One-way ANOVA Data Source: mouse_4D_KI Work Source: null BMDExpress3 Version: BMDExpress 3.20.0129 BETA Timestamp (Start Time): 08/14/2025 10:45.29 Adjusted P-Value Cutoff: 0.05 Multiple Testing Correction: true Filter Out Control Genes: true NOTEL/LOTEL Test: T-Test NOTEL/LOTEL p-Value Threshold: 0.05 NOTEL/LOTEL Fold Change Threshold: 2.0 Total Run Time: 0 seconds Chip: BioSpyder S1500_Mouse Provider: BioSpyder Chip File Creation Date: 10/31/24 Log Transformation: BASE2 BMDExpress3 Version: BMDExpress 3.20.0119 BETA Timestamp: 05/15/2025 16:55.12 Probe ID Gene ID Gene Symbol Df1 Df2 F-Value Unadjusted P-Value Adjusted P-Value Max Fold Change Max Fold Change Unsigned FC Dose Level 1 FC Dose Level 2 FC Dose Level 3 FC Dose Level 4 FC Dose Level 5 NOTEL/LOTEL T-Test p-Value Level 1 NOTEL/LOTEL T-Test p-Value Level 2 NOTEL/LOTEL T-Test p-Value Level 3 NOTEL/LOTEL T-Test p-Value Level 4 NOTEL/LOTEL T-Test p-Value Level 5 NOTEL LOTEL Htra1_30748 56213 htra1 5 21 15.63348379210244 1.8310590231829238E-6 0.002255864716561362 -1.3880024 1.3880024 1.0580134 1.0151489 -1.0159451 -1.1027324 -1.3880024 0.3717537 0.795366 0.80404943 0.004278282 4.429815E-6 Dio1_31911 13370 dio1 5 21 8.091644003098647 2.193002689367951E-4 0.04043225691805006 1.5000514 1.5000514 1.5000514 1.273664 1.0222721 1.073446 -1.3578712 0.0071452125 0.055809975 0.845026 0.6382755 0.025242494 Dio1_31468 13370 dio1 5 21 7.947918895468709 2.4613792766670084E-4 0.04043225691805006 -1.4443446 1.4443446 1.4077336 1.3173618 -1.0261648 -1.0140493 -1.4443446 0.10298424 0.025138976 0.8313542 0.9171751 0.007980729 Gsta1_31374 100042295 gsta13 5 21 18.08421188082888 5.602125374704059E-7 0.0013803636923270801 2.738643 2.738643 -1.669867 -1.4443477 -1.3167279 1.0983623 2.738643 0.04497689 0.08758842 0.2548332 0.6549004 0.0011543114 150.0 400.0 Bhlhe40_31406 20893 bhlhe40 5 21 10.211671702862512 4.543796000999745E-5 0.0159941619235191 1.3231157 1.3231157 -1.2714533 -1.0244247 1.0090193 1.0431733 1.3231157 9.887336E-4 0.80109274 0.92732596 0.52534086 1.6087378E-4 Slc10a2_29328 20494 slc10a2 5 21 7.845506136159661 2.6744336424389115E-4 0.041186278093559237 1.5911603 1.5911603 1.5911603 1.2694881 1.2054855 1.1001062 -1.0385023 2.4180558E-4 0.018959183 0.06916971 0.31342435 0.7236687 Hdac6_31734 15185 hdac6 5 21 11.065655221168118 2.558378008632456E-5 0.010506405688783952 1.2034205 1.2034205 1.2034205 1.0215402 -1.0400642 -1.0503162 -1.1958233 0.054155648 0.5128156 0.45582193 0.14790714 0.0038812377 Wdtc1_31549 230796 wdtc1 5 21 12.815392936435412 8.613829234449533E-6 0.007074825077894549 -1.2106458 1.2106458 -1.0125104 1.0422838 -1.0008336 -1.1238841 -1.2106458 0.7587064 0.29178047 0.98539025 0.006861879 3.8564898E-4 Gbp3_32192 55932 gbp3 5 21 11.43498384330245 2.0141295300701856E-5 0.009925630324185874 1.8464543 1.8464543 1.8464543 1.3250496 1.1016512 1.0372642 -1.3132523 0.0041778544 0.065698005 0.44984898 0.77594304 0.06479963 Fabp1_29382 14080 fabp1 5 21 7.959665834011516 2.4381510362547765E-4 0.04043225691805006 1.5695267 1.5695267 1.0467328 1.0447875 1.0489007 1.2134396 1.5695267 0.572119 0.57730675 0.53391254 0.06266895 0.002478029 Bdnf_30168 12064 bdnf 5 21 8.8491328267387 1.2168095829556691E-4 0.03747773515503461 1.2445854 1.2445854 1.2445854 1.0379357 -1.0526732 -1.0170954 -1.240363 0.01012827 0.4352046 0.30053207 0.81537014 0.023922805 Cyp4a14_29351 13119 cyp4a14 5 21 7.96796366065124 2.4218872571157846E-4 0.04043225691805006 2.0910652 2.0910652 -1.0506252 -1.0056971 -1.0551537 1.1855056 2.0910652 0.76825404 0.97411853 0.73966855 0.4957533 0.0041410164 150.0 400.0 Gsta2_31572 14858 gsta2 5 21 8.320158164285512 1.8297724772298185E-4 0.04043225691805006 1.4467857 1.4467857 -1.2933235 -1.1435516 -1.0417992 1.1671408 1.4467857 0.03681896 0.26078898 0.73796725 0.32271928 0.007704823 Ces1g_30475 12623 ces1g 5 21 7.995968156136724 2.3678665574433655E-4 0.04043225691805006 1.8127007 1.8127007 -1.0012623 1.2808233 1.7087632 1.8127007 1.4798936 0.9885511 0.015415833 0.026633233 0.008355866 0.009136082 Gm3776_29765 14857 gsta1 5 21 11.492937461440663 1.940868008432073E-5 0.009925630324185874 1.5881786 1.5881786 -1.3419911 -1.198733 -1.1085373 1.1351011 1.5881786 0.031649258 0.14384343 0.4063441 0.45312893 0.0043347287 Tsku_29473 244152 tsku 5 21 8.044837735230603 2.2767203249929313E-4 0.04043225691805006 -1.9775143 1.9775143 -1.9775143 -1.4408026 -1.1699528 -1.0062718 1.1305606 1.6100357E-4 0.034902778 0.39483508 0.9561459 0.40578258