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TR-296: Tetrakis(hydroxymethyl)phosphonium chloride (124-64-1), Tetrakis(hydroxymethyl)phosphonium sulfate (55566-30-8)

Study Results

Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
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  • No Evidence, Male, Rats
View
  • No Evidence, Male, Rats
View
  • No Evidence, Female, Rats
View
  • No Evidence, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • No Evidence, Male, Mice
View
  • No Evidence, Male, Mice
View
  • No Evidence, Female, Mice
View
  • No Evidence, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to TR-296: Tetrakis(hydroxymethyl)phosphonium chloride (124-64-1), Tetrakis(hydroxymethyl)phosphonium sulfate (55566-30-8).
Mammalian Cell Mutagenicity
View
  • Positive
View
  • Positive
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to TR-296: Tetrakis(hydroxymethyl)phosphonium chloride (124-64-1), Tetrakis(hydroxymethyl)phosphonium sulfate (55566-30-8).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to TR-296: Tetrakis(hydroxymethyl)phosphonium chloride (124-64-1), Tetrakis(hydroxymethyl)phosphonium sulfate (55566-30-8).
Bacterial Mutagenicity
View
  • Negative
View
  • Negative

Citation Information

NTP. TR-296: Tetrakis(hydroxymethyl)phosphonium chloride (124-64-1), Tetrakis(hydroxymethyl)phosphonium sulfate (55566-30-8). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TR-296 Toxicology and Carcinogenesis Studies of Tetrakis(hydroxymethyl)phosphonium sulfate (THPS) (CASRN 55566-30-8) and Tetrakis(hydroxymethyl)phosphonium chloride (THPC) (CASRN 124-64-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Study Data

Protocol

Toxicity and Carcinogenicity Studies

Evaluation of the Chronic Toxicity and Carcinogenicity of Tetrakis(hydroxymethyl)phosphonium Chloride (124-64-1) in Male F344 Rats Exposed via Gavage
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Tetrakis(hydroxymethyl)phosphonium Sulfate (55566-30-8) in Male F344 Rats Exposed via Gavage
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Tetrakis(hydroxymethyl)phosphonium Chloride (124-64-1) in Female F344 Rats Exposed via Gavage
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Tetrakis(hydroxymethyl)phosphonium Sulfate (55566-30-8) in Female F344 Rats Exposed via Gavage
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Tetrakis(hydroxymethyl)phosphonium Chloride (124-64-1) in Male B6C3F1 Mice Exposed via Gavage
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Tetrakis(hydroxymethyl)phosphonium Sulfate (55566-30-8) in Male B6C3F1 Mice Exposed via Gavage
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Tetrakis(hydroxymethyl)phosphonium Chloride (124-64-1) in Female B6C3F1 Mice Exposed via Gavage
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Tetrakis(hydroxymethyl)phosphonium Sulfate (55566-30-8) in Female B6C3F1 Mice Exposed via Gavage
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of Tetrakis(hydroxymethyl)phosphonium Chloride in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 778372
Summary Data
Genetic Toxicity Evaluation of Tetrakis(hydroxymethyl)phosphonium Sulfate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 337557
Summary Data