One-way ANOVA Data Source: mouse_4D_LU Work Source: null BMDExpress3 Version: BMDExpress 3.20.0129 BETA Timestamp (Start Time): 08/14/2025 10:45.26 Adjusted P-Value Cutoff: 0.05 Multiple Testing Correction: true Filter Out Control Genes: true NOTEL/LOTEL Test: T-Test NOTEL/LOTEL p-Value Threshold: 0.05 NOTEL/LOTEL Fold Change Threshold: 2.0 Total Run Time: 0 seconds Chip: BioSpyder S1500_Mouse Provider: BioSpyder Chip File Creation Date: 10/31/24 Log Transformation: BASE2 BMDExpress3 Version: BMDExpress 3.20.0119 BETA Timestamp: 04/30/2025 12:11.51 Probe ID Gene ID Gene Symbol Df1 Df2 F-Value Unadjusted P-Value Adjusted P-Value Max Fold Change Max Fold Change Unsigned FC Dose Level 1 FC Dose Level 2 FC Dose Level 3 FC Dose Level 4 FC Dose Level 5 NOTEL/LOTEL T-Test p-Value Level 1 NOTEL/LOTEL T-Test p-Value Level 2 NOTEL/LOTEL T-Test p-Value Level 3 NOTEL/LOTEL T-Test p-Value Level 4 NOTEL/LOTEL T-Test p-Value Level 5 NOTEL LOTEL Ccnb1_31979 268697 ccnb1 5 29 8.835461078689226 3.4829730033658635E-5 0.004647019243964455 1.9112657 1.9112657 1.2619835 1.5883241 1.9112657 1.4068475 1.0798981 0.087497406 4.9789815E-4 0.001425375 0.025834803 0.42567682 Ugt1a7c_29171 94284 ugt1a6a 5 29 11.404778961046883 3.7868020821285597E-6 7.999619398496582E-4 1.6500561 1.6500561 1.3192778 1.3843609 1.6164103 1.5829234 1.6500561 1.0415265E-4 9.1150694E-4 2.016418E-5 0.004615627 0.015064465 Cdca2_30028 108912 cdca2 5 29 6.374898902719613 4.156329018146776E-4 0.029267483502783544 1.7474072 1.7474072 1.2846037 1.4058751 1.7474072 1.2334328 1.3218656 0.07905105 0.003674935 0.0033305483 0.0058175675 0.047192615 Kif2c_31481 73804 kif2c 5 29 6.235678068914304 4.8424656322554327E-4 0.03230434309938821 1.7574841 1.7574841 1.6342434 1.4517235 1.7574841 1.4313388 1.2442019 0.006073015 0.006984058 0.0033177927 0.0016023275 0.11772842 Top2a_30844 21973 top2a 5 29 6.965189539070944 2.209398906297677E-4 0.019313193887809006 1.9449936 1.9449936 1.4132804 1.5662066 1.9449936 1.553971 1.4023254 0.04069144 0.0018987647 0.003693764 0.007908436 0.029773502 Gsta1_31374 100042295 gsta13 5 29 5.699273641029208 8.847432750292983E-4 0.049840537826650474 1.8317972 1.8317972 -1.1671859 1.0378351 1.4536914 1.2314942 1.8317972 0.26423654 0.8259864 0.083863705 0.2293957 1.601699E-5 Uhrf1_30587 18140 uhrf1 5 29 8.381735650204181 5.344358197645338E-5 0.005890412187404753 1.7115148 1.7115148 1.1687714 1.4560562 1.7115148 1.2954271 1.540847 0.2593577 0.0011163328 9.0078265E-6 0.018283788 0.011398831 Zwilch_32048 68014 zwilch 5 29 5.923953841153023 6.854648371235061E-4 0.04137269909781162 1.7552153 1.7552153 1.4806569 1.3057486 1.7552153 1.4431673 1.299003 8.934343E-4 0.029806664 2.6810754E-4 0.014671217 0.103649676 Mthfd1l_31363 270685 