Curve Fit Prefilter Data Source: mouse_4D_LU_williams_0.05_NOMTC_nofoldfilter Work Source: mouse_4D_LU BMDExpress3 Version: BMDExpress 3.20.0119 BETA Timestamp (Start Time): 04/30/2025 12:25.22 Constant Variance: 1 BMR Factor: 2.0 Poly 2 BMR Factor: 5.0 Models Used: hill: Hill EPA BMDS MLE ToxicR,power: Power EPA BMDS MLE ToxicR,linear: Linear EPA BMDS MLE ToxicR,exponential 3: Exponential 3 EPA BMDS MLE ToxicR,exponential 5: Exponential 5 EPA BMDS MLE ToxicR, NOTEL/LOTEL Test: T-Test NOTEL/LOTEL p-Value Threshold: 0.05 NOTEL/LOTEL Fold Change Threshold: 2.0 Total Run Time: 14 seconds Williams Trend Test Data Source: mouse_4D_LU Work Source: null BMDExpress3 Version: BMDExpress 3.20.0119 BETA Timestamp (Start Time): 04/30/2025 12:15.17 Number of Permutations: 10000 Unadjusted P-Value Cutoff: 0.05 Multiple Testing Correction: false Filter Out Control Genes: true NOTEL/LOTEL Test: T-Test NOTEL/LOTEL p-Value Threshold: 0.05 NOTEL/LOTEL Fold Change Threshold: 2.0 Total Run Time: 23 seconds Chip: BioSpyder S1500_Mouse Provider: BioSpyder Chip File Creation Date: 10/31/24 Log Transformation: BASE2 BMDExpress3 Version: BMDExpress 3.20.0119 BETA Timestamp: 04/30/2025 12:11.51 Probe ID Gene ID Gene Symbol Best Model Best BMD Best BMDL Goodness of Fit Max Fold Change Max Fold Change Unsigned FC Dose Level 1 FC Dose Level 2 FC Dose Level 3 FC Dose Level 4 FC Dose Level 5 NOTEL/LOTEL T-Test p-Value Level 1 NOTEL/LOTEL T-Test p-Value Level 2 NOTEL/LOTEL T-Test p-Value Level 3 NOTEL/LOTEL T-Test p-Value Level 4 NOTEL/LOTEL T-Test p-Value Level 5 NOTEL LOTEL Ugt1a7c_29171 94284 ugt1a6a Exp 5 1.82271 0.101916 0.96237519841905 1.6500561 1.6500561 1.3192778 1.3843609 1.6164103 1.5829234 1.6500561 1.0415265E-4 9.1150694E-4 2.016418E-5 0.004615627 0.015064465 Top2a_30844 21973 top2a Hill 3.17748 0.00271682 0.29440743194886676 1.9449936 1.9449936 1.4132804 1.5662066 1.9449936 1.553971 1.4023254 0.04069144 0.0018987647 0.003693764 0.007908436 0.029773502 Gsta1_31374 100042295 gsta13 Linear 364.61 240.873 0.041158638030511785 1.8317972 1.8317972 -1.1671859 1.0378351 1.4536914 1.2314942 1.8317972 0.26423654 0.8259864 0.083863705 0.2293957 1.601699E-5 Uhrf1_30587 18140 uhrf1 Hill 4.73155 0.140823 0.22766450591669196 1.7115148 1.7115148 1.1687714 1.4560562 1.7115148 1.2954271 1.540847 0.2593577 0.0011163328 9.0078265E-6 0.018283788 0.011398831 Dbp_31391 13170 dbp Linear 325.688 224.157 0.6250837614477414 4.9418535 4.9418535 -1.3995374 1.0347773 1.2190747 1.3317206 4.9418535 0.47068176 0.94041044 0.6913691 0.30346906 5.194826E-5 150.0 400.0 Bhlhe40_32105 20893 bhlhe40 Linear 307.021 212.574 0.37393548956973977 2.1521363 2.1521363 1.0341237 1.1863858 1.2082819 1.1701583 2.1521363 0.8201873 0.29189822 0.13258123 0.4152611 0.0010315595 150.0 400.0 Ccna1_31057 12427 ccna1 Exp 5 4.62462 2.18145 0.05224730017163637 2.7437017 2.7437017 1.4664204 2.3615506 2.697933 2.7437017 1.7457083 0.008652852 0.0011905046 1.2736155E-4 6.3436833E-4 0.02550983 1.0 10.0 Calcoco1_30287 67488 calcoco1 Power 395.133 307.73 0.6785487410297621 -1.250247 1.250247 1.0824703 1.0720891 -1.0076681 -1.0045065 -1.250247 0.19894017 0.17456825 0.90850776 0.9625288 0.046435304 Hells_29658 15201 