Curve Fit Prefilter Data Source: mouse_4D_HE_williams_0.05_NOMTC_nofoldfilter Work Source: mouse_4D_HE BMDExpress3 Version: BMDExpress 3.20.0119 BETA Timestamp (Start Time): 04/30/2025 12:23.59 Constant Variance: 1 BMR Factor: 2.0 Poly 2 BMR Factor: 5.0 Models Used: hill: Hill EPA BMDS MLE ToxicR,power: Power EPA BMDS MLE ToxicR,linear: Linear EPA BMDS MLE ToxicR,exponential 3: Exponential 3 EPA BMDS MLE ToxicR,exponential 5: Exponential 5 EPA BMDS MLE ToxicR, NOTEL/LOTEL Test: T-Test NOTEL/LOTEL p-Value Threshold: 0.05 NOTEL/LOTEL Fold Change Threshold: 2.0 Total Run Time: 23 seconds Williams Trend Test Data Source: mouse_4D_HE Work Source: null BMDExpress3 Version: BMDExpress 3.20.0119 BETA Timestamp (Start Time): 04/30/2025 12:14.18 Number of Permutations: 10000 Unadjusted P-Value Cutoff: 0.05 Multiple Testing Correction: false Filter Out Control Genes: true NOTEL/LOTEL Test: T-Test NOTEL/LOTEL p-Value Threshold: 0.05 NOTEL/LOTEL Fold Change Threshold: 2.0 Total Run Time: 19 seconds Chip: BioSpyder S1500_Mouse Provider: BioSpyder Chip File Creation Date: 10/31/24 Log Transformation: BASE2 BMDExpress3 Version: BMDExpress 3.20.0119 BETA Timestamp: 04/30/2025 12:11.51 Probe ID Gene ID Gene Symbol Best Model Best BMD Best BMDL Goodness of Fit Max Fold Change Max Fold Change Unsigned FC Dose Level 1 FC Dose Level 2 FC Dose Level 3 FC Dose Level 4 FC Dose Level 5 NOTEL/LOTEL T-Test p-Value Level 1 NOTEL/LOTEL T-Test p-Value Level 2 NOTEL/LOTEL T-Test p-Value Level 3 NOTEL/LOTEL T-Test p-Value Level 4 NOTEL/LOTEL T-Test p-Value Level 5 NOTEL LOTEL Abcg1_29054 11307 abcg1 Linear 309.787 214.38 0.08795879592980849 2.2170322 2.2170322 1.3698504 1.2278211 1.1135695 1.5943012 2.2170322 0.005626827 0.110042885 0.54175574 0.037059143 0.005206965 150.0 400.0 Dbp_31391 13170 dbp Linear 243.336 177.317 0.46989380029480543 4.4148574 4.4148574 -1.4931802 -1.0389555 1.1354842 1.5666989 4.4148574 0.2027164 0.91242415 0.7158974 0.053709876 5.507227E-5 150.0 400.0 Hspa8_84119 15481 hspa8 Power 387.561 322.824 0.5563872437308899 1.2545338 1.2545338 -1.0491476 -1.0007122 -1.1036104 1.0066775 1.2545338 0.34050888 0.9910942 0.32629332 0.8998538 0.029942177 Bhlhe40_32105 20893 bhlhe40 Linear 264.501 189.331 0.7947820401708666 1.8524662 1.8524662 1.041439 -1.0249083 1.1111568 1.3665854 1.8524662 0.69245845 0.852379 0.45394433 0.03440872 0.003663872 Slc22a17_30441 59049 slc22a17 Exp 5 32.4565 0.039402 0.2808443399203392 2.441855 2.441855 1.6344843 1.7797587 1.5196546 2.441855 1.8439338 0.017038181 8.92058E-4 0.02938564 0.013499927 0.003199134 50.0 150.0 Nfil3_31222 18030 nfil3 Linear 376.37 244.374 0.33469161674423253 -1.6447392 1.6447392 1.1160307 1.0614403 -1.1170784 -1.0126292 -1.6447392 0.437188 0.43576682 0.6075556 0.88688624 0.014275326 Cxcl1_29501 14825 cxcl1 Linear 385.378 247.415 0.014582071650066641 1.6593654 1.6593654 1.2680345 1.0813295 -1.1051424 1.1744652 1.6593654 0.07812071 0.3577748 0.43972528 0.11894176 0.008893069 Lcn2_30771 16819 lcn2 Exp 5 115.577 5.91437 0.6804135223018921 -1.9598635 1.9598635 -1.1778525 -1.4234565 -1.7807385 -1.4746103 -1.9598635 0.370959 0.09049617 5.669169E-4 0.022094475 6.7260815E-4 Star_29723 20845 star Exp 5 226.929 8.24822 0.24776864976309076 2.2096248 2.2096248 1.1445247 1.646045 1.2573863 2.2096248 1.9705088 0.2070722 1.18035496E-4 0.15148954 0.04574593 0.029203452 50.0 150.0 Bhlhe40_31406 20893 bhlhe40 Linear 240.984 175.202 0.37640450912333967 1.8143212 1.8143212 -1.006597 1.1342783 1.0718747 1.4012161 1.8143212 0.93002766 0.13690732 0.53405994 0.07503707 5.4616858E-6 Ddit4_29434 74747 ddit4 Exp 5 273.761 3.97524 0.9426128495360875 -2.1449075 2.1449075 1.2636771 -1.043263 -1.3431234 -1.9056184 -2.1449075 0.36189646 0.8616006 0.3978337 0.002258729 0.0059488555 150.0 400.0 Cldn5_31612 12741 cldn5 Power 394.174 386.306 0.603428120140145 -1.6376575 1.6376575 1.0785303 1.1751842 1.0513672 1.1610553 -1.6376575 0.37774664 0.3655235 0.6413792 0.17137302 0.02594196 Klhl24_30498 75785 klhl24 Linear 320.086 216.936 0.48208803304925385 -1.3262199 1.3262199 -1.0159584 -1.0087365 -1.1037673 -1.0686588 -1.3262199 0.6112224 0.8837741 0.3324175 0.066078715 0.0089845555 Mthfd1l_32017 270685 mthfd1l Linear 217.287 162.401 0.360280524217522 2.6477325 2.6477325 1.1192957 1.2705973 1.1279325 1.5053248 2.6477325 0.49259946 0.06924729 0.27064836 0.030585596 0.002838101 150.0 400.0 Ifi44_29813 99899 ifi44 Linear 388.807 250.292 0.3447581482932477 -1.5190516 1.5190516 1.2222434 1.1384872 -1.0592451 -1.1585002 -1.5190516 0.064194135 0.1597637 0.8092419 0.2708881 0.009354818 Emp3_31231 13732 emp3 Hill 66.7229 30.2769 0.3006352953953406 2.1254392 2.1254392 1.3040916 1.3482999 1.265899 2.1254392 1.936842 0.016235154 0.03761887 0.059249446 0.024424577 0.007331542 50.0 150.0 Cxcl5_30049 20311 cxcl5 Exp 5 278.005 5.55764 0.9998143662143048 1.6736174 1.6736174 1.1993706 1.2623127 1.4463648 1.5386801 1.6736174 0.027741933 0.26983482 0.073772885 0.014322275 0.017232327 Sertad1_30462 55942 sertad1 Hill 151.924 89.5676 0.7698030745966825 1.4397552 1.4397552 1.0515002 1.1164176 -1.0379481 1.4143912 1.4397552 0.37378028 0.11470992 0.6837219 0.045678873 0.02658324 Hsp90aa1_31929 15519 hsp90aa1 Hill 113.15 0.0796791 0.31258529158090287 1.4145427 1.4145427 -1.0232105 1.1111333 -1.1542403 1.4145427 1.4018123 0.7931025 0.059614837 0.14062342 0.03313947 0.026476823 Ephx1_29453 13849 ephx1 Exp 5 129.869 76.0407 