896390787628051 0.009896390787628051 -1.2056074142456055 1.2056074142456055 1.1810565 1.0794392 -1.0469896 -1.0777366 -1.2056074 Dbp_31391 13170 dbp 61.8045 17.1477 144.357 9999.0 -12.948351337836456 35.89670267567291 1 3.6042443009849716 0 7.07682 1.49909 1.39764 156.277 0.888613959984402 0.15690659683227537 -0.30849617608427504 0.0034729488910070216 0.07225438479882484 -0.1718166828979264 0.09063782829318612 false 4.556573225848252 4.556573225848252 3.669875565391425 3.669875565391425 2.268034798827187 2.268034798827187 61.8045 0.15451125 1.0453008358405977 0.8959208647833713 109.654 43.3595 209.091 9999.0 -5.803651337836463 19.607302675672926 1 2.5289498264509507 7.12089 0.00224869 1.05676 0.8876208357091538 0.11283659683227487 -0.35352904797119145 -0.03474779476316492 0.14113540116294132 0.06392525814823369 -0.035801483929635225 false 0.4788902781800664 0.4788902781800664 3.9258766346793483 3.9258766346793483 2.401294064728067 2.401294064728067 109.654 0.274135 1.044877653730914 0.8876652221313093 87.0909 34.1641 89.0063 9999.0 2.178648662163539 3.642702675672922 1 2.549193451605633 1.0 7.10451 2.81029E-4 0.839976 0.9002415328062838 0.1292165968322747 -0.3422929403026629 -0.044040355505746476 0.09758815164626178 0.013678550696338831 0.016021532641506298 false 5.676729476601714 5.676729476601714 3.815655959332446 3.815655959332446 2.3430196792804403 2.3430196792804403 87.0909 0.21772725 1.0442267157305194 0.8912212228602052 95.2983 30.3914 97.271 9999.0 -11.020351337836459 32.04070267567292 1 3.1356995729054926 7.10746 0.00158789 1.3938964124493292 1.11339 0.89689505355979 0.12626659683227537 -0.3399900529850566 -0.02334503082611583 0.13304856118425246 0.012592413248102119 -0.026760463331704898 false 5.659114986616796 5.659114986616796 3.9394216612001767 3.9394216612001767 2.4086104257241994 2.4086104257241994 95.2983 0.23824575 1.0449794667207764 0.8870208139929655 83.55223876693687 25.56431719047852 102.78363141993952 1 3.2683148994120628 true 0.27107 0.003054 0.725876 0.0 0.9031394754249376 0.1366725006122751 -0.3331659664988047 -0.031132544602409773 0.09085392076695165 -0.036450188829500796 0.03608950441119951 true false 5.618444633900197 5.618444633900197 3.515899436854137 3.515899436854137 2.3226262257244263 2.3226262257244263 83.55223876693687 0.20888059691734218 1.0478780182517955 0.8953460314883354 Model Average 83.55223876693687 25.56431719047852 102.78363141993952 9999.0 0.0 0.0 1 3.2683148994120628 4.020589740539657 1.2301720808062042 0.9031394754249376 true false 5.618444633900197 5.618444633900197 3.515899436854137 3.515899436854137 2.3226262257244263 2.3226262257244263 83.55223876693687 0.20888059691734218 1.0478780182517955 0.8953460314883354 0.1662306801471567 0.1662306801471567 2.1662118434906006 2.1662118434906006 150.0 400.0 -1.3794724 -1.0882102 1.1240354 1.3189176 2.1662118 Sytl2_29612 83671 sytl2 409.973 284.444 NaN 9999.0 21.87614866216354 -33.75229732432708 -1 1.441313580177469 0 5.0694 -0.702447 2.1926 442.46 0.6656293619101223 -0.07943751754760697 0.034237279296944756 -0.07345618137551746 0.0741118533901215 0.15512862745169187 -0.031100582359627538 false -3.168226436246781 3.168226436246781 -0.970822597527125 0.970822597527125 -1.2418883916040242 1.2418883916040242 409.973 1.0249325 0.9364959315888431 0.9980253716872735 401.754 319.024 658.593 9999.0 30.55222866216354 -53.10445732432708 -1 1.2593221826571042 5.06859 -3.33419E-6 1.9143 0.6931429356516412 -0.07862751754760744 0.03504950362359338 -0.0725453589578029 0.07503773732747643 0.14481350194684328 -0.023588691478312995 false -0.24512263331016965 0.24512263331016965 -0.9916591249121816 0.9916591249121816 -1.247670876495219 1.247670876495219 401.754 1.004385 0.936487384344263 