hells Hill 5.60672 0.181754 0.5054129152036926 1.5096035 1.5096035 1.2248523 1.3238773 1.5096035 1.2719799 1.4590441 0.008374181 0.002908277 0.0021475083 0.038861964 0.011477895 Gpx2_31292 14777 gpx2-ps1 Exp 5 66.8688 7.62438 0.9862753730418132 1.5489944 1.5489944 1.1195097 1.1842391 1.4423296 1.4691714 1.5489944 0.25364017 0.09061058 5.8545545E-4 0.0116853975 0.013745923 Zwilch_31068 68014 zwilch Hill 8.64939 5.06117E-4 0.2724997756016314 1.657333 1.657333 1.3206139 1.3836842 1.657333 1.2729545 1.4767864 0.08382972 0.0012853545 6.054332E-4 0.03331509 0.02353209 Lcn2_30771 16819 lcn2 Power 371.382 302.606 0.9040697995413005 1.5166942 1.5166942 1.0090734 1.0888315 1.0142756 1.0465722 1.5166942 0.89233136 0.2531716 0.8547508 0.69184303 0.024748426 Vgll3_30283 73569 vgll3 Linear 375.816 245.89 0.33580050876250545 -1.3838769 1.3838769 1.1781819 1.0522808 -1.014008 -1.0545707 -1.3838769 0.10504712 0.5337932 0.905446 0.66463774 0.009429028 Igfbp3_31276 16009 igfbp3 Linear 318.086 217.754 0.3913199999484184 -1.541319 1.541319 1.1739088 1.1143581 -1.0390949 -1.1565491 -1.541319 0.07743909 0.2648451 0.77079296 0.12941915 0.049054362 Bhlhe40_31406 20893 bhlhe40 Linear 273.33 193.612 0.4127661791409327 1.9700762 1.9700762 -1.0503863 1.0805571 1.1480802 1.122058 1.9700762 0.7132994 0.5249427 0.31044078 0.44316122 1.152317E-4 Gins2_84152 272551 gins2 Hill 2.59614 0.447874 0.5562740376862496 1.7454786 1.7454786 1.2181295 1.489442 1.7454786 1.446439 1.524264 0.057983402 1.1046043E-5 0.001418266 0.0011716362 0.013933578 Cenpk_29938 60411 cenpk Hill 6.68409 0.140128 0.32447151864922996 1.6060449 1.6060449 1.2341117 1.3343236 1.6060449 1.2884567 1.4385123 0.03833955 0.005693285 0.0012050825 0.02829998 0.0047736685 Tspan4_30708 64540 tspan4 Linear 348.868 232.378 0.8392047911259988 1.951697 1.951697 1.044223 1.1355907 1.1877626 1.3958386 1.951697 0.835951 0.5448853 0.15756567 0.0679984 0.0011322544 Mthfd1l_32017 270685 mthfd1l Power 385.417 379.405 0.24430610613217418 2.0414996 2.0414996 1.0395755 1.1641625 1.1758845 1.0197273 2.0414996 0.6183187 0.22452176 0.03143351 0.8781044 1.956446E-6 150.0 400.0 Ifi44_29813 99899 ifi44 Linear 397.338 252.987 0.3695112555075927 -1.5574594 1.5574594 1.230784 1.0234357 -1.0180264 -1.2767986 -1.5574594 0.2812786 0.82053584 0.92833287 0.078476965 0.016259111 Loxl1_31479 16949 loxl1 Power 393.46 304.461 0.14553715001885126 -1.324381 1.324381 1.2451413 1.1753356 1.187988 1.0103 -1.324381 0.0970718 0.05495375 0.21508153 0.9268064 0.0142473625 Ugt1a6a_29170 394435 ugt1a6b Exp 5 3.5598 0.52634 0.849822628868377 1.7725545 1.7725545 1.2501701 1.4343325 1.5686767 1.7725545 1.5790764 0.008571237 3.588934E-4 2.872593E-4 1.0007559E-4 0.0032809519 F3_31194 14066 f3 Linear 389.249 250.232 0.4514004819302535 1.4619642 1.4619642 -1.0081134 -1.0901597 1.1084749 1.0551912 1.4619642 0.93786 0.3836749 0.40455043 0.5404559 0.023451243 Col12a1_30069 12816 col12a1 Linear 390.649 251.268 0.5333995162819829 1.5970916 1.5970916 1.0893377 1.1516947 1.0611415 1.1577332 1.5970916 0.41151455 0.19451739 0.6661572 0.12821896 0.021276431 Cdkn1a_30669 12575 cdkn1a Linear 315.566 217.236 0.839637301493989 -1.8807528 1.8807528 1.0706238 -1.0723783 -1.1291597 -1.3210344 -1.8807528 0.6980226 0.66260135 0.39119074 0.0884628 0.0019100504 Slc7a11_30093 26570 slc7a11 Hill 52.6611 0.331799 0.2836895824734177 2.4843912 2.4843912 1.2061865 1.3411634 1.6138785 2.4843912 2.130693 0.051083505 0.009515704 0.00328551 0.0013699991 0.00930097 50.0 150.0 Pole_31952 18973 pole Hill 5.99036 0.0103333 0.5094752588092543 1.6657664 1.6657664 1.2134424 1.4833714 1.6657664 1.3192884 1.5894825 0.1617762 2.338196E-4 6.5597286E-4 0.11031744 1.2756062E-4 Ube2t_30503 67196 ube2t Exp 5 10.7991 1.2674 0.09903512800741943 1.8300062 1.8300062 1.0920453 1.4956641 1.8300062 1.619226 1.272536 0.3720087 7.4845484E-5 0.0029827822 0.0142434165 0.02395187 Lox_31402 16948 lox Linear 360.542 238.239 0.6471188377359897 -1.745979 1.745979 -1.0573615 -1.1041938 -1.2389826 -1.2434502 -1.745979 0.62032014 0.43162736 0.10509258 0.14733464 0.017153298 Atp2b2_32103 11941 atp2b2 Exp 5 55.217 0.0268941 0.05284143055854473 1.8271699 1.8271699 1.2911547 1.8271699 1.7086809 1.3136696 1.7002727 0.016876964 6.527376E-5 2.4088868E-4 0.083502606 0.0039276867 Nqo1_29503 18104 nqo1 Exp 5 5.7078 1.12535 0.38891032913931667 2.33548 2.33548 1.3296767 1.4118471 1.8076556 2.33548 2.0823648 0.01020306 1.2771827E-4 3.7244073E-4 0.0010142607 5.733752E-4 50.0 150.0 Nrcam_32153 319504 nrcam Power 395.691 318.764 0.6438802963132217 -1.3970293 1.3970293 1.1638072 1.0732768 1.1147492 1.0012019 -1.3970293 0.1892946 0.3401589 0.41251984 0.9940961 0.014480954 Adm_30365 11535 adm Power 315.44 239.362 0.33203191621125105 -2.523845 2.523845 1.308809 1.3879405 1.1054295 1.0062188 -2.523845 0.16180056 0.108043544 0.7205868 0.961922 3.9197446E-5 150.0 400.0 Igha_32269 Power 399.027 389.65 0.8549303518116905 -1.7634382 1.7634382 1.0149261 1.1509924 -1.049222 1.0630536 -1.7634382 0.9462981 0.24508186 0.7757561 0.6545786 0.031777114 Chn1_31954 108699 chn1 Power 394.086 386.242 0.35931191576520893 1.508737 1.508737 1.1475427 1.0804003 1.0356377 -1.0086409 1.508737 0.090235755 0.34820926 0.6991396 0.92628586 1.85631E-4 Nap1l5_31694 58243 nap1l5 Linear 351.633 234.089 0.7173712173654236 -1.557351 1.557351 -1.0570879 -1.0813435 -1.003117 -1.2063344 -1.557351 0.72523564 0.28362086 0.98117185 0.1247516 2.6482355E-4 Cyp1a1_29719 13076 cyp1a1 Linear 152.143 119.016 0.6929735633124241 -5.0073385 5.0073385 -1.0783597 -1.1583617 -1.4470736 -1.8235397 -5.0073385 0.7490418 0.3768977 0.060588807 4.619997E-5 1.5349996E-4 150.0 400.0 Rad51_31623 19361 rad51 Exp 5 3.73263 0.00182733 0.03866763860887246 1.9498307 1.9498307 1.3106861 1.597658 1.9498307 1.4860888 1.5301173 0.038771026 3.1826357E-7 4.108024E-5 0.024239253 0.0060541118 Hlf_30768 217082 hlf Exp 3 323.52 246.864 0.9294152655869875 3.0036716 3.0036716 -1.1190772 -1.1717683 -1.0029987 1.0732282 3.0036716 0.5553345 0.556014 0.9919575 0.64044964 4.23739E-6 150.0 400.0 Cks1b_31964 624855 cks1brt Hill 19.989 9.27076E-11 0.32051416236686514 1.4636751 1.4636751 1.1624874 1.3385717 1.4636751 1.1979876 1.4404278 0.13352795 3.2668022E-4 0.0012742329 0.029310618 0.015690053 Gclc_31268 14629 gclc Exp 5 380.131 256.579 0.960068081738436 1.3993737 1.3993737 1.0748512 1.0848191 1.1390473 1.3576746 1.3993737 0.41439277 0.40786543 