mthfd1l 5 29 7.2549851417333056 1.634889627600833E-4 0.01594017386910812 1.598794 1.598794 1.3192594 1.1293645 1.3446438 -1.1785206 1.598794 0.04691338 0.35818276 0.013164278 0.11566767 0.0017575184 Ccna1_31057 12427 ccna1 5 29 15.710147399926694 1.6952802373015885E-7 8.595070803119054E-5 2.7437017 2.7437017 1.4664204 2.3615506 2.697933 2.7437017 1.7457083 0.008652852 0.0011905046 1.2736155E-4 6.3436833E-4 0.02550983 1.0 10.0 Hells_29658 15201 hells 5 29 6.788212278386916 2.663193976093492E-4 0.02109748977936563 1.5096035 1.5096035 1.2248523 1.3238773 1.5096035 1.2719799 1.4590441 0.008374181 0.002908277 0.0021475083 0.038861964 0.011477895 Gpx2_31292 14777 gpx2-ps1 5 29 5.742089318609058 8.424843026783035E-4 0.04853858425657953 1.5489944 1.5489944 1.1195097 1.1842391 1.4423296 1.4691714 1.5489944 0.25364017 0.09061058 5.8545545E-4 0.0116853975 0.013745923 Zwilch_31068 68014 zwilch 5 29 6.7898115081781745 2.6586755767088466E-4 0.02109748977936563 1.657333 1.657333 1.3206139 1.3836842 1.657333 1.2729545 1.4767864 0.08382972 0.0012853545 6.054332E-4 0.03331509 0.02353209 Bhlhe40_31406 20893 bhlhe40 5 29 6.839311539730254 2.5227763175461604E-4 0.02109748977936563 1.9700762 1.9700762 -1.0503863 1.0805571 1.1480802 1.122058 1.9700762 0.7132994 0.5249427 0.31044078 0.44316122 1.152317E-4 Prc1_29718 233406 prc1 5 29 7.508874583485992 1.2616939981668907E-4 0.012793577141412271 1.841285 1.841285 1.1781496 1.4890649 1.841285 1.4498876 1.2349544 0.18470846 3.210278E-4 0.004032471 0.0038415072 0.1376474 Pif1_30879 208084 pif1 5 29 6.0081525247507095 6.235881460804338E-4 0.03951989875784749 1.6974914 1.6974914 1.4004666 1.4170859 1.6974914 1.3805721 -1.0262032 0.04413822 0.010742115 0.0016582983 0.012881787 0.81256986 Gins2_84152 272551 gins2 5 29 9.83170625646177 1.4165084812223228E-5 0.0023938993332657255 1.7454786 1.7454786 1.2181295 1.489442 1.7454786 1.446439 1.524264 0.057983402 1.1046043E-5 0.001418266 0.0011716362 0.013933578 Cenpk_29938 60411 cenpk 5 29 7.217979132033479 1.6984358609428707E-4 0.015946425583296953 1.6060449 1.6060449 1.2341117 1.3343236 1.6060449 1.2884567 1.4385123 0.03833955 0.005693285 0.0012050825 0.02829998 0.0047736685 Cdc20_30847 107995 cdc20 5 29 13.397148220183782 8.291547802796728E-7 2.627384210011213E-4 2.0560272 2.0560272 1.3414048 1.6247059 2.0560272 1.6907499 1.1098161 0.04049313 4.2166785E-4 0.0020809479 0.0027195509 0.255334 10.0 50.0 Ccnb2_29477 12442 ccnb2 5 29 5.953882847154405 6.627545727984074E-4 0.040977630293755195 1.7162936 1.7162936 1.1117074 1.4506906 1.7162936 1.2990463 1.089101 0.40881097 0.009920473 0.0016198868 0.058726877 0.4226297 Mthfd1l_32017 270685 mthfd1l 5 29 13.615269750854562 7.085364456260734E-7 2.627384210011213E-4 2.0414996 2.0414996 