0.9994346354431886 427.13 371.196 699.667 9999.0 34.56043866216354 -61.12087732432708 -1 1.1506858910117566 -1.0 5.06713 4.32149E-4 1.61191 0.6411527431778985 -0.07716751754760676 0.036525299005078615 -0.0705763918522111 0.08100412784535038 0.1586415207778007 -0.05080811697504206 false -2.9943078093283506 2.9943078093283506 -0.9025604520950687 0.9025604520950687 -1.2231132486609253 1.2231132486609253 427.13 1.067825 0.9364712503172835 0.9934328724219695 404.742 318.816 553.498 9999.0 24.63780866216354 -39.27561732432708 -1 1.2695159590484795 5.06855 0.00100199 0.6233756327981644 1.87148 0.6782011327255927 -0.07858751754760718 0.03509082494540117 -0.07243280377641437 0.07614337793175174 0.1502536229047413 -0.027263613232545225 false -3.3131966810742925 3.3131966810742925 -0.9800980176827949 0.9800980176827949 -1.2444622723650203 1.2444622723650203 404.742 1.011855 0.936485746491223 0.9986520095257655 418.61803951367784 295.0322716677262 NaN -1 1.4188889816946448 true 0.74279 5.98213E-5 0.257124 2.62065E-5 0.6600251886568951 -0.0788539162661488 0.03482551410384893 -0.07271577799291418 0.0758839904270543 0.15603099255166786 -0.036167444806304516 true false -3.110946712322819 3.110946712322819 -0.9433689410637688 0.9433689410637688 -1.2370339205248448 1.2370339205248448 418.61803951367784 1.0465450987841947 0.9358228484229636 0.9961312939983741 Model Average 418.61803951367784 295.0322716677262 NaN 9999.0 0.0 0.0 -1 1.4188889816946448 NaN NaN 0.6600251886568951 true false -3.110946712322819 3.110946712322819 -0.9433689410637688 0.9433689410637688 -1.2370339205248448 1.2370339205248448 418.61803951367784 1.0465450987841947 0.9358228484229636 0.9961312939983741 0.1726809551920252 0.1726809551920252 -1.200968861579895 1.200968861579895 1.0819799 1.0040342 1.1078048 1.1286604 -1.2009689 Akap8l_31490 54194 akap8l 497.866 305.256 NaN 9999.0 30.66144866216354 -51.32289732432708 -1 1.6309785884634538 0 9.36275 -0.452908 1.84471 305.771 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0.02949646874542644 -0.02377033510363269 false -4.438149837361465 4.438149837361465 -0.8456975738970357 0.8456975738970357 -1.2076938748949397 1.2076938748949397 466.29 1.1657250000000001 0.9656544097687351 0.9945358482083405 434.37 385.29 596.192 9999.0 33.77880866216354 -57.55761732432708 -1 1.12738456746866 9.35881 6.97452E-4 0.7660008496794953 1.53985 0.8229117879346708 0.02107042831420891 -0.0011895123383371953 -0.09894867238902805 0.05557881120228636 0.008119832380936387 -0.005420069543815131 false -4.515490271613395 4.515490271613395 -0.8889695335217761 0.8889695335217761 -1.2194115140940591 1.2194115140940591 434.37 1.085925 0.9656046179531517 0.9960602441508365 466.3953414953271 397.35885759076945 635.8351192817444 -1 1.173738379265366 true 0.0150199 1.8035E-5 0.984961 7.78032E-7 0.7880832971306104 0.016660405081596608 -0.005279066172512614 -0.09987125758110338 0.06594397713407218 0.029557884895403674 -0.02362214977112842 true false -4.440402838236814 4.440402838236814 -0.8463734180187811 0.8463734180187811 -1.2078095761541412 1.2078095761541412 466.3953414953271 1.1659883537383178 0.9656638547782123 0.9945612771433995 Model Average 466.3953414953271 397.35885759076945 635.8351192817444 9999.0 0.0 0.0 -1 1.173738379265366 1.6001533805912438 1.3632964627030155 0.7880832971306104 true false -4.440402838236814 4.440402838236814 -0.8463734180187811 0.8463734180187811 -1.2078095761541412 1.2078095761541412 466.3953414953271 1.1659883537383178 0.9656638547782123 0.9945612771433995 0.058448954239852524 0.058448954239852524 -1.2420096397399902 1.2420096397399902 -1.0155704 -1.0875382 1.015414 -1.0567567 -1.2420096 Calcoco1_30287 67488 calcoco1 644.929 201.86 NaN 9999.0 21.16814866216354 -32.33629732432708 -1 3.1949321311800256 0 9.71573 -0.363764 1.54309 171.872 0.8640237125982658 -0.0547691349792494 0.07482343955592086 -0.0046299421217099734 0.023277076301104316 0.046117648586879056 -0.0300495074313325 false -3.0720418982877815 3.0720418982877815 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482.5926289177277 291.1004430490076 853.8407913669063 9999.0 0.0 0.0 -1 1.6578216915887065 2.9331483745737885 1.769278559603671 0.8699910818726379 true false -3.320442349980211 3.320442349980211 -0.8651022428593019 0.8651022428593019 -1.2125133140523272 1.2125133140523272 482.5926289177277 1.2064815722943194 0.9671331255742115 0.9954050759937391 0.44312400113910877 0.44312400113910877 -1.1985994577407837 1.1985994577407837 1.0938866 1.0321689 1.0216743 -1.043886 -1.1985995 Gpr137b-ps_84207 83924 gpr137b 519.37 364.783 NaN 9999.0 36.69618866216354 -63.392377324327086 -1 1.423777972109446 0 7.36348 -0.515624 1.98288 401.981 0.8373076077674212 -0.0025570435333248653 -0.062000462335116246 0.04361724883987694 -0.022641266998773446 0.06059157565717932 -0.014443224029936808 false -4.3965773929925795 4.3965773929925795 -0.7969152669265192 0.7969152669265192 -1.1946179048193808 1.1946179048193808 519.37 1.298425 0.9562809285541823 0.9908007208993822 452.849 375.889 660.324 9999.0 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0.8957078991438868 -1.2212478690776378 1.2212478690776378 434.167 1.0854175 0.9569975385580873 0.9953346907846078 487.5069581391854 374.8249224230536 859.7599155860044 -1 1.3006257827993384 true 0.135551 1.67836E-4 0.864275 5.94119E-6 0.8693845478350567 -0.027578683364585466 0.05058614231108294 -0.011018622817363877 -0.017232883747826833 0.0690318095235769 -0.036173738019742885 true false -3.6080051668390447 3.6080051668390447 -0.8324549197800685 0.8324549197800685 -1.203580216626612 1.203580216626612 487.5069581391854 1.2187673953479634 0.9571946820092513 0.9925496813920407 Model Average 487.5069581391854 374.8249224230536 859.7599155860044 9999.0 0.0 0.0 -1 1.3006257827993384 2.29376400594734 1.7635849114189242 0.8693845478350567 true false -3.6080051668390447 3.6080051668390447 -0.8324549197800685 0.8324549197800685 -1.203580216626612 1.203580216626612 487.5069581391854 1.2187673953479634 0.9571946820092513 0.9925496813920407 0.4016298376276075 0.4016298376276075 -1.2107726335525513 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444.072 826.616 9999.0 42.11313866216354 -76.22627732432709 -1 1.227258192365202 -1.0 10.4414 7.15798E-5 1.06772 0.5924931518721891 0.03945746765136704 -0.08355487671957817 -0.03479485044817565 -0.03149827963245144 0.12820985047942735 -0.056962395836146484 false -2.5971671388281243 2.5971671388281243 -0.7219014792008502 0.7219014792008502 -1.1747843714008186 1.1747843714008186 544.991 1.3624775 0.9692050408259297 0.9912306787468423 441.749 395.123 610.678 9999.0 26.63348866216354 -43.26697732432708 -1 1.118003760854215 10.4367 6.5303E-4 0.6320953664103884 1.95903 0.7282865851598959 0.044157467651366744 -0.07924425166624616 -0.034469359021292334 -0.04757912040589751 0.09107386005884699 -0.01759735733360479 false -3.4628391319497096 3.4628391319497096 -0.8295666846694961 0.8295666846694961 -1.203353919028232 1.203353919028232 441.749 1.1043725 0.9691544083872756 0.9946047925082796 544.8449640883979 441.4991406004371 836.7388482663919 -1 1.2340793310433422 true 0.0151327 4.28455E-6 0.984862 6.97395E-7 0.5936804615566251 0.03947896139152007 -0.08353924692496406 -0.034836843205381385 -0.03172994295147191 0.127997881005383 -0.056513042829580584 true false -2.6019487277154973 2.6019487277154973 -0.7229145567638461 0.7229145567638461 -1.175132828217157 1.175132828217157 544.8449640883979 1.3621124102209947 