0.12602301 0.006760187 0.07107454 Gsta2_31572 14858 gsta2 Exp 5 21.4173 0.570463 0.591308689845421 2.0557609 2.0557609 1.2937261 1.4048804 1.5506351 1.5084256 2.0557609 0.022918383 0.005888507 6.954861E-5 0.020958306 2.58047E-4 150.0 400.0 Ccl2_30705 20296 ccl2 Linear 324.593 221.453 0.46874868978975714 2.636642 2.636642 1.0333152 1.299593 1.1611415 1.2724938 2.636642 0.85233456 0.35568473 0.22983226 0.12373517 0.016205406 150.0 400.0 Aldh1a1_29991 11668 aldh1a1 Exp 5 201.244 3.88845 0.9991855145555798 1.4702274 1.4702274 1.067737 1.1228226 1.3205464 1.4504983 1.4702274 0.45359135 0.3245809 0.022682639 0.030110061 0.0056499527 Hmgcs2_29615 15360 hmgcs2 Linear 236.063 172.687 0.5510716255781818 -1.9133992 1.9133992 1.1124433 -1.046333 -1.0831102 -1.1771349 -1.9133992 0.385445 0.48704192 0.55328393 0.2503193 0.0031958795 Lgals1_29720 16852 lgals1 Linear 351.822 232.569 0.714720314237836 1.5709985 1.5709985 -1.0352658 1.0327839 1.0762792 1.0758545 1.5709985 0.6730997 0.6863457 0.5618654 0.44113058 0.047743138 Ces1g_30475 12623 ces1g Exp 5 0.260878 0.0306323 0.9997471225796936 3.7703822 3.7703822 1.8519841 2.5884457 3.302021 3.4776027 3.7703822 2.0216223E-4 1.416067E-6 2.6020822E-7 6.85275E-6 3.6869867E-5 1.0 10.0 Igfbp3_31859 16009 igfbp3 Linear 298.678 208.375 0.6494547716631857 -1.6959802 1.6959802 1.0704865 1.1024934 -1.054942 -1.1085472 -1.6959802 0.4694314 0.33843 0.6626967 0.5212822 0.011281902 Gm3776_29765 14857 gsta1 Exp 5 39.5509 12.2168 0.10131205353552908 2.2273088 2.2273088 1.342727 1.2220078 1.7008519 1.5077457 2.2273088 0.015538143 0.062145703 5.987654E-6 0.018745732 6.8103673E-4 150.0 400.0 Ccl7_30624 20306 ccl7 Linear 393.678 253.04 0.15919031810459217 2.655927 2.655927 -1.3763031 1.2740909 1.1601722 1.0888814 2.655927 0.32157257 0.40975204 0.23800446 0.44709846 0.059651457 Tubb6_30743 67951 tubb6 Linear 355.378 236.787 0.06918202236688042 1.4761552 1.4761552 -1.005367 1.1757859 1.1064205 1.0660465 1.4761552 0.9526508 0.07592881 0.17145032 0.2826943 0.014350882 Tspan4_32011 64540 tspan4 Linear 308.581 212.974 0.666575940421265 2.0494413 2.0494413 1.0225215 1.007509 1.0075883 1.1276481 2.0494413 0.87047017 0.96197146 0.96655726 0.38523483 0.0048030787 150.0 400.0 Tsku_29473 244152 tsku Exp 5 160.501 7.05005 0.999830388957907 1.6786829 1.6786829 1.2092603 1.357672 1.493779 1.5301516 1.6786829 0.06419547 0.06840998 0.010607349 0.02063689 0.015206987 Itgae_31885 16407 itgae Linear 377.294 247.071 0.5005668469344142 -1.288502 1.288502 1.0438628 1.0707735 1.0211054 -1.0128254 -1.288502 0.5863139 0.3673035 0.7258038 0.8835668 0.036820326 Rad54b_30165 623474 rad54b Hill 0.985329 0.262638 0.9128458305236076 1.6678222 1.6678222 1.4626825 1.6678222 1.606202 1.4966274 1.4757149 0.04310584 1.9006506E-5 0.0041712113 0.0036694615 5.0289143E-4 Ccl17_30059 20295 ccl17 Power 399.712 390.089 0.179054921633097 1.4400941 1.4400941 -1.2561362 -1.2251722 -1.3326342 -1.2197902 1.4400941 0.05606044 0.21595733 4.5128698E-5 0.18432316 0.16657299 Dtl_29371 76843 dtl Hill 1.578 0.451334 0.12771505444195708 2.6029103 2.6029103 1.4652323 1.8276854 2.6029103 2.0416312 1.8129212 0.018478693 1.08540924E-4 1.6268543E-5 7.972973E-4 0.0017517031 10.0 50.0