Chronic PFAS Exposure Induces Chemotherapy Resistance by Promoting Mitochondria-Related Alterations in Ovarian Cancer Cells
Brittany P. Rickard, Lauren A. Sapienza Lundie, Marta Overchuk, Justin Tulino, Mateus Prates Mori, James P. McCord, Vesna A. Chappell, Carl D. Bortner, Victoria L. Bae-Jump, Janine H. Santos, Suzanne E. Fenton, Imran Rizvi
Publication DOI: https://doi.org/10.1016/j.envres.2025.122211
DOI: https://doi.org/10.22427/NTP-DATA-500-109-001-000-6
Study Data
Figure 1
Effects of ST PFAS exposure on H2O2 production
- Data for Manuscript ER Fig 1 (13 KB)
- Figure 1, S7 Raw (29 KB)
Figure 2
Effects of long-term PFAS on mitochondrial membrane potential and mitochondrial content
- Data for Manuscript ER Fig 2 (13 KB)
- Figure 2B, C (19 KB)
- Figure 2D, E (12 KB)
Figure 3
Effect of long-term PFAS exposure on MitoSOX™ mean fluorescence intensity in OVCAR-3 and Caov-3 cells.
- Data for Manuscript ER Fig 3 (13 KB)
- Figure 3 Raw (17 KB)
Figure 4
Effects of long-term PFAS exposure on bioenergetic parameters in OVCAR-3 cells.
- Figure 4B,C & 5B,C (215 KB)
- Figure 4D and 5D (103 KB)
- Figure 4E and 5E (82 KB)
- Seahorse BCA Norm Fig04 05raw1 (34 KB)
- Seahorse BCA Norm Fig04 05raw2 (35 KB)
- Seahorse Raw Data Fig04 05raw1 (5 MB)
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- Seahorse Raw Data Fig04 05raw6 (2 MB)
Figure 5
Effects of long-term PFAS mixtures exposure on bioenergetic parameters in OVCAR-3 cells.
- Figure 4B,C & 5B,C (215 KB)
- Figure 4D and 5D (103 KB)
- Figure 4E and 5E (82 KB)
Figure 6
Carboplatin and doxorubicin response following long-term PFAS exposure in OVCAR-3 cells
- Data for Manuscript ER Fig 6 (32 KB)
- Figure 6 Raw (44 KB)
Figure 7
Effects of long-term PFAS exposure on chemotherapy efficacy in OVCAR-3 cells
- Data for Manuscript ER Fig 7 (23 KB)
- Figure 7 Raw (40 KB)
Figure 8
Effects of antioxidant (MitoTempo) treatment on chemotherapy efficacy in long-term PFAS-exposed OVCAR-3 cells.
- 10.17.2024 LT PFAS Chemotherapy + MitoTEMPO (NIEHS) (63 KB)
- 10.21.2024 LT PFAS Chemotherapy + MitoTEMPO (NCSU) (37 KB)
- 10.24.2024 LT PFAS Chemotherapy + MitoTEMPO (NCSU) (37 KB)
- 11.07.2024 LT PFAS Chemotherapy + MitoTEMPO (NCSU) (35 KB)
- 11.21.2024 LT PFAS Carboplatin + MitoTEMPO (NIEHS) (38 KB)
- Data for Manuscript ER Fig 8 (27 KB)
Figure 9
Effects of chronic PFAS exposure on survival fraction, mitochondrial membrane potential, and mitochondrial content.
- Data for Manuscript ER Fig 9 (15 KB)
- Figure 9 Raw (18 KB)
- Figure 9G & S16 Raw (28 KB)
Figure 10
Effects of chronic PFAS exposure on survival fraction post-chemotherapy treatment.
- Data for Manuscript ER Fig 10 (18 KB)
- Figure 10 Raw (28 KB)
Supplemental Materials
Supplemental Materials
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- Supplemental Data ER Table S01 (15 KB)
- Supplemental Data ER Table S01raw (409 KB)
- Supplemental Data ER Table S02 S03 (11 KB)
