Curve Fit Prefilter Data Source: mouse_4D_KI_williams_0.05_NOMTC_nofoldfilter Work Source: mouse_4D_KI BMDExpress3 Version: BMDExpress 3.20.0119 BETA Timestamp (Start Time): 04/30/2025 12:24.22 Constant Variance: 1 BMR Factor: 2.0 Poly 2 BMR Factor: 5.0 Models Used: hill: Hill EPA BMDS MLE ToxicR,power: Power EPA BMDS MLE ToxicR,linear: Linear EPA BMDS MLE ToxicR,exponential 3: Exponential 3 EPA BMDS MLE ToxicR,exponential 5: Exponential 5 EPA BMDS MLE ToxicR, NOTEL/LOTEL Test: T-Test NOTEL/LOTEL p-Value Threshold: 0.05 NOTEL/LOTEL Fold Change Threshold: 2.0 Total Run Time: 12 seconds Williams Trend Test Data Source: mouse_4D_KI Work Source: null BMDExpress3 Version: BMDExpress 3.20.0119 BETA Timestamp (Start Time): 04/30/2025 12:14.38 Number of Permutations: 10000 Unadjusted P-Value Cutoff: 0.05 Multiple Testing Correction: false Filter Out Control Genes: true NOTEL/LOTEL Test: T-Test NOTEL/LOTEL p-Value Threshold: 0.05 NOTEL/LOTEL Fold Change Threshold: 2.0 Total Run Time: 21 seconds Chip: BioSpyder S1500_Mouse Provider: BioSpyder Chip File Creation Date: 10/31/24 Log Transformation: BASE2 BMDExpress3 Version: BMDExpress 3.20.0119 BETA Timestamp: 04/30/2025 12:11.51 Probe ID Gene ID Gene Symbol Best Model Best BMD Best BMDL Goodness of Fit Max Fold Change Max Fold Change Unsigned FC Dose Level 1 FC Dose Level 2 FC Dose Level 3 FC Dose Level 4 FC Dose Level 5 NOTEL/LOTEL T-Test p-Value Level 1 NOTEL/LOTEL T-Test p-Value Level 2 NOTEL/LOTEL T-Test p-Value Level 3 NOTEL/LOTEL T-Test p-Value Level 4 NOTEL/LOTEL T-Test p-Value Level 5 NOTEL LOTEL Atp1b1_31637 11931 atp1b1 Exp 5 344.725 81.0901 0.4751876580721367 1.1785897 1.1785897 -1.0549811 1.0612762 1.0880287 1.083911 1.1785897 0.3605486 0.21358505 0.20027559 0.043823082 9.665484E-4 Slc22a7_29397 108114 slc22a7 Power 390.69 333.476 0.15338854961541093 -1.4972489 1.4972489 1.3313615 1.2985553 1.0871699 1.1224452 -1.4972489 0.11944861 0.01723831 0.6278463 0.35110858 0.02271402 Htra1_30748 56213 htra1 Linear 183.82 139.511 0.291656935732744 -1.3675308 1.3675308 1.0558866 1.0126001 1.0136724 -1.0652812 -1.3675308 0.3110394 0.8036578 0.7988576 0.06966662 2.1132253E-6 Hsd3b3_31113 15494 hsd3b3 Linear 276.759 195.951 0.2490835851939568 2.485108 2.485108 1.2689434 1.3142276 1.2770414 1.5594486 2.485108 0.17836049 0.06861533 0.124366425 0.036350768 3.741856E-4 150.0 400.0 Timm9_30419 30056 timm9 Linear 324.094 219.437 0.6339144491946567 1.1249938 1.1249938 1.0156758 -1.0042808 1.022214 1.0732563 1.1249938 0.58521914 0.9157981 0.4593254 0.021912664 8.30825E-4 Dio1_31911 13370 dio1 Linear 322.622 220.13 9.139405396016986E-4 -1.438761 1.438761 1.4180732 1.165286 -1.0351107 1.011856 -1.438761 0.0017086731 0.108491406 0.68297476 0.9168084 0.0054706996 Dio1_31468 13370 dio1 Linear 299.316 208.75 0.006970496537411552 -1.5207285 1.5207285 1.3279846 1.2117587 -1.065596 -1.0219123 -1.5207285 0.07132491 0.029809529 0.49408057 0.8452553 5.6504575E-4 Ces1d_31073 104158 ces1d Exp 5 155.25 2.17125 