0.9691909556184409 0.9912584202312548 Model Average 544.8449640883979 441.4991406004371 836.7388482663919 9999.0 0.0 0.0 -1 1.2340793310433422 1.895221918503466 1.5357375095984844 0.5936804615566251 true false -2.6019487277154973 2.6019487277154973 -0.7229145567638461 0.7229145567638461 -1.175132828217157 1.175132828217157 544.8449640883979 1.3621124102209947 0.9691909556184409 0.9912584202312548 0.26655560103098574 0.26655560103098574 -1.255981683731079 1.255981683731079 -1.089301 -1.0561596 -1.0691336 1.0045922 -1.2559817 Use1_31822 67023 use1 986.13 445.61 NaN 9999.0 35.85733866216354 -61.714677324327084 -1 2.212988936513992 0 9.28564 -0.378509 2.12593 435.265 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-0.04733354280329394 false -1.818411815827888 1.818411815827888 -0.447768411123976 0.447768411123976 -1.1050773074432745 1.1050773074432745 799.487 1.9987175 0.9653404460120586 0.9805506038393275 565.488 502.057 866.571 9999.0 39.39185866216354 -68.78371732432709 -1 1.1263422280737048 9.28525 7.52031E-4 0.8096720417765658 1.87591 0.48789373958145876 0.0385067901611329 -0.08997911972275752 -0.06934914268824954 0.0072164710799640375 0.09130676180393493 -0.015916047560287083 false -3.146664315349953 3.146664315349953 -0.5473422174915406 0.5473422174915406 -1.129907596591918 1.129907596591918 565.488 1.41372 0.9653293491226025 0.9840023604248227 799.9769787928221 623.3074216355062 1437.9953420982022 -1 1.283438879475797 true 0.0247266 2.8022E-6 0.975269 1.62323E-6 0.3739534933708315 0.03912108254300328 -0.08924263805846344 -0.06705360680467543 0.016489654721011604 0.10823389916224002 -0.046662905890345385 true false -1.8271961713477616 1.8271961713477616 -0.4504794150048043 0.4504794150048043 -1.105610823022122 1.105610823022122 799.9769787928221 1.9999424469820553 0.9653823898679604 0.9806682067660639 Model Average 799.9769787928221 623.3074216355062 1437.9953420982022 9999.0 0.0 0.0 -1 1.283438879475797 2.3070403017583576 1.797545904718608 0.3739534933708315 true false -1.8271961713477616 1.8271961713477616 -0.4504794150048043 0.4504794150048043 -1.105610823022122 1.105610823022122 799.9769787928221 1.9999424469820553 0.9653823898679604 0.9806682067660639 0.009459894978076644 0.009459894978076644 -1.1733448505401611 1.1733448505401611 -1.0931472 -1.0777622 -1.0245851 1.016467 -1.1733449 H2-q6_31131 110557 h2-q6 166.075 70.812 405.417 9999.0 6.697648662163541 -3.395297324327082 -1 2.3452945828390668 0 4.04868 -0.816574 1.66203 215.049 0.8060042801939745 -0.008085779838562068 -0.20526783160156725 0.14433899652378113 0.04648846134805851 0.07111137236409082 -0.04048598374191936 false -3.707086276125815 3.707086276125815 -1.869907777164652 1.869907777164652 -1.5177944174375513 1.5177944174375513 166.075 0.4151875 0.9205102487623246 1.081250968760236 242.951 186.995 365.597 9999.0 14.46664866216354 -20.93329732432708 -1 1.2992379475387041 4.03045 -2.024E-4 1.34208 0.828099162655711 0.0101442201614379 -0.18694387189636252 0.16206791620731043 0.0369006198506443 -0.03170827591974046 0.004380366777052558 false -0.3602522172842503 0.3602522172842503 -1.9526110755083512 1.9526110755083512 -1.546077612719378 1.546077612719378 242.951 0.6073775 0.9201706527078654 1.0901507878271688 227.587 128.253 297.701 9999.0 17.46294866216354 -26.92589732432708 -1 1.7745159957271956 -1.0 4.03453 5.08425E-4 1.15318 0.8199782678580653 0.006064220161437817 -0.1905844047699885 0.1626622688229018 0.05225760184714234 -0.002123911536102696 -0.034044993400094814 false -4.023230366640333 4.023230366640333 -1.8459470280021841 1.8459470280021841 -1.5097057459561893 1.5097057459561893 227.587 0.5689675 0.9203525184643606 1.079161539836427 221.403 102.66 359.926 9999.0 8.485048662163539 -6.970097324327078 -1 2.1566627703097603 4.03424 0.00191439 0.6893197756737747 1.41488 0.8295886749875222 0.006354220161438384 -0.19075744058842936 0.15846896343193695 0.03904322116957015 -0.006906392704582487 -0.006159387473581024 false -4.088547127063182 4.088547127063182 -1.931682985939365 1.931682985939365 -1.5388610702706318 1.5388610702706318 221.403 0.5535074999999999 0.9202418524120872 1.0878961824825022 172.37419308125502 73.44322131369104 1326.283667801196 -1 2.3470402032749833 true 0.896174 0.00267243 0.101119 3.47063E-5 0.8090816751392904 -0.006606278265773646 -0.20373413688246966 0.14623914603074795 0.047045407049158605 0.06342789530654125 -0.03971405349498047 true false -3.702728915970575 3.702728915970575 -1.8567307022924013 1.8567307022924013 -1.517050196059154 1.517050196059154 172.37419308125502 0.43093548270313753 0.9200231427873633 1.0805114103637141 Model Average 172.37419308125502 73.44322131369104 1326.283667801196 9999.0 0.0 0.0 -1 2.3470402032749833 18.058626025353202 7.69421248095997 0.8090816751392904 true false -3.702728915970575 3.702728915970575 -1.8567307022924013 1.8567307022924013 -1.517050196059154 1.517050196059154 172.37419308125502 0.43093548270313753 0.9200231427873633 1.0805114103637141 0.2210592232849672 0.2210592232849672 -1.552266240119934 1.552266240119934 -1.1465425 1.1076294 -1.0082293 -1.1570011 -1.5522662 Tuba4a_29527 22145 tuba4a 218.248 104.271 1772.46 9999.0 -1.1651513378364626 12.330302675672925 1 2.093084366698315 0 5.20745 1.11302 1.91073 349.385 0.8673859295744561 0.08305674438476629 0.026518042285666787 0.020461066288657292 -0.09179302190399952 -0.1773013248315518 0.05592855526434448 false 3.277897122381777 3.277897122381777 1.9508671870078196 1.9508671870078196 1.5454658860483428 1.5454658860483428 218.248 0.54562 1.061817823920973 0.9475430242706726 261.275 166.571 386.424 9999.0 7.31524866216354 -6.630497324327081 1 1.5685503478996943 5.2122 3.26272E-5 1.65247 0.917168394016398 0.07830674438476581 0.02175079412568337 0.015496118796414216 -0.09101778950093298 -0.12617646067008614 0.028482797736414156 false 0.27982466901483 0.27982466901483 2.021363312694582 2.021363312694582 1.569970625956526 1.569970625956526 261.275 0.6531874999999999 1.061758066671018 0.9439176137200046 256.067 155.829 409.154 9999.0 11.716948662163539 -15.433897324327077 1 1.6432563900172625 1.0 5.213 5.09835E-4 1.38247 0.8853005660681965 0.0775067443847659 0.020837131513712137 0.012631425846699962 -0.10363297908408953 -0.1495901779982507 0.0663407184408058 false 3.455065387857134 3.455065387857134 1.9012802613920126 1.9012802613920126 1.5284608991957969 1.5284608991957969 256.067 0.6401675 1.0617254822233946 0.9501896274174316 252.738 145.144 392.399 9999.0 1.5027486621635404 6.994502675672919 1 1.7412914071542742 5.21198 0.00135256 1.4149426496625344 1.70046 0.9081587614386285 0.07852674438476637 0.021974803647712093 0.015746500267416863 -0.09190476986681162 -0.13616465991982185 0.03797552159334394 false 3.5290896067837623 3.5290896067837623 1.9925934313744154 1.9925934313744154 1.559912214943255 1.559912214943255 252.738 0.631845 1.061760447007612 0.9454098822735072 230.78838616671646 112.74961081740544 529.2332387190681 1 2.0469107120952392 true 0.74897 3.46995E-4 0.250668 1.53336E-5 0.8724534693946393 0.08166210812923769 0.02509058469567993 0.018494919296054846 -0.09476237286828049 -0.17033842804397903 0.058526835015582535 true false 3.257057159661899 3.257057159661899 1.8937970499852237 1.8937970499852237 1.5411944470972807 1.5411944470972807 230.78838616671646 0.5769709654167912 1.063252286359009 0.9495059681896023 Model Average 230.78838616671646 112.74961081740544 529.2332387190681 9999.0 0.0 0.0 1 2.0469107120952392 4.693880846969354 2.293153687277668 