1.0395755 1.1641625 1.1758845 1.0197273 2.0414996 0.6183187 0.22452176 0.03143351 0.8781044 1.956446E-6 150.0 400.0 Ugt1a6a_29170 394435 ugt1a6b 5 29 12.220106594117832 1.9958253498764122E-6 5.059417261936705E-4 1.7725545 1.7725545 1.2501701 1.4343325 1.5686767 1.7725545 1.5790764 0.008571237 3.588934E-4 2.872593E-4 1.0007559E-4 0.0032809519 Plk1_29780 18817 plk1 5 29 6.175792854936257 5.173762088063194E-4 0.03362945357241076 1.6337507 1.6337507 1.1364719 1.3778657 1.6337507 1.3499702 -1.0620337 0.4139302 0.02360189 1.326381E-4 0.053850513 0.38904786 Slc7a11_30093 26570 slc7a11 5 29 11.511724689826808 3.4761476453981643E-6 7.999619398496582E-4 2.4843912 2.4843912 1.2061865 1.3411634 1.6138785 2.4843912 2.130693 0.051083505 0.009515704 0.00328551 0.0013699991 0.00930097 50.0 150.0 Pole_31952 18973 pole 5 29 6.450457364364898 3.82791241524294E-4 0.028540464625414274 1.6657664 1.6657664 1.2134424 1.4833714 1.6657664 1.3192884 1.5894825 0.1617762 2.338196E-4 6.5597286E-4 0.11031744 1.2756062E-4 Ube2t_30503 67196 ube2t 5 29 9.083720064898149 2.7693937239781086E-5 0.004129654758990886 1.8300062 1.8300062 1.0920453 1.4956641 1.8300062 1.619226 1.272536 0.3720087 7.4845484E-5 0.0029827822 0.0142434165 0.02395187 Atp2b2_32103 11941 atp2b2 5 29 8.456314966657274 4.9770282428140966E-5 0.005734893907060789 1.8271699 1.8271699 1.2911547 1.8271699 1.7086809 1.3136696 1.7002727 0.016876964 6.527376E-5 2.4088868E-4 0.083502606 0.0039276867 Nqo1_29503 18104 nqo1 5 29 20.92568381209253 8.009440555234448E-9 1.0151965903759663E-5 2.33548 2.33548 1.3296767 1.4118471 1.8076556 2.33548 2.0823648 0.01020306 1.2771827E-4 3.7244073E-4 0.0010142607 5.733752E-4 50.0 150.0 Adm_30365 11535 adm 5 29 9.190278395589342 2.5125054261110336E-5 0.003980750784494669 -2.523845 2.523845 1.308809 1.3879405 1.1054295 1.0062188 -2.523845 0.16180056 0.108043544 0.7205868 0.961922 3.9197446E-5 150.0 400.0 Chn1_31954 108699 chn1 5 29 6.270845821161972 4.658481390630298E-4 0.03191689277094001 1.508737 1.508737 1.1475427 1.0804003 1.0356377 -1.0086409 1.508737 0.090235755 0.34820926 0.6991396 0.92628586 1.85631E-4 Cyp1a1_29719 13076 cyp1a1 5 29 19.913127921491707 1.3812132326762594E-8 1.1671251816114392E-5 -5.0073385 5.0073385 -1.0783597 -1.1583617 -1.4470736 -1.8235397 -5.0073385 0.7490418 0.3768977 0.060588807 4.619997E-5 1.5349996E-4 150.0 400.0 Ckap2l_30216 70466 ckap2l 5 29 6.756202461387549 2.755372408809187E-4 0.021166269867670572 1.9557474 1.9557474 1.3603679 1.5435375 1.9557474 1.6577176 1.3234262 0.034356676 0.0015281502 0.008730677 0.0023381927 0.04767876 Rad51_31623 19361 rad51 5 29 12.416592082206025 1.7173034901896145E-6 4.837071497367414E-4 1.9498307 1.9498307 1.3106861 1.597658 1.9498307 1.4860888 1.5301173 0.038771026 