0.9873444263389606 1.4537803 1.4537803 1.1020182 1.1405357 1.3603001 1.4537803 1.43518 0.3793343 0.2709007 0.011023613 0.009476891 0.010425103 Gsta1_31374 100042295 gsta13 Power 229.303 167.056 0.006104289930634832 2.8947 2.8947 -1.6686425 -1.3220471 -1.3359352 1.1518316 2.8947 0.009853108 0.05178628 0.13020974 0.33773825 4.2422434E-6 150.0 400.0 Dbp_31391 13170 dbp Linear 345.809 231.873 0.07620597973237087 3.3555708 3.3555708 -2.063359 -1.0766983 1.2855228 1.9074792 3.3555708 0.13554789 0.86470264 0.5304627 0.026295241 6.957435E-4 150.0 400.0 Comt_31082 12846 comt Power 397.794 309.933 0.7997065509416401 -1.2149229 1.2149229 1.0736784 1.0331041 -1.0007817 -1.0081446 -1.2149229 0.20036508 0.5903096 0.9932686 0.9075029 0.0010538334 Znrd1_29627 66136 polr1h Linear 384.212 245.816 0.09125342372807244 -1.1855706 1.1855706 -1.0298632 1.0388703 -1.0880142 -1.1317378 -1.1855706 0.5878568 0.46897137 0.065713726 0.05560495 0.0010979765 Nfil3_31222 18030 nfil3 Linear 327.93 221.683 0.20459116094410235 -2.0176737 2.0176737 1.2175825 -1.0232991 -1.2984663 -1.4871526 -2.0176737 0.39467534 0.9152144 0.24200313 0.010114164 5.5190463E-5 150.0 400.0 Wasf3_30108 245880 wasf3 Exp 3 394.437 282.688 0.3752180868720951 -1.3682617 1.3682617 -1.0318421 1.1087282 1.124398 -1.1108513 -1.3682617 0.70574117 0.31824327 0.23400435 0.3645115 0.035228204 Cyp2a5_31713 13087 cyp2a5 Linear 258.942 186.121 0.8778509297555745 2.0583138 2.0583138 1.0754806 -1.0225681 1.1332451 1.3396676 2.0583138 0.673646 0.87102914 0.4224064 0.058693174 5.4670305E-5 150.0 400.0 Rnf125_32252 67664 rnf125 Linear 368.099 242.547 0.5207348996327712 -1.6130157 1.6130157 1.0826374 -1.0932534 -1.1586251 -1.1672436 -1.6130157 0.59941024 0.46337825 0.35165852 0.14443758 0.004016915 Bhlhe40_31406 20893 bhlhe40 Linear 277.848 198.579 0.010972160091698324 1.3467958 1.3467958 -1.2216271 -1.0335419 1.0350631 1.076117 1.3467958 0.0027958243 0.69613034 0.674905 0.24458526 5.479414E-5 Cry1_31531 12952 cry1 Power 399.383 332.087 0.35645105564682933 1.7481986 1.7481986 1.1362212 -1.0802333 -1.0343022 -1.2603993 1.7481986 0.58032113 0.65649176 0.79518884 0.14283532 0.007346566 Phka1_31024 18679 phka1 Linear 362.255 236.66 0.3847997204120154 -1.2298976 1.2298976 1.0702771 1.0273865 -1.0642345 -1.0974461 -1.2298976 0.29994068 0.7464381 0.27662137 0.13475712 0.0028623708 Cyp4a10_31160 13117 cyp4a10 Hill 150.307 136.424 0.8661968125459311 1.815435 1.815435 1.0825297 -1.0018234 -1.1174976 1.549421 1.815435 0.5608132 0.98772615 0.39520755 0.05288601 2.9556447E-4 Acaa1a_29428 113868 acaa1a Exp 5 102.093 21.2839 0.9646668854629833 1.2117339 1.2117339 -1.0480975 -1.0046433 1.0519282 1.2117339 1.2075822 0.45312932 0.93920624 0.39562017 0.0075801807 0.0076916697 Hdac6_31734 15185 hdac6 Linear 330.78 223.319 0.0056693192344874355 -1.1797386 1.1797386 1.1623714 1.0552831 -1.0207194 -1.031463 -1.1797386 0.09100492 0.14101708 0.6175955 0.2627285 0.0051550516 Wdtc1_31549 230796 wdtc1 Linear 246.289 178.502 0.16429610789709082 -1.1905591 1.1905591 -1.0163199 1.0353684 1.0130092 -1.0925714 -1.1905591 0.6782103 0.3848333 0.7227573 0.008526911 4.310548E-5 Clpx_30931 270166 clpx Linear 361.587 236.698 0.00901857538449069 -1.3036232 1.3036232 1.2610781 1.0984578 -1.0543661 -1.0105503 -1.3036232 0.035452846 0.24407963 0.59622675 0.87253433 0.0012744945 Cdkn1a_30669 12575 cdkn1a Linear 352.314 231.761 0.12357745866782888 -1.859011 1.859011 1.1129398 -1.2950016 -1.014 -1.3518922 -1.859011 0.5380761 0.12875801 0.93708044 0.05072626 0.001792419 Hebp1_29916 15199 hebp1 Linear 381.921 248.939 0.38522523148826715 1.2362382 1.2362382 1.0060315 1.0898033 1.0272626 1.1030153 1.2362382 0.9068354 0.10746623 0.6380967 0.1969354 0.0012084902 Slc51a_29138 106407 slc51a Hill 92.1259 32.6524 0.9274397208065864 1.6655384 1.6655384 -1.1254096 1.05165 1.2756002 1.5180894 1.6655384 0.42290738 0.711167 0.07575178 0.0019869348 6.31202E-4 Ttr_31176 22139 ttr Exp 5 114.9 5.32331 0.2008286827059198 1.7206244 1.7206244 1.4109342 1.1349754 1.4280832 1.46083 1.7206244 0.004400363 0.19905938 0.0011851914 7.59222E-4 0.019686721 C920025E04RIK_30312 15040 h2-t23 Exp 3 399.363 323.023 0.17592881611298083 -1.193666 1.193666 1.0934857 -1.0436654 1.0629658 -1.0094355 -1.193666 0.21779422 0.48204106 0.35171854 0.8540798 0.0012753927 Gstp1_30795 14869 gstp2 Linear 361.666 240.141 0.5314758007732538 1.2252 1.2252 -1.0338215 1.0322433 -1.0144962 1.1103734 1.2252 0.53565335 0.43026167 0.6193238 0.30114943 0.009869276 Sh3bp5_29381 24056 sh3bp5 Linear 315.919 218.464 0.5297849654558793 -1.2715062 1.2715062 -1.0497817 1.014346 1.0007731 -1.0863513 -1.2715062 0.42202955 0.7410962 0.99109584 0.16020477 0.001497572 Gbp3_32192 55932 gbp3 Linear 370.971 242.423 6.54502342230856E-4 1.613274 1.613274 1.613274 1.2443119 1.1220001 -1.0719817 -1.376563 0.011642313 0.05368732 0.3309161 0.545857 0.010899341 Fabp1_29382 14080 fabp1 Linear 232.038 171.471 0.727518985746494 1.5276911 1.5276911 1.0248358 1.0437638 1.0082285 1.1566378 1.5276911 0.70509744 0.5349454 0.8959761 0.07531598 0.0033945553 Bdnf_30168 12064 bdnf Linear 368.878 245.554 0.002582663297222232 1.2402502 1.2402502 1.2402502 -1.0001051 1.0069247 -1.037768 -1.2278425 0.0025171523 0.9986291 0.9116674 0.5668125 0.02946869 Cyp4a14_29351 13119 cyp4a14 Linear 215.851 160.52 0.5382073218342066 2.2187877 2.2187877 1.0062118 1.035237 -1.0469819 1.3831403 2.2187877 0.9569176 0.7792782 0.7031116 0.1463485 3.785132E-5 150.0 400.0 Ndrg1_31127 17988 ndrg1 Linear 276.817 196.098 0.5716266692792904 -1.8824531 1.8824531 1.0042316 -1.1137903 -1.2346139 -1.3191037 -1.8824531 0.9725825 0.5171768 0.22140832 0.017053897 1.0479511E-6 Ces2e_30769 234673 ces2e Linear 311.472 214.977 0.05902545602901643 1.4116904 1.4116904 1.1068301 1.1239413 1.0453491 1.2874724 1.4116904 0.15887468 0.13550885 0.4734327 0.0012219223 0.003674058 Slc25a13_29322 50799 slc25a13 Linear 350.121 228.791 0.29072873064604154 1.258163 1.258163 1.0249482 1.086171 1.0783416 1.1642965 1.258163 0.67443967 0.16855271 