0.8724534693946393 true false 3.257057159661899 3.257057159661899 1.8937970499852237 1.8937970499852237 1.5411944470972807 1.5411944470972807 230.78838616671646 0.5769709654167912 1.063252286359009 0.9495059681896023 0.9493912805134036 0.9493912805134036 1.516676664352417 1.516676664352417 -1.0399566 -1.0434382 -1.108324 -1.0539491 1.5166767 Hmgcs2_29615 15360 hmgcs2 215.36 29.4816 NaN 9999.0 8.223148662163542 -6.446297324327084 -1 7.304895256702486 0 9.62901 -0.606103 1.39358 196.92 0.7562055382022418 -0.03061264968872024 0.08164394256033525 0.0021799406497784446 -0.11720878763624398 0.1672271196315105 -0.07263011708906042 false -2.623995295177683 2.623995295177683 -1.3717714679284667 1.3717714679284667 -1.3581219213637548 1.3581219213637548 215.36 0.5384 0.9666053682212233 1.0130269772877083 294.027 225.043 448.864 9999.0 16.31374866216354 -24.62749732432708 -1 1.3065369729340615 9.61092 -1.58246E-4 1.34032 0.835113271734955 -0.012522649688721188 0.09950760177392581 0.014357226828389358 -0.14731827805497488 0.06967160736655487 -0.009829019567154873 false -0.31127541613784243 0.31127541613784243 -1.5106515427971083 1.5106515427971083 -1.4008709864913635 1.4008709864913635 294.027 0.7350675 0.9665196378501418 1.0180165859686185 266.877 204.055 390.765 9999.0 26.45713866216354 -44.91427732432708 -1 1.3078679767709687 -1.0 9.62578 6.58003E-5 0.836425 0.818858157179842 -0.027382649688721727 0.08754869867003023 0.017005053994189723 -0.11179372919049335 0.12431242642238871 -0.06246977548609678 false -3.819444185624638 3.819444185624638 -1.3933029725308899 1.3933029725308899 -1.3646616902400615 1.3646616902400615 266.877 0.6671925000000001 0.9668629339676561 1.0137966658856554 288.881 181.568 393.84 9999.0 11.147248662163541 -12.294497324327082 -1 1.5910347638350368 9.61203 6.29903E-4 0.6710765936602096 1.3095 0.8328189147919469 -0.013632649688721798 0.09844284658363911 0.013930009129957455 -0.1444212938925844 0.07864979233229796 -0.017822601893289658 false -3.966168676987284 3.966168676987284 -1.4892754881340218 1.4892754881340218 -1.3942028813027338 1.3942028813027338 288.881 0.7222025 0.9665281927641133 1.0172472243050432 266.1769257541932 197.31328340395254 401.86584382746656 -1 1.3490066211571703 true 0.0474915 1.20334E-4 0.952387 1.30842E-6 0.8163415828917109 -0.027535611983294572 0.08726835579413894 0.016299296560013943 -0.11205657540165426 0.12634253227754044 -0.06294721948140136 true false -3.816681153309038 3.816681153309038 -1.3861989371844077 1.3861989371844077 -1.364354793813152 1.364354793813152 266.1769257541932 0.665442314385483 0.9667035411089135 1.0136063335638497 Model Average 266.1769257541932 197.31328340395254 401.86584382746656 9999.0 0.0 0.0 -1 1.3490066211571703 2.036689253225495 1.509769649224134 0.8163415828917109 true false -3.816681153309038 3.816681153309038 -1.3861989371844077 1.3861989371844077 -1.364354793813152 1.364354793813152 266.1769257541932 0.665442314385483 0.9667035411089135 1.0136063335638497 0.2213779694458623 0.2213779694458623 -1.3982576131820679 1.3982576131820679 1.0806301 1.0163629 -1.1209733 -1.0341318 -1.3982576 Cirbp_31851 12696 cirbp 398.02 203.523 406.259 9999.0 24.35200866216354 -38.70401732432708 -1 1.955651204040821 0 8.61748 -0.453197 1.60125 227.299 0.8499199215468269 0.02657784606933511 -0.0016792941796648364 -0.10231805158555929 0.0348663839449781 0.036323121314422835 -0.020339261687437826 false -3.845370117685076 3.845370117685076 -1.0022976797602323 1.0022976797602323 -1.2506408515246559 1.2506408515246559 398.02 0.99505 0.9626509862652612 1.0000891746660299 385.711 280.483 600.267 9999.0 32.16173249216354 -56.323464984327074 -1 1.3751671224280972 8.60916 -1.49062E-4 1.28927 0.8811066078320172 