3.1826357E-7 4.108024E-5 0.024239253 0.0060541118 Hlf_30768 217082 hlf 5 29 7.64168443215168 1.1036453690838055E-4 0.011657254210947696 3.0036716 3.0036716 -1.1190772 -1.1717683 -1.0029987 1.0732282 3.0036716 0.5553345 0.556014 0.9919575 0.64044964 4.23739E-6 150.0 400.0 Cks1b_31964 624855 cks1brt 5 29 6.402353598190457 4.0336590887735113E-4 0.02921521654297386 1.4636751 1.4636751 1.1624874 1.3385717 1.4636751 1.1979876 1.4404278 0.13352795 3.2668022E-4 0.0012742329 0.029310618 0.015690053 Gsta2_31572 14858 gsta2 5 29 10.459700009261676 8.248964103785283E-6 0.0014936517145068353 2.0557609 2.0557609 1.2937261 1.4048804 1.5506351 1.5084256 2.0557609 0.022918383 0.005888507 6.954861E-5 0.020958306 2.58047E-4 150.0 400.0 Pbk_30842 52033 pbk 5 29 8.859768829319183 3.405137192413754E-5 0.004647019243964455 2.245091 2.245091 1.4484472 1.6106191 2.245091 1.6387062 1.3507802 0.024168836 0.002252666 4.4825214E-5 0.0019834314 0.035344668 10.0 50.0 Hmgcs2_29615 15360 hmgcs2 5 29 8.681945457611974 4.020496542433971E-5 0.004853313683366722 -1.9133992 1.9133992 1.1124433 -1.046333 -1.0831102 -1.1771349 -1.9133992 0.385445 0.48704192 0.55328393 0.2503193 0.0031958795 Ces1g_30475 12623 ces1g 5 29 32.9037317199532 4.178901669149582E-11 1.059351573129419E-7 3.7703822 3.7703822 1.8519841 2.5884457 3.302021 3.4776027 3.7703822 2.0216223E-4 1.416067E-6 2.6020822E-7 6.85275E-6 3.6869867E-5 1.0 10.0 Kif20a_31171 52563 cdc23 5 29 8.76619118106406 3.715367688095217E-5 0.004709228544660687 1.8388748 1.8388748 1.3405029 1.6643624 1.8388748 1.5239298 1.0901855 0.12323248 0.0016786926 3.3502292E-4 4.622349E-4 0.3724363 Gm3776_29765 14857 gsta1 5 29 13.528464863611516 7.541291537904726E-7 2.627384210011213E-4 2.2273088 2.2273088 1.342727 1.2220078 1.7008519 1.5077457 2.2273088 0.015538143 0.062145703 5.987654E-6 0.018745732 6.8103673E-4 150.0 400.0 Hmmr_30734 15366 hmmr 5 29 5.897141613048253 7.065124791652E-4 0.041651375225204235 1.8891606 1.8891606 1.344725 1.547372 1.8891606 1.4488647 1.2889305 0.0811454 1.4986302E-4 0.0012274538 0.06726323 0.02104057 Rad54b_30165 623474 rad54b 5 29 7.022403421540873 2.0809057145410037E-4 0.018839628522719445 1.6678222 1.6678222 1.4626825 1.6678222 1.606202 1.4966274 1.4757149 0.04310584 1.9006506E-5 0.0041712113 0.0036694615 5.0289143E-4 Ect2_31257 13605 ect2 5 29 11.04125177135918 5.084586937931235E-6 9.914944528965908E-4 1.7929322 1.7929322 1.212423 1.3945026 1.7929322 1.5217974 1.051241 0.0126109 0.0034366744 0.0018556488 0.005034463 0.64204425 Dtl_29371 76843 dtl 5 29 15.783726315342706 1.6161640659095866E-7 8.595070803119054E-5 2.6029103 2.6029103 1.4652323 1.8276854 2.6029103 2.0416312 1.8129212 0.018478693 1.08540924E-4 1.6268543E-5 7.972973E-4 0.0017517031 10.0 50.0