0.1623569 0.02344449 0.0032900274 Nvl_30101 67459 nvl Linear 372.274 242.974 0.2904674083537172 -1.1629331 1.1629331 1.0025353 1.0258704 -1.0538944 -1.1149548 -1.1629331 0.970059 0.34509397 0.18559001 0.057581082 0.005836089 Hlf_30768 217082 hlf Linear 335.613 225.277 0.20163570002234088 1.6000657 1.6000657 -1.0934868 1.0326436 1.2451268 1.2821639 1.6000657 0.4565236 0.7937709 0.15424694 0.07667323 1.7048491E-4 Dnajb6_29809 23950 dnajb6 Power 371.844 281.411 0.9032071863408104 1.2423604 1.2423604 -1.0011469 1.0413125 1.0037047 1.0140543 1.2423604 0.98297375 0.36453497 0.9410211 0.8024891 1.9014976E-4 Cyp2e1_29238 13106 cyp2e1 Linear 348.472 231.2 0.07960774019117423 1.4544127 1.4544127 -1.1675884 1.0307432 -1.0141938 1.338308 1.4544127 0.20451075 0.7774523 0.89348775 0.050499983 0.0036563776 Chn1_30496 108699 chn1 Linear 399.197 253.548 0.22313492753940933 -1.906271 1.906271 -1.117245 -1.3236929 -1.3231136 -1.3194592 -1.906271 0.53925747 0.23290661 0.075213104 0.03412057 1.5686855E-4 Gsta2_31572 14858 gsta2 Linear 256.347 184.468 0.05186815257152522 1.4764103 1.4764103 -1.2082298 -1.1102588 -1.0730214 1.1990385 1.4764103 0.049403176 0.21195315 0.4924446 0.1281381 1.04004175E-4 Mapkapk2_30399 17164 mapkapk2 Linear 299.885 210.73 0.19801973347616686 -1.2067028 1.2067028 1.0812502 1.0349551 -1.0393978 -1.0527163 -1.2067028 0.24614309 0.38818082 0.4891024 0.22959891 2.4048907E-4 Cirbp_31851 12696 cirbp Linear 314.027 213.259 0.6511648145518095 -1.3602709 1.3602709 -1.0572276 1.0275958 -1.0421953 -1.1532552 -1.3602709 0.6042102 0.6984517 0.5954204 0.01374477 2.1297508E-4 Igfbp7_29447 29817 igfbp7 Linear 372.034 242.306 0.021123730636663063 -1.1007136 1.1007136 1.0212117 1.0094856 1.0702417 -1.0243332 -1.1007136 0.55824465 0.76111203 0.030847946 0.42065188 0.0061036428 Slc35f2_31469 72022 slc35f2 Exp 3 391.521 334.01 0.6452805445537244 -1.2353319 1.2353319 1.0853122 1.0796205 1.0810008 1.0414119 -1.2353319 0.17384525 0.32354647 0.25263855 0.64723986 0.029275963 Nr1h3_84180 22259 nr1h3 Linear 365.344 238.55 0.24273244534443938 -1.2133819 1.2133819 1.0061263 1.0671535 -1.0367467 -1.0105696 -1.2133819 0.8766366 0.13616164 0.5432834 0.8922828 0.0016160378 Igfbp3_31859 16009 igfbp3 Linear 309.444 213.761 0.02646590281672545 -1.3125064 1.3125064 -1.0767909 -1.0729129 -1.1467203 -1.079751 -1.3125064 0.15542029 0.06618413 0.0029500204 0.28652564 9.244958E-6 Gm3776_29765 14857 gsta1 Linear 224.377 165.624 0.04308526359426135 1.6622366 1.6622366 -1.2265339 -1.126232 -1.1331272 1.202063 1.6622366 0.044927347 0.17197803 0.28087154 0.1622781 4.6475583E-5 Ptprk_29229 19272 ptprk Linear 326.928 221.522 0.06593545694705161 -1.1517951 1.1517951 1.1026201 1.0360544 -1.0028346 -1.022343 -1.1517951 0.023826523 0.3785706 0.95286685 0.56536937 0.0047535514 Myh1_30160 17879 myh1 Power 395.29 387.063 0.398266659808998 -2.2050471 2.2050471 -1.127201 -1.1013803 -1.3329787 -1.0047464 -2.2050471 0.42216247 0.53439474 0.14607286 0.9814059 3.8631714E-4 150.0 400.0