0.7709127796431526 1.9401324 1.9401324 1.1087066 1.2052022 1.1850004 1.7567575 1.9401324 0.31756777 0.09704774 0.22338916 0.011162471 0.0053917035 Txlnb_30194 378431 txlnb Linear 380.228 248.812 0.21172013188908756 -1.330279 1.330279 -1.0362359 -1.0439749 -1.1632096 -1.083267 -1.330279 0.41979033 0.5712214 0.09073328 0.22663344 0.01460231 Id2_31090 15902 id2 Exp 5 222.774 1.05883 0.4371543547951495 2.5577848 2.5577848 1.4340057 1.5832837 1.4997619 2.5577848 1.9322783 0.030098181 0.023565378 0.03149536 0.03335372 0.022340484 50.0 150.0 Hlf_30768 217082 hlf Linear 289.394 203.653 0.7654048147511998 1.9453955 1.9453955 -1.0898174 1.0913897 1.1130259 1.2977448 1.9453955 0.36432186 0.482641 0.274417 0.307387 0.005916207 Krt18_29525 16668 krt18 Exp 5 145.913 8.2051 0.24152336100306648 3.8595705 3.8595705 2.1106873 2.1226482 1.5694212 3.8595705 3.57961 0.03453793 0.02668691 0.15635127 0.021183982 0.0095215775 0.0 1.0 Gsta3_30777 14859 gsta3 Linear 355.997 235.333 0.2613173119633778 1.7566721 1.7566721 1.1452333 1.1737963 -1.0113896 1.3485327 1.7566721 0.09715573 0.23698266 0.92431533 0.19687332 4.137678E-4 Ccl2_30705 20296 ccl2 Linear 308.918 214.145 0.202168694906406 2.0065835 2.0065835 1.197672 1.2007538 1.0609381 1.2242756 2.0065835 0.16859157 0.04645707 0.7577396 0.015710186 0.007823064 150.0 400.0 Krt8_31071 16691 krt8 Exp 5 198.194 30.3274 0.6062724764123391 3.0503736 3.0503736 1.5894173 1.8742919 1.5170643 2.9855554 3.0503736 0.04893231 0.07417912 0.04896931 0.033554208 0.021528866 50.0 150.0 S100a4_30373 20198 s100a4 Hill 343.741 40.9603 0.02138142990637326 2.6102858 2.6102858 1.5810939 1.7704086 1.3359312 2.6102858 2.4961126 0.024948271 0.010829745 0.16745637 0.015842788 0.008778201 50.0 150.0 Hmgcs2_29615 15360 hmgcs2 Linear 383.022 246.366 0.17927999696119257 1.6121778 1.6121778 -1.0162978 1.2141101 -1.0307788 1.3085654 1.6121778 0.9047663 0.18962832 0.8564502 0.04535118 1.8733683E-5 H1f0_29802 14958 h1f0 Linear 342.562 233.327 0.14233663778752215 -1.4318186 1.4318186 1.1104561 -1.0060751 -1.1720973 -1.1073208 -1.4318186 0.13862337 0.9518114 0.08766675 0.35532072 0.0025004463 Ccl7_30624 20306 ccl7 Linear 282.524 199.503 0.1548308105356253 2.4478195 2.4478195 1.1411624 1.3529519 1.0272148 1.4326189 2.4478195 0.48375612 0.12143568 0.86506176 0.006527629 0.0041368934 150.0 400.0 Dclk1_32007 13175 dclk1 Exp 5 319.712 28.6571 0.32620969810601996 1.8656378 1.8656378 1.2810284 1.3963698 1.1754755 1.8656378 1.758362 0.035655424 0.011634447 0.35736758 0.019983262 0.02761861 Nucb2_29574 53322 nucb2 Exp 5 210.525 0.23834 0.4346103222419705 1.9714434 1.9714434 1.3512626 1.428153 1.2650511 1.9714434 1.855738 0.029823886 0.012596121 0.19281633 0.040813833 0.0066378564