0.034897846069336325 0.006713434863771184 -0.09412423346717524 0.029446913460123625 -0.013951045082743363 0.002697459175069028 false -0.35380853514491956 0.35380853514491956 -1.0480158347901947 1.0480158347901947 -1.2634637467688548 1.2634637467688548 385.711 0.9642775 0.9626231595686925 1.001868713474456 414.289 321.756 605.046 9999.0 41.96626866216354 -75.93253732432709 -1 1.2875874886560004 -1.0 8.62044 4.05403E-5 0.799822 0.8548581994791102 0.023617846069335258 -0.002069844628788786 -0.09163249512021743 0.05530911926508786 0.023862545369475185 -0.03278640719945258 false -3.983924200761573 3.983924200761573 -0.9728263843754246 0.9728263843754246 -1.2424436340309604 1.2424436340309604 414.289 1.0357224999999999 0.9629507772591196 0.9989469502655137 384.523 282.847 550.336 9999.0 26.93217866216354 -43.86435732432708 -1 1.3594734962718362 8.61061 5.29046E-4 0.7001749826241249 1.26599 0.8809618723125888 0.03344784606933615 0.00529796826466189 -0.09509064488813301 0.030743670556216074 -0.008329411938719389 0.001159170060965664 false -4.310468966681827 4.310468966681827 -1.0477274434715051 1.0477274434715051 -1.2633864285009417 1.2633864285009417 384.523 0.9613075000000001 0.9626328100395046 1.001857169353579 405.9142096194061 314.45536621155605 600.5503953091685 -1 1.290848410411032 true 0.0583906 2.11584E-4 0.941395 3.27646E-6 0.8550786821775398 0.023789131752655734 -0.0020491257615073977 -0.09226093140641645 0.05410596154332303 0.02457811675269639 -0.0320558170257641 true false -3.991039035141486 3.991039035141486 -0.9888272640465801 0.9888272640465801 -1.2429253983689648 1.2429253983689648 405.9142096194061 1.0147855240485153 0.9634720697988153 0.9995732347948972 Model Average 405.9142096194061 314.45536621155605 600.5503953091685 9999.0 0.0 0.0 -1 1.290848410411032 1.9098112477595195 1.4795007937077578 0.8550786821775398 true false -3.991039035141486 3.991039035141486 -0.9888272640465801 0.9888272640465801 -1.2429253983689648 1.2429253983689648 405.9142096194061 1.0147855240485153 0.9634720697988153 0.9995732347948972 0.3415380540000441 0.3415380540000441 -1.291980266571045 1.291980266571045 -1.0198328 -1.0957531 -1.0199933 -1.1050514 -1.2919803 Gdf7_29562 238057 gdf7 82.0378 23.6581 170.413 9999.0 -34.357151337836456 78.71430267567291 1 3.467641103892536 0 1.81691 4.03442 1.81047 316.628 0.8317293175651423 0.21969103678703306 -0.6480380290567782 0.599853728868879 -0.17599241807679622 -0.3583131292229602 0.1299110479887693 false 4.342083530963476 4.342083530963476 7.57236566863333 7.57236566863333 5.418027954969997 5.418027954969997 82.0378 0.2050945 1.1771075226756655 0.5027030422416242 103.534 35.4268 196.144 9999.0 -26.66395133783646 61.32790267567292 1 2.9224767689997404 1.85352 3.46598E-4 1.47286 0.8498050663812418 0.18308103678703302 -0.6848747879166106 0.5606785425983922 -0.18493734340994994 -0.12184255366496988 0.17441322289738892 false 0.31800607508945583 0.31800607508945583 7.320402177534673 7.320402177534673 5.121816841439626 5.121816841439626 103.534 0.25883500000000004 1.173466208222361 0.5167123611321982 117.663 44.4868 210.892 9999.0 -27.23355133783646 62.46710267567292 1 2.6448969132416806 1.0 1.8621 0.0022075 1.36189 0.8572055625827036 0.174501036787033 -0.6935577009490677 0.5520248219935657 -0.17823584612225218 -0.037421650763186154 0.05347249920629693 false 4.748195414881377 4.748195414881377 7.669455240832051 7.669455240832051 5.536661749140654 5.536661749140654 117.663 0.2941575 1.1726015918102843 0.504264565244862 89.8631 30.8113 175.935 9999.0 -33.37815133783646 76.75630267567291 1 2.9165630791300594 1.83507 0.00287204 2.8191347172188594 1.68969 0.8412849707844181 0.2015310367870331 -0.6662474818888102 0.5811493766846041 -0.1796653324183619 -0.2625706196390589 0.15424639923913652 false 4.414910724658481 4.414910724658481 7.4403818566995366 7.4403818566995366 5.260764563114339 5.260764563114339 89.8631 0.22465775000000002 1.175322865591903 0.5098874880204816 82.08234278501196 23.677082616353903 170.53610466760958 1 3.466742255159307 true 0.998114 7.4555E-4 0.00113706 3.30617E-6 0.8318014815503221 0.21961245073165125 -0.6481171591824033 0.5997702285918096 -0.17600148615288136 -0.35777141738479745 0.12985774849544462 true false 4.342038491250103 4.342038491250103 7.570590380370711 7.570590380370711 5.4179329923510195 5.4179329923510195 82.08234278501196 0.2052058569625299 1.1771392175856954 0.5027321730961974 Model Average 82.08234278501196 23.677082616353903 170.53610466760958 9999.0 0.0 0.0 1 3.466742255159307 7.202580969575165 2.077622286126427 0.8318014815503221 true false 4.342038491250103 4.342038491250103 7.570590380370711 7.570590380370711 5.4179329923510195 5.4179329923510195 82.08234278501196 0.2052058569625299 1.1771392175856954 0.5027321730961974 0.14113587148090656 0.14113587148090656 5.091135501861572 5.091135501861572 -1.824637 1.3084817 -1.1956717 1.189914 5.0911355 Cyp2a4_30021 13086 cyp2a4 48.4925 14.4915 121.097 9999.0 -9.20575133783646 28.41150267567292 1 3.3462719525238933 0 1.36145 1.27061 1.48441 100.431 0.894996484127638 0.22528965632915487 -0.2533684099418112 -0.16339798853327014 -0.033097925626546676 -0.0826605224301451 0.07604870714093614 false 3.983795185435959 3.983795185435959 3.4972924239823 3.4972924239823 2.1823452269446513 2.1823452269446513 48.4925 0.12123125 1.2352308569934585 0.6767816492970474 111.699 41.2538 224.694 9999.0 -3.1321513378364614 14.264302675672923 1 2.7076051175891678 1.42955 0.00254858 1.02608 0.8362608454316538 0.15718965632915483 -0.32266193687637346 -0.2184827487836014 0.0906593893513925 0.23265135472801224 -0.05801752200087584 false 0.4835710123352943 0.4835710123352943 3.7021951325677906 3.7021951325677906 2.2844479470002845 2.2844479470002845 111.699 0.2792475 1.223015967459027 0.6681477036114855 NaN NaN NaN 9999.0 10.96014866216354 -13.92029732432708 1 NaN 1.0 1.68248 5.26235E-24 1.33967 -0.0029557307910739183 -0.09574034367084505 -0.5730433568763733 -0.4443496033954619 -0.021154235343933125 0.41537563945770284 0.8808980479431154 false NaN NaN NaN NaN 1.0 1.0 NaN NaN NaN NaN 66.2265 23.8036 158.931 9999.0 -9.10965133783646 28.21930267567292 1 2.7822052126569092 1.37993 0.0064792 1.8635681309225 1.36565 0.8993610974927521 0.20680965632915482 -0.2717158178107022 -0.1698504204993685 0.051303178011693706 -0.018277414411210113 0.022107612011331046 false 4.104508638440047 4.104508638440047 3.6074464498043266 3.6074464498043266 2.2366514272369815 2.2366514272369815 66.2265 0.16556625 1.2322018876638905 0.6696881392282451 48.75788517290126 14.544595327325894 123.06239505597011 1 3.3523026303314603 true 0.991757 0.00822451 0.0 1.86762E-5 0.8953139904591596 0.22472896855998892 -0.25393891166117966 -0.16385141516629176 -0.03207882156173669 -0.08006644032364685 0.07494460754329291 false false 3.9857179859950795 3.9857179859950795 3.4944575224455643 3.4944575224455643 2.183167393480206 2.183167393480206 48.75788517290126 0.12189471293225315 1.2354308459895567 0.6768741279970281 Model Average 48.75788517290126 14.544595327325894 123.06239505597011 9999.0 0.0 0.0 1 3.3523026303314603 8.461039464244472 2.5239485802055652 0.8953139904591596 false false 3.9857179859950795 3.9857179859950795 3.4944575224455643 3.4944575224455643 2.183167393480206 2.183167393480206 48.75788517290126 0.12189471293225315 1.2354308459895567 0.6768741279970281 0.2172307171914183 0.2172307171914183 1.9678746461868286 1.9678746461868286 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