Curve Fit Prefilter Data Source: mouse_4D_OV_williams_0.05_NOMTC_nofoldfilter Work Source: mouse_4D_OV BMDExpress3 Version: BMDExpress 3.20.0119 BETA Timestamp (Start Time): 04/30/2025 12:25.36 Constant Variance: 1 BMR Factor: 2.0 Poly 2 BMR Factor: 5.0 Models Used: hill: Hill EPA BMDS MLE ToxicR,power: Power EPA BMDS MLE ToxicR,linear: Linear EPA BMDS MLE ToxicR,exponential 3: Exponential 3 EPA BMDS MLE ToxicR,exponential 5: Exponential 5 EPA BMDS MLE ToxicR, NOTEL/LOTEL Test: T-Test NOTEL/LOTEL p-Value Threshold: 0.05 NOTEL/LOTEL Fold Change Threshold: 2.0 Total Run Time: 12 seconds Williams Trend Test Data Source: mouse_4D_OV Work Source: null BMDExpress3 Version: BMDExpress 3.20.0119 BETA Timestamp (Start Time): 04/30/2025 12:15.41 Number of Permutations: 10000 Unadjusted P-Value Cutoff: 0.05 Multiple Testing Correction: false Filter Out Control Genes: true NOTEL/LOTEL Test: T-Test NOTEL/LOTEL p-Value Threshold: 0.05 NOTEL/LOTEL Fold Change Threshold: 2.0 Total Run Time: 23 seconds Chip: BioSpyder S1500_Mouse Provider: BioSpyder Chip File Creation Date: 10/31/24 Log Transformation: BASE2 BMDExpress3 Version: BMDExpress 3.20.0119 BETA Timestamp: 04/30/2025 12:11.51 Probe ID Gene ID Gene Symbol Best Model Best BMD Best BMDL Goodness of Fit Max Fold Change Max Fold Change Unsigned FC Dose Level 1 FC Dose Level 2 FC Dose Level 3 FC Dose Level 4 FC Dose Level 5 NOTEL/LOTEL T-Test p-Value Level 1 NOTEL/LOTEL T-Test p-Value Level 2 NOTEL/LOTEL T-Test p-Value Level 3 NOTEL/LOTEL T-Test p-Value Level 4 NOTEL/LOTEL T-Test p-Value Level 5 NOTEL LOTEL Hoxa10_31922 15395 hoxa10 Power 398.565 328.081 0.8068857317845832 2.7495284 2.7495284 -1.3252022 1.1162477 -1.1125135 1.0668329 2.7495284 0.07327035 0.6597292 0.7450369 0.8660338 0.058086235 Clu_30840 12759 clu Linear 365.424 243.934 0.009896390787628051 -1.2056074 1.2056074 1.1810565 1.0794392 -1.0469896 -1.0777366 -1.2056074 0.005719785 0.12891364 0.5342084 0.3042344 0.0039555035 Dbp_31391 13170 dbp Linear 268.426 192.484 0.1662306801471567 2.1662118 2.1662118 -1.3794724 -1.0882102 1.1240354 1.3189176 2.1662118 0.09198379 0.50521094 0.67790073 0.013798512 2.6473857E-5 150.0 400.0 Sytl2_29612 83671 sytl2 Power 399.819 390.156 0.1726809551920252 -1.2009689 1.2009689 1.0819799 1.0040342 1.1078048 1.1286604 -1.2009689 0.28370166 0.9242298 0.083635315 0.20022698 0.017752862 Akap8l_31490 54194 akap8l Linear 324.654 220.747 0.058448954239852524 -1.2420096 1.2420096 -1.0155704 -1.0875382 1.015414 -1.0567567 -1.2420096 0.6667197 0.06172932 0.7490078 0.1232474 0.0057511674 Calcoco1_30287 67488 calcoco1 Linear 393.357 252.989 0.44312400113910877 -1.1985995 1.1985995 1.0938866 1.0321689 1.0216743 -1.043886 -1.1985995 0.098403074 0.61695194 0.8078781 0.3826042 0.007747227 Gpr137b-ps_84207 83924 gpr137b Power 393.68 385.944 0.5028083115155825 -1.2045009 1.2045009 -1.0420657 1.0322801 -1.0197539 -1.0005634 -1.2045009 0.31909916 0.5218343 0.6047801 0.99010855 6.918517E-6 Wipi1_84145 52639 wipi1 Linear 379.615 248.07 0.4016298376276075 -1.2107726 1.2107726 1.0552454 1.0073369 -1.0150174 -1.0032275 -1.2107726 0.38790226 0.900504 0.7501654 0.9525976 0.005537212 Klhl24_30498 75785 klhl24 Power 398.489 389.299 0.26655560103098574 -1.2559817 1.2559817 -1.089301 -1.0561596 -1.0691336 1.0045922 -1.2559817 0.16802979 0.3944084 0.18261343 0.90013933 0.0022027248 Use1_31822 67023 use1 Power 399.867 390.185 0.009459894978076644 -1.1733449 1.1733449 -1.0931472 -1.0777622 -1.0245851 1.016467 -1.1733449 0.0057553016 0.0064517437 0.5236024 0.4581605 0.019402996 H2-q6_31131 110557 h2-q6 Linear 371.995 244.048 0.2210592232849672 -1.5522662 1.5522662 -1.1465425 1.1076294 -1.0082293 -1.1570011 -1.5522662 0.15062451 0.38993606 0.94087535 0.21318154 0.025831612 Tuba4a_29527 22145 tuba4a Power 399.92 390.193 0.9493912805134036 1.5166767 1.5166767 -1.0399566 -1.0434382 -1.108324 -1.0539491 1.5166767 0.77408266 0.6688756 0.41677555 0.70333534 0.06580853 Hmgcs2_29615 15360 hmgcs2 Linear 354.502 234.785 0.2213779694458623 -1.3982576 1.3982576 1.0806301 1.0163629 -1.1209733 -1.0341318 -1.3982576 0.416078 0.79345876 0.2529705 0.73051006 0.0072138156 Cirbp_31851 12696 cirbp Linear 333.067 226.131 0.3415380540000441 -1.2919803 1.2919803 -1.0198328 -1.0957531 -1.0199933 -1.1050514 -1.2919803 0.69290763 0.19404404 0.7640689 0.035100874 0.0012601708 Gdf7_29562 238057 gdf7 Linear 347.771 232.266 0.14113587148090656 5.0911355 5.0911355 -1.824637 1.3084817 -1.1956717 1.189914 5.0911355 0.03529487 0.26454583 0.61978585 0.65743816 0.06380137 Cyp2a4_30021 13086 cyp2a4 Linear 365.906 240.978 0.2172307171914183 1.9678746 1.9678746 -1.3921385 -1.2733325 1.0530589 1.4251522 1.9678746 0.08575234 0.34087467 0.83890426 0.086221665 0.017491037